1. The medical simulation center of the Botkin clinical hospital (Moscow, Russian Federation)

Keywords:simulation technology,medical profession,engineering education process,the tools of lean manufacturing,elimination of waste

Abstract:This article discusses the current results of the organization and management of educational activities of the modern training center medical simulation center, Botkin hospital, using the tools of “lean management” with the latest implementation of the training process.

• References total 43 ⇓ :: .
  1. Медведев Д. А. Социально-экономическое развитие России: обретение новой динамики// Вопросы экономики. - 2016. - № 10. - С. 28. [Электронный ресурс]. Режим доступа: www.vopreco.ru/rus/redaction.files/10-16.pdf. (дата обращения: 05.12.2016).
  2. Декларация по медицинскому образованию. 39 Всемирная Медицинская Ассамблея, Мадрид, Испания, октябрь 1987 [Электронный ресурс]. Режим доступа: www.med-pravo.ru/International/Educ_Decl.htm (дата обращения: 01.02.2017).
  3. Приказ Министерства здравоохранения Российской Федерации № 422ан от 07.07.2015 г. «Об утверждении критериев оценки качества медицинской помощи».
  4. Приказ Министерства здравоохранения Российской Федерации № 520н от 15.07.2016 г. «Об утверждении критериев оценки качества медицинской помощи».
  5. Кицул И. С., Пивень Д. В. Новые критерии оценки качества медицинской помощи: комментарий экспертов / Заместитель главного врача. - 2016. - № 11. [Электронный ресурс]. Режим доступа: www.e.zamglvracha.ru/article.aspx?aid=503322 (дата обращения: 21.01.2017).
  6. Старченко А. А. Критерии оценки качества медицинской помощи: важный шаг в направлении уважения прав пациентов, врачей и экспертов / Менеджер здравоохранения. - 2015. - № 9. [Электронный ресурс]. Режим доступа: www.cyberleninka.ru/article/n/kriterii-otsenki-kachestva-meditsinskoy-pomoschi-vazhnyy-shag-v-napravlenii-uvazheniya-prav-patsientov-vrachey-i-ekspertov. (дата обращения: 25.12.2016).
  7. Свистунов А. А. Перспективы развития симуляционного обучения в системе профессионального медицинского образования / А. А. Свистунов // I съезд Российского общества симуляционного обучения в медицине - 2012 (27-28 сентября 2012 г., Москва). - М., 2012. - С. 68.
  8. Мирошниченко И. В. Обучающий симуляционный центр как координатор создания и реализации сквозной программы практической подготовки специалистов в здравоохранении / И. В. Мирошниченко, Т.В Чернышева, Ю. А. Юдаева, Е. М. Нефедова // Современные тенденции развития педагогических технологий в медицинском образовании. Вузовская педагогика: материалы конф. / гл. ред. С. Ю. Никулина. - Красноярск: Тип. КрасГМУ, 2016. - С. 388-391.
  9. Cooper J. B., Taqueti V. R. A brief history of the development of mannequin simulators for clinical education and training / Postgrad Med J. - 2008. - № 84 (997). - Р. 563-570.; Pratt D. D. Five Perspectives on Teaching in Audit and Higher Education / Melbourne, FL Krieger Publishing Co. - 1998. - № 83. - Р. 103.
  10. Медведев Д. А. Социально-экономическое развитие России: обретение новой динамики/ Вопросы экономики. - 2016. - № 10. - С. 18, 22, 24. [Электронный ресурс].: www.vopreco.ru/rus/redaction.files/10-16.pdf. (дата обращения: 05.02.2017).
  11. Лившиц В. Век бережливого производства - Lean manufacturing. [Электронный ресурс]. Режим доступа: http://www.proza.ru/2007/03/25-282. (дата обращения: 11.02.2017).
  12. Валькович О. Н., Коротких Л. В. Совершенствование системы управления персоналом на российских предприятиях: особенности применения зарубежных моделей // Электронный научно-практический журнал «Экономика и менеджмент инновационных технологий». - 2015. - № 12.
  13. Царенко А. С. Бережливое государство: опыт и перспективы /Издательский дом «Бюджет». - 2016. - № 3 (март). [Электронный ресурс]. Режим доступа: www.bujet.ru/article/293109.php (дата обращения: 29.02.2017).
  14. Никулина О. В., Коноваленко Д. Г. Применение инновационных технологий бережливого производства в практике таксомоторных компаний: проблемы и пути их решения в инновационной сфере // Экономика и предпринимательство. - 2013. - № 7(36).
  15. Бурыкин И. М., Вафин А. Ю., Хафизьянова Р. Х. Повышение эффективности менеджмента учреждений здравоохранения в современных условиях на основе принципов бережливого производства / Фундаментальные исследования. - 2013. - № 7-3. - С. 523-529. [Электронный ресурс]. Режим доступа: www.fundamental-research.ru/ru/article/view?id=32048 (дата обращения: 01.02.2017).
  16. Бурнашева Э. П. Использование инструментов бережливого производства в проектировании образовательного процесса / Интеграция образования. - 2016. Т. 20. - № 1. - С. 105-111. [Электронный ресурс]. Режим доступа: www.edumag.mrsu.ru/content/pdf/16-1/11.pdf (дата обращения: 17.02.2017).
  17. Вэйдер М. Инструменты бережливого производства. - М.: Альпина Бизнес Букс, 2007. - 125 с.
  18. Лапидус В. А. Ведение бизнеса. Менеджмент качества - начнем сначала / Менеджмент качества (Казахстан). - 2010. - № 1. [Электронный ресурс]. Режим доступа: www.quality.eup.ru/MATERIALY 14/vb-mk.htm. (дата обращения: 15.02.2017).
