1. Centre for Strategic Planning and Management of Biomedical Health Risks, 119992, Moscow, Russia
2. L. M. Sechenov First Moscow State Medical University, 119991, Moscow, Russia

Keywords: infl ammation bowel disease, aetiopathogenesis, commensal gut microbiota, Akkermansia muciniphila, dysfunction of local immune responses, intestinal infl ammation, probiotics, metabiotics, FMT, clinical application in IBD

Abstract:Infl ammatory bowel disease (IBD) has increasing socio-medical and economic signifi cance for humans. Although the aetiopathogenesis of IBD is not fully established, it is believed that the imbalance of intestinal microbiota of the gastrointestinal tract and modifi cation of the intestinal immune system are the most important triggering mechanisms of risk, development and progression of IBD, their relapses and activation. Epidemiological, microbiological and immunological studies have identifi ed some pathogenic and commensal intestinal bacteria that can induce disturbances of local immune responses and predispose the risk of IBD. The review deals with the mechanism of participation of commensal intestinal anaerobic gram-negative Akkermansia muciniphila in the destruction and metabolism of the intestinal mucosa and modulation of epigenetic mechanisms, physiological, metabolic, immune and signal functions associated with the development of IBD. The use and limitations of these living bacterial commensals and their low molecular weight components and metabolites in the prevention and treatment of IBD are discussed. Challenges, limitations and potential improvement strategies using some commensal anaerobic bacteria and fecal microbiota transplantation in IBD are also considered.

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Full text is published :
Shenderov B. A., Yudin S. M., Zagaynova A. V., Shevyreva M. P. The role of commensal gut bacteria in the aetiopathogenesis of infl ammatory bowel disease: Akkermansia muciniphila. Experimental and Clinical Gastroenterology. 2018;159(11): 4–13. (In Russ.) DOI: 10.31146/1682-8658-ecg-159-11-4-13
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