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    1. Moscow clinical scientific practical center of the Department of health of Moscow (Moscow, Russian Federation)
    2. Research Institute for health organization and medical management of the Department of health of Moscow (Moscow, Russian Federation)
    3. State budgetary educational institution of higher professional education “North-Western state medical University n. a. I. I. Mechnikov” (St. Petersburg, Russian Federation)

    Keywords:Inflammatory bowel disease,epidemiology,incidence

    Abstract:Prevalence and incidence of inflammatory bowel disease (IBD) is significantly inferior to other diseases of the digestive system, but in severity, frequency of complications and mortality in the world they occupy one of the leading positions in the structure of diseases of the gastrointestinal tract. The results of the large controlled studies show a steady increase in the incidence of this disease in the world. According to recent reports the prevalence of ulcerative colitis (UC) in North America is 249 per 100 thousand population, Crohn’s disease (CD) - 319 to 100 thousand, the prevalence of UC in Europe is 505 per 100 thousand population, CD - 322 to 100 thousand; the incidence of UC in North America is 19.2 per 100 thousand population, CD - 20.2 per 100 thousand, UC incidence in Europe is 24.3 per 100 thousand population, CD - 12.7 per 100 thousand. However, there are no clear data on the prevalence and incidence of this pathology in our country. This circumstance requires the creation of a unified register of patients with UC and CD, which will contribute to the improvement of the measures of care for patients with IBD.

      1. Cecil W. Ward and Derek T. Thomas. Crohn’s Disease with Acute Obstruction, Br Med J. 1941 Nov 1; 2(4217): 613-614.
      2. Crohn BB. Inflammatory diseases of the small intestine. J Omaha Midwest Clin Soc. 1946 Aug;7(3):77-83.
      3. Molodecky NA, Soon IS, Rabi DM, et al. Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology. 2012;142(1):46-54. e42; quiz e30.
      4. Kappelman MD, Rifas-Shiman SL, Kleinman K, Ollendorf D, Bousvaros A, Grand RJ, Finkelstein JA. The prevalence and geographic distribution of Crohn’s disease and ulcerative colitis in the United States. Clin Gastroenterol Hepatol. 2007; 5:1424-9.
      5. Loftus EV., Jr The burden of inflammatory bowel disease in the United States: a moving target? Clin Gastroenterol Hepatol. 2007;5:1383-4.
      6. Muller-Lissner S.A., Bollani S., Brummer R. J. et al. Epidemiological aspects of irritable bowel syndrome in Europe and North America // Digestion. -2001. - Vol. 64, № 3. - P. 200-204.
      7. Schultes H., Guminski W., Rosche U. et al. Irritable bowel syndrome costs sickness funds DM 2.8 billion per year // Value in Health. - 2001. - Vol. 4, Sep-Oct, Issue 2. - P. 123.
      8. Воробьев П. А., Воробьев П. А., Авксентьева М. В., Юрьев А. С., Сура М. В. Клинико-экономический анализ (оценка, выбор медицинских технологий и управление качеством медицинской помощи) (Под ред. Воробьева П. А.) - М.: «Ньюдиамед», 2004. - 404 с.
      9. Lesage S., Zouali H., Colombel J.-F. et al. Genetic analyses of chromosome 12 loci in Crohn’s disease. // Gut. - 2000. - 47. - p. 787-791.
      10. Satsangi J. Genetics of inflammatory bowel disease. // Falk Symp. № 85. -1995. - p.50.
      11. Е. Ю. Валуйских, И.О, Светлова, С. А. Курилович, М. Ф. Осипенко, В. Н. Максимов, М. И. Воевода. Клинико-генетические аспекты воспалительных заболеваний кишечника. Российский журнал гастроэнтерологии, гепатологии и колопроктологии. - 2008. - Т. 18. - № 6. - С. 68-74.
      12. Никулина И. В. Златкина А. Р., Белоусова Е. А., Румянцев В. Г., Юрков М. Ю. Оценка клинико-эпидемиологических показателей воспалительных заболеваний кишечника в Московской области // Российский журнал гастроэнтерологии, гепатологии, колопроктологии.-1997.-, № 2. - с. 67-71.