  19. «Точно вовремя» для рабочих / Пер. с англ. - М.: Институт комплексных стратегических исследований, 2007. - 112 с.
  20. Баранская И. Кайдзен: 5 принципов, обеспечившие успех японской модели управления / Электронный ресурс. Режим доступа: https://lifehacker.ru/2013/01/27/kaizen/(дата обращения: 29.01.2017).
  21. Кононова В. Применение Lean Manufacturing на промышленных предприятиях России в 2006-2008 гг. / Официальный сайт Института комплексных стратегических исследований (ИКСИ). [Электронный ресурс]. Режим доступа: www.icss.ac.ru/userfiles/file/l.pdf (по состоянию на 08.05.2012).
  22. База данных «ProQuest». / [Электронный ресурс]. Режим доступа: www.proquest.co.uk/en-UK/ (дата обращения 28.02.2017).
  23. Разработка стратегии / [Электронный ресурс]. Режим доступа: www.leancor.ru/text/9459 (дата обращения: 09.02.2017).
  24. Баранов А., Чичелов Р. Бережливое производство: маленькие шаги для больших целей / Генеральный директор. - 2016. - 29 августа. [Электронный ресурс]. Режим доступа: www.gd.ru/articles/3578-berejlivoe-proizvodstvo (дата обращения: 17.02.2017).
  25. Womack, James P. and Daniel T. Jones. Lean Thinking: Banish Waste and Create Wealth in Your Corporation, Revised and Updated, Second Edition. -New York: Simon & Schuster, 2003. - 397 р.
  26. Бурыкин И. М., Хафизьянова Р. Х., Алеева Г. Н. Возможности использования подхода «бережливое производство» (Lean production) в медицине / Здоровье - основа человеческого потенциала: проблемы и пути их решения. - 2012. - № 2. - Том. 7. Электронный ресурс. Режим доступа: www.cyberleninka.ru/article/n/vozmozhnosti-ispolzovaniya-podhoda-berezhlivoe-proizvodstvo-lean-production-v-meditsine#ixzz4XQeLbnuX (дата обращения: 15.01.2017).
  27. Shazali N. A. Lean Healthcare Practice and Healthcare Performance in Malaysian Healthcare Industry // International Journal of Scientific and Research Publications. - 2013. - Vol. 3. - № 1. - Р. 1-5.
  28. Ершова И. В., Клюев А. В. Философия бережливого производства. «Компаньон», издание Торгово-промышленной палаты г. Набережные Челны и региона «Закамье», 2010.
  29. Сафонова К. О. Человеческий фактор в функционировании «думающего предприятия» («lean thinking»)/ Вестник УрФУ. Серия Экономика и управление. - 2014. - № 1. - С. 150-157. [Электронный ресурс]. Режим доступа: www.sovman.ru/article/2806/ (дата обращения: 21.02.2017).
  30. Матюхин, П.В. «Кайдзен» - ключевая стратегия японского менеджмента // Международный журнал прикладных и фундаментальных исследований. - 2009. - № 5. - С. 108.
  31. Метод «5 почему». / [Электронный ресурс]. Режим доступа: www.inventech.ru/pub/methods/metod-0002/ (дата обращения: 09.12.2016).
  32. Инструменты анализа / [Электронный ресурс]. Режим доступа: www.texnlit.ru/bereglivoe41.html (дата обращения: 09.07.2016).
  33. Картирование потока создания ценности / [Электронный ресурс]. Режим доступа: www.center-smk.ru/lean-manufacturing/leanway/ (дата обращения: 21.12.2016).
  34. Горшков М. Г. Вопросы классификации симуляционных центров / [Электронный ресурс]. Режим доступа: www.rosomed.ru/kniga/voprosi_klassifikatii_simulationnogo_obucheniya.pdf (дата обращения 10.12.2016).
  35. http://botkinmoscow.ru/simcenter/training-courses/
  36. Такеда Х. Синхронизированное производство. /Пер. с англ. - М.: Институт комплексных стратегических исследований, 2008. - 288 с.; Канбан и «точно вовремя» на Toyota: Менеджмент начинается на рабочем месте / Пер. с англ. - М.: АЛЬПИНА ПАБЛИШЕР, 2014. - 214 с.
  37. Глыбочко П. В. Образовательно-кадровый континуум в здравоохранении / П. В. Глыбочко / Медицинское образование и вузовская наука. - 2015. - № 1. - С. 6-9. [Электронный ресурс]. Режим доступа: www.movn.ru (дата обращения: 23.02.2017).
  38. Литвиненко С. Следующий шаг в НМО - персонификация / 2017. - 06.02. [Электронный ресурс]. Режим доступа: www.medvestnik.ru/content/interviews/Sleduushii-shag-v-NMO-personifikaciya.html (дата обращения: 15.02.2017). Интервью главного внештатного специалиста уролога Минздрава России и Департамента здравоохранения Москвы, научного руководителя Московской урологической школы Д. Ю. Пушкаря.
  39. Имаи М. Кайдзен: Ключ к успеху японских компаний / Пер. с англ. - М.: Альпина Паблишер, 2013. - 274 с.
  40. Вумек Дж. Бережливое производство: Как избавиться от потерь и добиться процветания вашей компании / Дж. Вумек, Д. Джонс; Пер. с англ. - М.: АЛЬПИНА ПАБЛИШЕР, 2014. - 472 с.
  41. Вумек Дж. Бережливое производство: Как избавиться от потерь и добиться процветания вашей компании / Дж. Вумек, Д. Джонс; Пер. с англ. - М.: АЛЬПИНА ПАБЛИШЕР, 2014. - 472 с.
  42. Палкин С. В. Система практических мер по внедрению бережливого производства. - М.: НП «ОПЖт», 2009.
  43. Бурнашева Э. П. Использование инструментов бережливого производства в проектировании образовательного процесса / Интеграция образования. - 2016. Т. 20. - № 1. - С. 106. [Электронный ресурс]. Режим доступа: www.edumag.mrsu.ru/content/pdf/16-1/11.pdf (дата обращения: 17.02.2017).

