1. Smolensk State Medical University (Smolensk, Russian Federation)

Keywords: Helicobacter pylori, antimicrobial resistance, clarithromycin, metronidazole

Abstract: The article reviews current approaches to the choice of H. pylori eradication therapy depending on the antimicrobial susceptibility patters of this pathogen to the major components of eradication treatment. First and second line eradication therapy in patients with intolerance to antimicrobials are also discussed, as well as the options for the third line therapy in case of unknown H. pylori susceptibility patterns.

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Full text is published :
Dekhnich N.N., Ivanchik N.V., Prischepova E.A., Kozlov R.S. THE CHOOSE HELICOBACTER PYLORIERADICATION THERAPY IN ADULTS. Experimental and Clinical Gastroenterology Journal. 2017;148(12):60-66.
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1. North-Western State Medical University n. a. I. I. Mechnikov

Keywords: candidiasis, therapy of H. pylori proton pump inhibitors

Abstract: Pathogenesis of candidiasis of the digestive tract is characterized by sequential passage of the mushrooms following stages - adhesion, invasion, candidemia and visceral lesions. In the first stage, the micromycetes adhere to the epithelial cells of any portion of the mucous membrane. Further, defects in the system of resistance allows the micromycetes through transformation in pseudomycelia implemented (to invazirujutsja) in the mucous membrane and underlying tissues. Cytopenia - a crucial factor that allows invazirujutsja mushrooms to reach the walls of blood vessels, to destroy it, and to circulate in the bloodstream (this step is called candidemia). In the absence of adequate therapy in candidemia leads to the formation of foci of invasive candidiasis in visceral organs, most often in the liver and the spleen, the lungs, the Central nervous system. Introduction fungi of the genus Candida commonly occurs in areas of the mucous membrane, presents a multilayered epithelium (mouth, esophagus) and significantly less in single-layer epithelium (stomach, intestines). Proton pump inhibitors, reducing the acidity of the upper gastrointestinal tract and antibiotics killing the natural competitors of micromycetes of bacteria that can cause candidiasis, especially in patients at risk. The data on etiology, clinical features, diagnostic criteria and treatment of the most common oral lesions..

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Full text is published :
Shevyakov M.A. Melekhina Yu.E., Klimko N.N. CANDIDIASIS OF MUCOUS MEMBRANES AS A COMPLICATION OF THE COURSE OF HELICOBACTER-ERADICATION. Experimental and Clinical Gastroenterology Journal. 2017;148(12):67-71.
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1. Clinic № 1 of Department for presidential Affairs of RF

Keywords: Helicobacter pylori,gastro,schemes of eradication,H. pylori therapy,food allergies,intolerance of antibiotics,antibiotic resistance

Abstract: The study of the pathogenic properties of Helicobacter pylori have shown that this microorganism is able to damage the mucous membrane of the stomach and duodenum may contribute to the protracted course of gastroduodenitis, increases the frequency of relapses. This has changed approaches to the treatment and especially the prevention of recurrence. Developed and widely used in eradication schemes with the prolonged use of multiple antibiotics, which often leads to serious complications. In this article, we analyzed a number of controversial issues related to the study of HP-associated pathology.

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Full text is published :
Drynov G.A.,Ivaniushina D.C.,Mikhalina I.A., THE ROLE OF Helicobacter pylori INFESTATION IN ALLERGIC PATHOLOGY: DISCUSSION QUESTIONS. Experimental and Clinical Gastroenterology Journal. 2017;148(12):72-75.
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