1. N. N. Blokhin Russian Cancer Research Center, Moscow, Russia
2. I. M. Sechenov First Moscow State Medical University, Moscow, Russia

Keywords: ovarian cancer, stomach metastasis, immunocytochemistry, immunohistochemistry

Abstract: Stomach metastases from different types of malignant tumors are extremely rare. Common sources of secondary gastric involvement are breast and lung cancer, neoplasms of unknown primary site, malignant melanoma (2). Ovarian carcinomas average 0,013-1,6% of all gastric metastases (1). Ulceration is one of the important features of metastatic stomach lesions (3). We herein present the case of ovarian carcinoma metastasis to the stomach 13 years after panhysterectomy. Secondary gastric involvement was diagnosed during esophagogastroduodenoscopy and biopsy of posterior gastric wall infiltrated mucosa. The result was additionally confirmed immunohistochemically while analyzing biopsy specimens of visceral peritoneum. In conclusion, although gastric metastases from ovarian carcinoma is exceptionally rare, clinicians should nevertheless be aware that in patient with gastric tumor and a history of ovarian cancer, gastric lesions may be metastases from the ovarian cancer.

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Full text is published :
Bogush E. A., Malikhova O. A., Belyaeva T. V., Kirsanov V. Yu., Polikarpova S. B., Vysotskaya I. V., Ponomarev V. E. Metastatic lesion of the stomach in advanced ovarian cancer (case report). Experimental and Clinical Gastroenterology. 2019;163(3): 113–115. (In Russ.) DOI: 10.31146/1682-8658-ecg-163-3-113-115.
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1. The Loginov Moscow Clinical Scientific Center is State Institution funded by Moscow Health Department (The Loginov MCSC MHD) (Moscow, Russia)

Keywords: hepatocerebral dystrophy (Wilson-Konovalov disease), disorders of copper metabolism, ceruloplasmin, hepatic form, abdominal form, neurological disorders, diagnosis, D-penicillamine, zincteral, liver transplantation

Abstract: Wilson-Konovalov disease (WKD) is one of the most difficult to diagnose liver disease due to the long latent course in the early stages and the large polymorphism of symptoms in the advanced stage of the disease. The main signs of WKD are liver diseases, neuropsychiatric disorders, Kayser-Fleischer ring, acute episodes of hemolysis, often in combination with acute liver failure. The diagnosis is especially difficult in children and adults with active forms of liver disease. Timely diagnosis is an important medical and social problem, since early pathogenetic therapy improves the quality of life and social adaptation of patients. The article deals with the pathogenesis of BVK, the clinical and morphological features of the variants of the course of the disease: fulminant hepatic failure, chronic hepatitis and latent variant with the development of liver cirrhosis. An abdominal form with early development of edema and ascitic syndrome on the background of a violation of the synthetic function of the liver was identified. A detailed description of the role of a violation of copper metabolism To overcome the diagnostic problem, several clinical and laboratory signs are evaluated, as well as genetic testing in a point system; this assessment allows you to calculate the likely and very likely diagnosis. The tactics of drug therapy and the possibility of optimizing it are considered, the advantage of liver transplantation is evaluated. Two clinical observations of Wilson-Konovalov’s disease are presented, demonstrating the capabilities of various diagnostic methods (1st observation) and features of the course of the hepatic form of the disease (2nd observation).

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Full text is published :
Podymova S. D., Vinnitskaia E. V. Liver and hepatocerebral dystrophy. Experimental and Clinical Gastroenterology. 2019;163(3): 116–124. (In Russ.) DOI: 10.31146/1682-8658-ecg-163-3-116-124.
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