Full text is published :
Logvinov Yu.I. THE DESIGN OF THE EDUCATIONAL ACTIVITIES OF A MODERN SIMULATION CENTER BASED ON THE PRINCIPLES OF “LEAN MANAGEMENT”: CONCEPTUAL ASPECTS. Experimental and Clinical Gastroenterology Journal. 2017;140(04):04-14
Read & Download full text

1. The Federal State Budgetary Scientific Institution «Petrovsky National Research Center of Surgery» (Moscow, Russian Federation)

Keywords:dysplasia of epithelium,intestinal metaplasia,columnar-celled metaplasia,argon-plasma coagulation,endoscopic mucosal resection

Abstract:The aim of the study is the rationalizing of the strategy change of endoscopic diagnostics, follow-up and treatment of patients with Barrett’s esophagus. From 2007 to 2015 Barrett’s mucosa has been defined during upper endoscopy in 111 patients of the main group. Another 12 patients with Barrett’s esophagus were followed-up from 1995 to 2010-2015. Endoscopic argon-plasma coagulation of the abnormal areas of the Barrett’s mucosa was performed in 17, endoscopic mucosal resection in 2 patients. The result was the recovery of stratified squamous esophageal epithelium. The remaining 92 patients were treated only by drug therapy. None of the 111 patients in the main group and as well as 12 patients followed-up since 1995, had any progression of Barrett’s esophagus of any length metaplasia segment, nor on the expression of intestinal metaplasia or dysplasia. Extensive experience in endoscopic diagnostics of esophageal diseases and the use of high resolution and high definition endoscopes with a variety of additional features are the base of a correct diagnosis of Barrett’s esophagus.

• References total 8 ⇓ :: .
  1. Koppert L., Wijnhoven B., van Dekken H., Tilanus H., Dinjens W. The molecular biology of esophageal adenocarcinoma. J Surg Oncol (2005) 92 (3): 169-90. PMID 16299787.
  2. Levine D.S., Blount P. L., Rudolph R. E., et al. Safety of a systematic endoscopic biopsy protocol in patients with Barrett’s esophagus. Am J Gastroenterol 2000; 95: 1152-7
  3. Май Андреа. Эндоскопическая диагностика и лечение пищевода Барретта с неоплазией и без. Эндоскопия 4, 2012: 11-16.
  4. Aoki T., Kawaura Y., Kouzu T., et al. Report of the Research Committee on the Definition of Barrett’s Esophagus (Epithelium) [in Japanese]. In: Sugimachi K, editor. Reports of the research committees of The Japanese Society for Esophageal Diseases. Chiba: Japanese Society of Esophageal Diseases; 2000: 20-23.
  5. Choi do W., Oh S. N., Baek S. J. et al. Endoscopically observed lower esophageal capillary patterns. Korean J. Intern. Med. - 2002. - Vol. 17, N 4. - P. 245-248.
  6. Ивашкин В.Т., Маев И. В., Трухманов А. С. и др. Клинические рекомендации Российской Гастроэнтерологической Ассоциации по диагностике и лечению пищевода Барретта, 2014.
  7. Vahabzadeh B., Seetharam A. B., Cook M. B., et al. Validation of the Prague C & M criteria for the endoscopic grading of Barrett’s esophagus by gastroenterology trainees: a multicenter study. Gastrointest Endosc 2012; 75: 236-41.
  8. Yousef F., Cardwell C., Cantwell M. M., et al. The incidence of esophageal cancer and highgrade dysplasia in Barrett’s esophagus: a systematic review and meta-analysis. Am J Epidemiol 2008; 168: 237-249.

