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Category: № 12 (148) 2017 y
    1. Military Medical Academy (Saint Petersburg, Russian Federation)

    Keywords: a chronic gastritis, H.pylori, the morphogenesis, recombinations, the new concept

    Abstract: In article logic contradictions of the developed representations about the nature of a chronic gastritis, modern difficulties and errors of its diagnostics are discussed, attempt becomes is critical to estimate a real role of infection H.pylori. On the basis of own long-term clinical and morphological experience the author results a number of the arguments testifying about multifactorial of damage of a mucous membrane of a stomach, but, during too time, about universality of the most basic sides of morphogenesis this pathology. Instead of the cascade theory assuming sequence of stages of morphogenesis, it is offered new (hierarchical, combinational) the concept of formation of a chronic gastritis, including as precancer condition.

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    Golofeevskii V.Yu. Reflections about the nature and general pattern of morphogenesis a chronic gastritis. Experimental and Clinical Gastroenterology Journal. 2017;148(12):76-81
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    1. Institute of Poliomyelites & viral Encephalitides (Moscow, Russian Federation)

    Keywords: Helicobacter pylori, eradication, chronic gastritis, peptic ulcer disease

    Abstract: A detailed critical analysis of the “Treatment of H. pylori infection” from all Maastricht agreements is presented in the dynamics of their improvement since 1996. It is shown that no significant changes occurred in these recommendations in either drugs used for eradication therapy, either in regimens treatment or in its results during the 20-year period. It is offered to refuse completely to use antibiotics that have been discredited (clarithromycin, metronidazole, etc.) in favor of using bactericidal preparations. It is necessary to radically review the procedure of treatment and switch from tablets to “liquid” technology, which allows acting directly on the infection throughout the surface of the gastric mucosa.

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    Full text is published :
    Morozov I.A. How to break the deadlock of Maastricht? Experimental and Clinical Gastroenterology Journal. 2017;148(12):82-88.
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    1. Sechenov First Moscow state medical university of the Russian federation Ministry of Health (Moscow, Russian Federation)
    2. Chuvash State University named after I.N. Ulyanov (Cheboksary, Russian Federation )

    Keywords: gastric ulcer, duodenal ulcer, neurogenic, genetic factors, neurosis, Helicobacter pylori

    Abstract: Purpose of the study . To develop the theory of the etiology of the author of the pathogenesis of peptic ulcer disease. Materials and Methods: In order to develop the author’s views on the etiology and pathogenesis of peptic ulcer treated with about 50 different publications and analyzed the results of their own research. Results. Therefore, genetic theory of neurogenic etiology and pathogenesis of gastric ulcer and duodenal ulcer 12 highly optimized explain causal relationships ulcer patient, allowing variations in the prevalence or otherwise of neurosis factor or local genetic factors. However, obviously other things that only a combination of neurogenic factor genetically altered reactivity of the gastroduodenal system (the presence of the target organ) causes chronic ulcers. Developed-tannaya our theory of peptic ulcer disease, a disease related to psychosomatic pathology allows to develop effective therapies including drugs with psihokorregiruyuschim action.

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    Full text is published :
    Kolotilova M.L., Ivanov L.N. Neurogenic-Genetic Factor Of Etiology And Pathogenesis Of Ulcer Disease. Experimental and Clinical Gastroenterology Journal. 2017;148(12):89-97
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