      13. Николаева Н. Н., Чечеткина И. Д., Николаева Л. В., Гигилева Н. Л. Эпидемиология язвенного колита и болезни Крона в Красноярском крае // Российский журнал гастроэнтерологии, гепатологии, колопроктологии. - 2004.-14. - № 5. - с. 133; 496.
      14. Irvine EJ, Farrokhyar F., Swarbrick E. T. A critical review of epidemiological studies in inflammatory bowel disease. Scand, Scand.J.Gastroenterol.2001.36[1]:2-15.
      15. Cachia E, Calleja N, Aakeroy R, Degaetano J, Vassallo M. Incidence of inflammatory bowel disease in Malta between 1993 and 2005: a retrospective study. Inflamm Bowel Dis. 2008 Apr;14(4):550-3.
      16. Mendelof A. I. The epidemiolody of chronic inflammatory bowel disease // Inflammatory Bowel Disease. Ed. by G. Jarnerot.-1992. - p.15-34.
      17. Langholz E. Epidemiology of IBD and colorectal cancer in IBD. // International meeting “Prevention of colorectal cancer with 5-ASA. - Copenhagen, May 2000.
      18. Söderlund S, Granath F, Broström O, Karlén P, Löfberg R, Ekbom A, Askling J. Inflammatory bowel disease confers a lower risk of colorectal cancer to females than to males. Gastroenterology. 2010 May;138(5):1697-703.
      19. Binder V. Epidemiology // Inflammatory Bowel Disease-from bench to bedside. Ed. Andus T. et al. Proceeding of Falk-symposiun № 96.-1996.-Kluwer Academic Publishers.
      20. Munkholm P., Langholz E., Nielsen J, H, et al. Incidence and prevalence of Crohn’s disease in the county of Copenhagen, 1962-87: a sixfold increase in incedence. Scand.J.Gastroenterol.1992, B 7):609-614.
      21. Binder V., Both H., Hansen P. K. et al. Incidence and prevalence of ulcerative colitis and Crohn’s disease in the County of Copenhagen, 1962-1978. Gastroenterology, 1982,83C):563-568.
      22. Shivanada S., Lennard-Jones J., Logan R. Incidence of inflammatory bowel disease across Europe: is there a difference between north and south? Results of the European Collaborative Study of the Inflammatory Bowel Disease EC-IBD).-Gut.-1996.-39 E).-690-697.
      23. Fonager K., Sorensen H. T., Olsen J. Change in incidence of Crohn’s disease and ulcerative colitis in Denmark. A study based on National Registry of Patients, 1981-1992. Int J. Epidemiol.-1997.;26;1003-1008.
      24. Trallori G., Palli D., Saieva С et al. A population-based study of inflammatory disease in Florence over 15 years A978-92). Scand.J, Gastroenterol.1996;31(9):892-899.
      25. Ekbom A., Helmick C, Zack M., Adami H-O. The epidemiolody of inflammatory bowel disease: a large population-based study in Sweden // Gastroenterology. - 1991. - v. 100. - p. 350-358.
      26. Zvidi I, Hazazi R, Birkenfeld S, Niv Y. The prevalence of Crohn’s disease in Israel: a 20-year survey. Dig Dis Sci. 2009 Apr;54(4):848-52.
      27. Haug A., Schrumpf E., Barsted S., Fluge. Et al. Epidemiolody of ulcerative colitis in Western Norway// Scand. J. Gastroenterol.-1988. - 23. - p.517-522.
      28. Kildebo S., Nordgard K., Aronsen O., Brecken P. et al. The incidence of ulcerative colitis in Northern Norway from 1983 to 1986. // Scand. J. Gastroenterol.-1990. - v.25. - p.890-896.
      29. Myren J., Gjone E., Hertzberg J. Epidemiolody of ulcerative colitis and regional enterocolitis (Crohn’s disease) in Norway//Scand. J. Gastroenterol.-1971. - v.6. - p.511-514.