Full text is published :
Godzhello E.A., Khrustaleva M.V., Bulganina N.A., Shatveryan D.G. et al. MODERN STRATEGY OF BARRETT’S ESOPHAGUS ENDOSCOPIC DIAGNOSTICS, TREATMENT AND FOLLOW-UP. Experimental and Clinical Gastroenterology Journal. 2017;140(04):15-21
Read & Download full text

1. I. M. Sechenov First Moscow State Medical University (Moscow, Russian Federation)
2. Clinical Hospital № 15 named after O. M. Filatov (Moscow, Russian Federation)

Keywords:pancreatitis,acute interstitial pancreatitis,pancreatic necrosis,gastroduodenoscopy

Abstract:Aim: Endoscopic diagnosis of changes in the upper gastrointestinal tract in patients with acute pancreatitis and pancreatic necrosis. Materials and Methods: The results of esophagogastroduodenoscopy (EGD), 238 patients with acute pancreatitis. Patients were divided into two groups: patients with acute pancreatitis (173) and patients with pancreatic necrosis (65). Results: In the group of patients with acute pancreatitis in 71.1 % of patients were registered changes in the mucosa of the upper gastrointestinal tract. A 28.9 % of patients no changes were observed. 11.6 % had changes in the gastric mucosa. 23.1 % of patients had changes in the duodenal mucous membrane. Edema longitudinal fold was found in 31.2 % of all patients, as a result, in 6 % of patients it was impossible to visualize the papilla. In the group of patients with pancreatic necrosis, in 100 % were registered changes in the upper gastrointestinal tract. In 8.5 % of patients was found esophagitis, 32 % had gastric erosive changes, and in 50 % of cases detected gastroduodenitis. Conclusion: Specific treatment aimed at protecting gastrointestinal mucosa is required for all patients with pancreatic necrosis.

• References total 9 ⇓ :: .
  1. Багненко С.Ф., Толстой А. Д., Красногоров В. Д. и др. Острый панкреатит (Протоколы диагностики и лечения). - Анналы хирургической гепатологии, 2006. - Т. 11. - № 1. - с. 60-66.
  2. Бурневич С. З., Куликова В. М., Сергеева Н. А. и др. Диагностика и хирургическое лечение панкреонекроза. - Анналы хирургической гепатологии, 2006. - Т. 11. - № 4. - с. 10-14.
  3. Лысенко М. В., Девятов А. С., Урсов С. В. и др. Острый панкреатит: дифференцированная лечебно-диагностическая тактика. М: Литтерра; 2010; 192с.
  4. Toouli J., Brook-Smith M., Bassi C. et al. Guidelines for the management of acute pancreatitis // J GastroenterolHepatol. 2002; (Suppl 17): S 15-39.
  5. СавельевВ.С.ФилимоновМ.И., Бурневич С. З. Панкреонекрозы. М: Медицинское информационное агенство, 2008.264 с.
  6. Freeman M. L., Werner J., vanSantvoortH.C., Baron T. H. at al. Intervention for necrotizing pancreatitis: summary of a multidisciplinary concensus conference.Pancreas. 2012;41(8): 1176-1194.
  7. Ю.А. Нестеренко, В. В. Лаптев, С. В. Михайлусов. Диагностика и лечение деструктивного панкреатита. М: ООО «Бином - Пресс», 2004;304 с.
  8. Митьков В. В. Практическое руководство по ультразвуковой диагностике. Общая ультразвуковая диагностика, М: Видар - М, 2011, 712с.
  9. А. Е. Котовский, Г. А. Уржумцева, М. В. Яковенко, О. П. Примасюк и др. Изменения слизистой оболочки желудка и двенадцатиперстной кишки при панкреонекрозе., ХIХ Сьезд хирургов 2000, Волгоград, стр. 65.

Full text is published :
Zvereva A.A., Kotovsky A.E., Glebov K.G. ENDOSCOPIC CHANGES IN THE UPPER GASTROINTESTINAL TRACT IN PATIENTS WITH ACUTE PANCREATITIS AND PANCREATIC NECROSIS, TREATMENT AND FOLLOW-UP. Experimental and Clinical Gastroenterology Journal. 2017;140(04):22-26
Read & Download full text

1. Central clinical hospital of Administration of the President of the Russian Federation (Moscow, Russian Federation)

Keywords:Cholangiocarcinoma,cholangioscopy,confocal laser endomicroscopy,obstructive jaundicebile duct stones,pancreatic cancer

Abstract:An analysis of published data on the effectiveness of various methods of diagnosis of obstructive jaundice syndrome, caused by stones and bile duct strictures of various origins. We conducted an analysis of own data on the effectiveness and accuracy cholangioscopy and confocal laser confocal laser endomicroscopy (CLE) in the diagnosis of the causes of biliary obstruction. The efficacy of endoscopic retrograde cholangiopancreatography is considered in combination with additional methods of examination

• References total 20 ⇓ :: .
  1. Миниинвазивные вмешательства в лечении желчнокаменной болезни у больных пожилого и старческого возраста/ Н. И. Глушков и др.// Хирургия. - 2010. - № 10. - С. 53-58;
  2. Cha I. H., Kim J. N., Kim Y. S. Metastatic сommon bile duct cancer from pulmonary adenocarcinoma presenting as obstructive jaundice // Korean J. Gastroenterology 2013; 61 (1): 50-53;
  3. Гальперин Э. И. Стриктуры желчных протоков. В книге: Гальперин Э. И., Дюжева Т. Г. // Лекции по панкреатобилиарной хирургии под редакцией Э. И. Гальперина и Т. Г. Дюжевой. Москва: Видар - М; 2011;
  4. Moreno Luna L. E., Kipp В., Halling К. С. et al. Аdvanced cytologic techniques for the detection of malignant pancreatobiliary strictures // Gastroenterol. 2006; 131(4): 1064-1072;
  5. Taylor A. C., Liile A. F., Hennessy O. H. et al. Prospective blinded study of MRCP compared to ERCP and assessment of their respective clinical roles // Gastroenterol. 2000; 118: A 207;
  6. Parsi M. A. Peroral cholangioscopy-assisted guidewire placement for removal of impacted stones in the cystic duct remnant // W. J. Gastroenterol. 2009; 1(1): 59-61;
  7. Costamagna G., Tringali A., Mutignani M., et al. Endoscopic sphincterotomy for common bile duct stones: long-term follow-up and risk analysis for recurrence // Gastrointest. Endosc. 2000; 51: AB 189;
  8. Weber A., Schmid R. M., Prinz Ch. Diagnostic approaches for cholangiocarcinoma // W. J. Gastroenterol. 2008; 14(26): 4131-4136;
  9. Sharma M. P., Ahuja V. Aetiological spectrum of obstructive jaundice and diagnostic ability of ultrasonography: a clinician’s perspective // Trop. Gastroenterol. 1999; 20: 167-169;
  10. Гальперин Э. И. Стриктуры желчных протоков. В книге: Гальперин Э. И., Дюжева Т. Г. // Лекции по панкреатобилиарной хирургии под редакцией Э. И. Гальперина и Т. Г. Дюжевой. Москва: Видар - М; 2011;
  11. In Hye Cha, Jin Nam Kim, You Sun Kim et al. Metastatic Common Bile Duct Cancer from Pulmonary Adenocarcinoma Presenting as Obstructive Jaundice// Korean Journal of Gastroenterology. - 2013. - Vol. 61 No. 1, 50-53;
  12. Rösch T., Meining A., Frühmorgen S. et al. A prospective comparison of the diagnostic accuracy of ERCP, MRCP, CT, and EUS in biliary strictures // Gastrointest. Endosc. 2002; 55(7): 870-6;
  13. Яшина Н. И., Кармазановский Г. Г. Сложности диагностики рака головки поджелудочной железы при компьютерно-томографическом исследовании: Тез. Докл. XXXIX сессия ЦНИИГ. - Москва, 2013. - 168с.;
  14. Dumot J. A. ERCP: current uses and less-invasive options // Cleve Clin. J. Med. 2006; 73(5): 418-425;
  15. Ширяев С. В., Долгушин Б. И., Хмелев А. В. Современное состояние ПЭТ диагностики в онкологии: Доклад в рамках Заседания Московского Онкологического Общества; тема Позитронная эмиссионная томография. - Москва: 2009;
  16. Anderson C. D., Rice M. H., Pinson C. W., et al. Fluorodeoxyglucose PET imaging in the evaluation of gallbladder carcinoma and cholangiocarcinoma // J. Gastrointest. Surg. 2004; 8: 90-97;
  17. Reinhardt M. J., Strunk H., Gerhardt T., et al. Detection of Klatskin’s tumor in extrahepatic bile duct strictures using delayed 18F-FDG PET/CT: preliminary results for 22 patient studies // J. of Nucl. Med. 2005; 46: 1158-1163;
  18. Itoi T., Osanay M., Igarashi Y. et al. Diagnostic peroral video cholangioscopy is an accurate diagnostic tool for patients with bile duct lesions // Clin. Gastroenterol. Hepatol. 2010; 8(11): 934-8;
  19. Tischendorf J. J., Krüger M., Trautwein C. et al. Cholangioscopic characterization of dominant bile duct stenoses in patients with primary sclerosing cholangitis // Endosc. 2006; 38(7): 665-9;
  20. Da Silveira E. B., Barkun A. N., Romagnuolo J. et al. An economic evaluation from randomizae trial data comparing ERCP to MRCP in suspected biliary obstruction // Gastrointest. Endosc. 2007; 65: AB 95.

Full text is published :
Fomicheva N.V., Shuleshova A.G., Ulyanov D.N. DIAGNOSIS AND TREATMENT OF THE SYNDROME OF OBSTRUCTIVE JAUNDICE. Experimental and Clinical Gastroenterology Journal. 2017;140(04):27-33
Read & Download full text

1. Clinical hospital № 122 named after L. G. Sokolov (Moscow, Russian Federation)
2. Saint Petersburg state University (St. Petersburg, Russian Federation)
3. National medical surgical center n. a.. N. I. Pirogov (Moscow, Russian Federation)

Keywords:bile ducts stricture,ERCP,brush-biopsy,biopsy,EUS,fine needle aspiration,FNA,histology,cholangiocarcinoma,bile ducts cancer,choledoch,common bile duct