      30. Vatn M., Mourn В., the IBSEN study group. IBD in Norway // Inflammatory Bowel Disease. Ed. Monteiro E., Taravela F. Proceedings of Falk-symposiun № 76.-1994.-Kluwer Academic Publishers.
      31. Mourn B., Vatn M. H. Ekbom A. et al. Incidence of inflammatory bowel disease in southeastern Norvay: evaluation of methods after 1 year of registration. Southeastern Norvay IBD Study Group of Gastroenterologists. Digestion 1995,56E):377-381.
      32. Bianchi P., Bodini P., Zambelli A., Curzio M., Ranzi T. Epidemiolody of IBD in Italy//Inflammatory Bowel Disease. Ed. Monteiro E., Taravela F. Proceedings of Falk-symposiun № 76.-1994.-Kluwer Academic Publishers.
      33. Sonnenberg A., McCarty D.J., Jacobsen S. J. Geographic variation of inflammatory bowel disease within the United States. Gastroenterology 1991, 100[1]: 143-149.
      34. Mayberry J. F., Mann R. Inflammatory bowel disease in rural sub-Saharan Africa: rarity of diagnosis in patients attending mission hospitals. Digestion 1989; 44C):172-176.
      35. Yang S. K., Loftus E. V. Jr, Sandbom W. J. Epidemiology of inflammatory bowel disease in Asia. Inflamm.Bowel Dis. 2001, 7C);260-270.
      36. Yoshida Y., Murata Y. Inflammatory Bowel Disease in Japan: studies of epidemiology and etiopathogenesis // Med Clin North Am.-1990.-V. 74. - p. 67-89.
      37. Burisch J., Pedersen N., Сukoviс-Сavka S., et al. East-West gradient in the incidence of inflammatory bowel disease in Europe: the ECCO-EpiCom inception cohort. Gut.2014;63(4):588-97.
      38. Braegger CP, Ballabeni P, Rogler D, Vavricka SR, Friedt M, Pittet V. Epidemiology of inflammatory bowel disease: is there a shift towards onset at a younger age? Swiss IBD Cohort Study Group.J Pediatr Gastroenterol Nutr. 2011 Aug;53(2):141-4.
      39. Bernstein C.N, Blanchard J. F., Rawsthorne P., Wajda A. Epidemiology of Crohn’s disease and ulcerative colitis in the central Canadian province: a population-based studi. Am J Epidemiol 1999,149A0):916-924.
      40. Farrokhyar F., Swarbrick E., Grace R. et al. Low mortality in ulcerative colitis and Crohn’s disease in three regional centers in England. Am J. Gastroenterol.;96B):501-507.
      41. Colombel J., Salomaz J., Cortot A. Incidence of inflammatory bowel disease in Northwestern France. Preliminary results in redion Pas-de-Calais // Scand. J. Gastroenterol.-1989. - 24.-(Suppl.170).-p.22-24.
      42. Tysk CJarnerot G. Ulcerative proktocolitis in Orebro, Sweden- a retrospektive epidemiologic study, 1963-87. Scand.J.Gastroenterol. 1992;27:945-950.
      43. Mendelof A. I. The epidemiolody of chronic inflammatory bowel disease // Inflammatory Bowel Disease. Ed. by G. Jarnerot.-1992. - p.15-34.
      44. Veluswamy H, Suryawala K, Sheth A, Wells S, Salvatierra E, Cromer W, Chaitanya GV, Painter A, Patel M, Manas K, Zwank E, Boktor M, Baig K, Datti B, Mathis MJ, Minagar A, Jordan PA, Alexander JS. African-American inflammatory bowel disease in a Southern U. S. health center. BMC Gastroenterol. 2010 Sep 9;10:104.
      45. Bernstein C. N., Kraut A., Blanchard J. F. et al. The relationship between inflammatory bowel disease and socioeconomic variables. Am J. Gastroenterol.2001;96G):2117-2125.
      46. Loftus E., Silverstein M., Sandbom al. Ulcerative colitis in Olmsted County, Minnesota, 1940-1993; incidence, prevalence, and survival. Gut 2000,46C):336-343.