Abstract:An analysis of published data on the effectiveness of various methods of diagnosis of obstructive jaundice syndrome, caused by stones and bile duct strictures of various origins. We conducted an analysis of own data on the effectiveness and accuracy cholangioscopy and confocal laser confocal laser endomicroscopy (CLE) in the diagnosis of the causes of biliary obstruction. The efficacy of endoscopic retrograde cholangiopancreatography is considered in combination with additional methods of examination

• References total 52 ⇓ :: .
  1. Khan S. A., Thomas H. C., Davidson B. R., Taylor-Robinson S. D. Cholangiocarcinoma. Lancet, 2005, vol. 367, no. 9523, pp. 1303-1314.
  2. Razumilava N, Gores G. J. Cholangiocarcinoma. Lancet, 2014, vol. 383, no. 9935, pp. 2168-2179.
  3. Mosconi S et al. Cholangiocarcinoma. Crit Rev Oncol Hematol, 2009, vol. 69, no. 3, pp. 259-270.
  4. Lazaridis K. N., LaRusso N. F. The Cholangiopathies. Mayo Clin Proc, 2015, vol. 90, no. 6, pp. 791-800.
  5. Nanda A., Brown J. M., Berger S. H. et al. Triple modality testing by endoscopic retrograde cholangiopancreatography for the diagnosis of cholangiocarcinoma. Therap Adv Gastroenterol, 2015, vol. 8, no. 2, pp. 56-65.
  6. Sethi R., Singh K., Warner B. et al. The impact of brush cytology from endoscopic retrograde cholangiopancreatography (ERCP) on patient management at a UK teaching hospital. Frontline Gastroenterol, 2016, vol. 7, pp. 97-101.
  7. Kim J. Y., Choi J. H., Kim J. H. et al. Clinical usefulness of bile cytology obtained from biliary drainage tube for diagnosing cholangiocarcinoma. Korean J Gastroenterol, 2014, vol. 63, no. 2, pp. 107-13.
  8. Yagioka H., Hirano K., Isayama H. et al. Clinical significance of bile cytology via an endoscopic nasobiliary drainage tube for pathological diagnosis of malignant biliary strictures. J Hepatobiliary Pancreat Sci, 2011, vol. 18, no. 2, pp. 211-215.
  9. Nilsson B., Wee A., Yap I. Bile cytology. Diagnostic role in the management of biliary obstruction. Acta Cytol, 1995, vol. 39, no. 4, pp. 746-752.
  10. Noda Y., Fujita N., Kobayashi G. et al. Prospective randomized controlled study comparing cell block method and conventional smear method for bile cytology. Dig Endosc, 2013, vol. 25, no. 4, pp. 444-452.
  11. Mohandas K. M., Swaroop V. S., Gullar S. U. et al. Diagnosis of malignant obstructive jaundice by bile cytology: results improved by dilating the bile duct strictures. Gastrointest Endosc, 1994, vol. 40, no.2, pp. 150-154.
  12. Fior-Gozlan M., Bosio C., Croset C., Bichard P. Value of bile cytology associated with brush cytology of the bile duct: a comparative study of 115 patients. Ann Pathol, 2006, vol. 26, no. 5, pp. 361-367.
  13. Mahmoudi N., Enns R., Amar J. et al. Biliary brush cytology: Factors associated with positive yields on biliary brush cytology. World J Gastroenterol, 2008, vol. 14, no. 4, pp. 569-573.
  14. Eiholm S., Thielsen P., Kromann-Andersen H. Endoscopic brush cytology from the biliary duct system is still valuable. Dan Med J, 2013, vol. 60, no. 7, pp. A4656.
  15. Schoefl R., Haefner M., Wrba F. et al. Forceps biopsy and brush cytology during endoscopic retrograde cholangiopancreatography for the diagnosis of biliary stenoses. Scand J Gastroenterol, 1997, vol. 32, no. 4, pp. 363-368.
  16. Harewood G. C., Baron T. H., Stadheim L. M. et al. Prospective, blinded assessment of factors influencing the accuracy of biliary cytology interpretation. Am J Gastroenterol, 2004, vol. 99, no. 8, pp. 1464-1469.
  17. de Bellis M., Fogel E. L., Sherman S. et al. Influence of stricture dilation and repeat brushing on the cancer detection rate of brush cytology in the evaluation of malignant biliary obstruction. Gastrointest Endosc, 2003, vol. 58, no. 2, pp. 176-182.
  18. Roth G. S., Bichard P., Fior-Gozlan M. et al. Performance of bile aspiration plus brushing to diagnose malignant biliary strictures during endoscopic retrograde cholangiopancreatography. Endosc Int Open, 2016, vol. 4, no.9, pp. E 997-E 1003.
  19. Fogel E. L., deBellis M., McHenry L. et al. Effectiveness of a new long cytology brush in the evaluation of malignant biliary obstruction: a prospective study. Gastrointest Endosc, 2006, vol. 63, no. 1, pp. 71-77.
  20. Mehmood S., Loya A., Yusuf M. A. Biliary Brush Cytology Revisited. Acta Cytol, 2016, vol. 60, no. 2, pp. 167-172.
  21. Weber A., von Weyhern C., Fend F. et al. Endoscopic transpapillary brush cytology and forceps biopsy in patients with hilar cholangiocarcinoma. World J Gastroenterol, 2008, vol. 14, no. 7, pp. 1097-1101.
  22. Bang K. B., Kim H. J., Park J. H. et al. Comparison of brush and basket cytology in differential diagnosis of bile duct stricture at endoscopic retrograde cholangiopancreatography. Hepatobiliary Pancreat Dis Int, 2014, vol. 13, no. 6, pp. 622-627.
  23. Varadarajulu S., Bang J. Y., Hasan M. K. et al. Improving the diagnostic yield of single-operator cholangioscopy-guided biopsy of indeterminate biliary strictures: ROSE to the rescue? (with video). Gastrointest Endosc, 2016, vol. 84, no. 4, pp. 681-687.
  24. Heinzow H. S., Woestmeyer C., Domschke W. et al. Endoscopic transpapillary biopsies are of limited value in the diagnostics of bile duct strictures of unknown etiology-results of a histopathologically controlled study in 312 patients. Hepatogastroenterology, 2013, vol. 60, no. 127, pp. 1569-1572.
  25. Chen W. M., Wei K. L., Chen Y. S. et al. Transpapillary biliary biopsy for malignant biliary strictures: comparison between cholangiocarcinoma and pancreatic cancer. World J Surg Oncol, 2016, vol. 14, p. 140.