      47. Berner J., Kiaer Т. Ulcerative colitis and Crohn’s disease on the Faroe Islands 1964-83. A retrospective epidimiological survey. -Scand. J. Gastroenterol. - 1986. - 21.-188-192.
      48. Siddique I, Alazmi W, Al-Ali J, Al-Fadli A, Alateeqi N, Memon A, Hasan F. Clinical epidemiology of Crohn’s disease in Arabs based on the Montreal classification. Inflamm Bowel Dis. 2011 Oct 10. doi: 10.1002/ibd.21890.
      49. Malaty HM, Hou JK, Thirumurthi S. Epidemiology of inflammatory bowel disease among an indigent multi-ethnic population in the United States. Clin Exp Gastroenterol. 2010;3:165-70.
      50. Fireman Z., Grossman A., Lilos P. Epidemiology Crohn’s disease in the Jewish population of Central Israil.//Am J Gastroenterol.-1989.-v.84.-p.255-258.
      51. Odes H., Fraser D., Krawuec J. Incidence of idiopathic ulcerative colitis in Jewish population subdroup in the Beer Sheva region of Israil.// Am J Gastroenterol.-1987. - v.82.-p.854-858.
      52. Левитан М. Х., Смесова Р. Неспецифический язвенный колит и беременность // Врачебное дело, 1981. - № 3. - С. 29-32.
      53. Allan, RN et al. Inflammatory Bowel Disease. London: Churchill Livingstone, 1997.
      54. Höie O, Wolters F, Riis L, Aamodt G, Solberg C, Bernklev T, Odes S, Mouzas IA, Beltrami M, Langholz E, Stockbrügger R, Vatn M, Moum B; European Collaborative Study Group of Inflammatory Bowel Disease (EC-IBD). Ulcerative colitis: patient characteristics may predict 10-yr disease recurrence in a European-wide population-based cohort. Am J Gastroenterol. 2007 Aug;102(8):1692-701.
      55. Sonnenberg A, Walker JT. Occupational mortality associated with inflammatory bowel disease in the united states 1984-1998. Inflamm Bowel Dis. 2011 Jun 24. doi: 10.1002/ibd.21807.
      56. Kennedy NA, Clark DN, Bauer J, Crowe AM, Knight AD, Nicholls RJ, Satsangi J. Nationwide linkage analysis in Scotland to assess mortality following hospital admission for Crohn’s disease: 1998-2000.Aliment Pharmacol Ther. 2011 Nov 9. doi: 10.1111/j.1365-2036.2011.04906.x.
      57. Brostrom O., Monsen U., Nordenwall B. et al. Prognosis and mortality of ulcerative colitis in Stockholm County, 1955-1979. Scand.J.Gastroenterol. 1987;22(8):907-91.
      58. Ekbom A., Helmick C. G., Zack M. et al. Survival and causes of death in patients with inflammatory bowel disease; a population-based study. Gastroenterology, 1992;103C):954-960.
      59. Probert C. S., Jayanthi V., Wicks A. C., Mayberry J. F. Mortality in patients with ulcerative colitis in Leicestershire, 1972-1989. An epidemiological study. Dig.Dis, Sci, 1993;38{3}:538-541.
      60. Romberg-Camps M, Kuiper E, Schouten L, Kester A, Hesselink-van de Kruijs M, Limonard C, Bos R, Goedhard J, Hameeteman W, Wolters F, Russel M, Stockbrügger R, Dagnelie P. Mortality in inflammatory bowel disease in the Netherlands 1991-2002: results of a population-based study: the IBD South-Limburg cohort. Inflamm Bowel Dis. 2010 Aug;16(8):1397-410.

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    Knyazev O.V., Shkurko T.V., Fadeeva N.A., Bakulin I.G. et. al EPIDEMIOLOGY OF CHRONIC INFLAMMATORY BOWEL DISEASE. YESTERDAY, TODAY, TOMORROW. Experimental and Clinical Gastroenterology Journal. 2017;139(03):04-12
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