  26. Domagk D., Poremba C., Dietl K. H. et al. Endoscopic transpapillary biopsies and intraductal ultrasonography in the diagnostics of bile duct strictures: a prospective study. Gut, 2002, vol. 51, no. 2, pp. 240-244.
  27. Weber A., Schmid R. M., Prinz C. Diagnostic approaches for cholangiocarcinoma. World J Gastroenterol, 2008, vol. 14, no. 26, pp. 4131-4136.
  28. Ierardi A. M., Mangini M., Fontana F. et al. Usefulness and safety of biliary percutaneous transluminal forceps biopsy (PTFB): our experience. Minim Invasive Ther Allied Technol, 2014, vol. 23, no. 2, pp. 96-101.
  29. Tamada K., Kurihara K., Tomiyama T. et al. How many biopsies should be performed during percutaneous transhepatic cholangioscopy to diagnose biliary tract cancer? Gastrointest Endosc, 1999, vol. 50, no. 5, pp. 653-658.
  30. Shah R. J., Langer D. A., Antillon M. R., Chen Y. K. Cholangioscopy and cholangioscopic forceps biopsy in patients with indeterminate pancreaticobiliary pathology. Clin Gastroenterol Hepatol, 2006, vol.4, pp. 219-225.
  31. Kim H. J., Kim M. H., Lee S. K. et al. Tumor vessel: a valuable cholangioscopic clue of malignant biliary stricture. Gastrointest Endosc, 2000, vol. 52, no.5, pp. 635-638.
  32. Fukuda Y., Tsuyuguchi T., Sakai Y. et al. Diagnostic utility of peroral cholangioscopy for various bile-duct lesions. Gastrointest Endosc, 2005, vol. 62, no. 3, pp. 374-382.
  33. Itoi T., Osanai M., Igarashi Y. et al. Diagnostic peroral video cholangioscopy is an accurate diagnostic tool for patients with bile duct lesions. Clin Gastroenterol Hepatol, 2010, vol. 8, no. 11, pp. 934-938.
  34. Yang J. F., Sharaiha R. Z., Francis G. et al. Diagnostic accuracy of directed cholangioscopic biopsies and confocal laser endomicroscopy in cytology-negative indeterminate bile duct stricture: a multicenter comparison trial. Minerva Gastroenterol Dietol, 2016, vol. 62, no. 3, pp. 227-233.
  35. Chen Y. K., Pleskow D. K. SpyGlass single-operator peroral cholangiopancreatoscopy system for the diagnosis and therapy of bile-duct disorders: a clinical feasibility study (with video). Gastrointest Endosc, 2007, vol. 65, no. 6, pp. 832-841.
  36. Manta R., Frazzoni M., Conigliaro R. et al. SpyGlass single-operator peroral cholangioscopy in the evaluation of indeterminate biliary lesions: a single-center, prospective, cohort study. Surg Endosc, 2013, vol. 27, no. 5, pp. 1569-1572.
  37. Siddiqui A. A., Mehendiratta V., Jackson W. et al. Identification of cholangiocarcinoma by using the Spyglass Spyscope system for peroral cholangioscopy and biopsy collection. Clin Gastroenterol Hepatol, 2012, vol. 10, no. 5, pp. 466-471.
  38. Weilert F., Bhat Y. M., Binmoeller K. F. et al. EUS-FNA is superior to ERCP-based tissue sampling in suspected malignant biliary obstruction: results of a prospective, single-blind, comparative study. Gastrointest Endosc, 2014, vol. 80, no. 1, pp. 97-104.
  39. Nguyen K., Sing J. T. Jr. Review of endoscopic techniques in the diagnosis and management of cholangiocarcinoma. World J Gastroenterol, 2008, vol. 14, no. 19, pp. 2995-2999.
  40. Garrow D., Miller S., Sinha D. et al. Endoscopic ultrasound: a meta-analysis of test performance in suspected biliary obstruction. Clin Gastroenterol Hepatol, 2007, vol. 5, pp. 616-623.
  41. Nayar M. K., Manas D. M., Wadehra V., Oppong K. E. Role of EUS/EUS-guided FNA in the management of proximal biliary strictures. Hepatogastroenterology, 2011, vol. 58, pp. 1862-1865.
  42. Fritscher-Ravens A., Broering D. C., Knoefel W. T. et al. EUS-guided fine-needle aspiration of suspected hilar cholangiocarcinoma in potentially operable patients with negative brush cytology. Am J Gastroenterol, 2004, vol. 99, pp. 45-51.
  43. Eloubeidi M. A., Chen V. K., Jhala N. C. et al. Endoscopic ultrasound-guided fine needle aspiration biopsy of suspected cholangiocarcinoma. Clin Gastroenterol Hepatol, 2004, vol. 2, pp. 209-213.
  44. Tummala P., Munigala S., Eloubeidi M. A., Agarwal B. Patients with obstructive jaundice and biliary stricture ± mass lesion on imaging: prevalence of malignancy and potential role of EUS-FNA. J Clin Gastroenterol, 2013, vol. 47, pp. 532-537.
  45. Mohamadnejad M., Dewitt J. M., Sherman S. et al. Role of EUS for preoperative evaluation of cholangiocarcinoma: a large single-center experience. Gastrointest Endosc, 2011, vol. 73, pp. 71-78.
  46. Fletcher N. D., Wise P. E., Sharp K. W. Common bile duct papillary adenoma causing obstructive jaundice: case report and review of the literature. Am Surg, 2004, vol. 70, pp. 448-452.
  47. Penn I. Primary malignancies of the hepato-biliary-pancreatic system in organ allograft recipients. J Hepatobiliary Pancreat Surg, 1998, vol. 5, pp. 157-164.
  48. Gleeson F. C., Rajan E., Levy M. J. et al. EUS-guided FNA of regional lymph nodes in patients with unresectable hilar cholangiocarcinoma. Gastrointest Endosc, 2008, vol. 67, pp. 438-443.
  49. Pollack M. J., Gholam P. M., Chak A. EUS-FNA in unresectable cholangiocarcinoma: a novel indication. Gastrointest Endosc, 2008, vol. 67, pp. 444-445.
  50. El Chafic A. H., Dewitt J., Leblanc J. K. et al. Impact of preoperative endoscopic ultrasound-guided fine needle aspiration on postoperative recurrence and survival in cholangiocarcinoma patients. Endoscopy, 2013, vol. 45, pp. 883-889.
  51. Dumonceau J. M., Koessler T., van Hooft J. E., Fockens P. Endoscopic ultrasonography-guided fine needle aspiration: Relatively low sensitivity in the endosonographer population. World J Gastroenterol, 2012, vol. 18, no. 19, pp. 2357-2363.
  52. Curcio G., Traina M., Mocciaro F. et al. Intraductal aspiration: a promising new tissue-sampling technique for the diagnosis of suspected malignant biliary strictures. Gastrointest Endosc, 2012, vol. 75, no. 4, pp. 798-804.

Full text is published :
Solonitsyn E.G., Titov A.K., Vorobev S.L., Tamazyan N.V. et al. ENDOSCOPIC TECHNIQUES OF OBTAINING MATERIAL FOR MORPHOLOGICAL EXAMINATION FOR BILE DUCTS STRICTURES. Experimental and Clinical Gastroenterology Journal. 2017;140(04):34-40
Read & Download full text

1. Siberian State Medical University (Tomsk, Russian Federation)
2. Siberian Federal Sciene-Clinical Centre FMBA Russian Federation (Tomsk, Russian Federation)

Keywords:chronic cholecystitis,chronic opisthorchiasis,conjugate of clinical signs,the predictors of progression to cholecystitis

Abstract:Using contingency tables and logistic regression in clinical studies reveal the interconnectedness of all qualitative characteristics and predictors of disease progression. The results are natural and suggests that the indicators of liver function and biliary system activity in chronic cholecystitis combined with opisthorchiasis interrelated, interdependent and mutually. The results of complex statistical analysis can determine predictors of disease progression, which should be used for timely treatment and preventive measures aimed at the prevention of disease progression.

• References total 22 ⇓ :: .
  1. Ильченко А. А. Болезни желчного пузыря и желчных путей. М.: Медицинское информационное агентство; 2011, 880с.
  2. Лоранская И. Д. Функциональные расстройства билиарного тракта /Учебное пособие. М.: Форте принт: 2013, 92 с.
  3. Лоранская И. Д., Кукушкин М. Л., Панина Н. А. Билиарные дисфункции и их профилактика //Экспериментальная и клиническая гастроэнтерология. 2011; № 5: 48-52.
  4. Пальцев А. И., Дарянина С. А. Фитотерапия хронического описторхоза. Новосибирск: Изд-во СО РАН: 2004, 140 с.
  5. Полунина Т. Е. Алгоритм диагностики и лечения дисфункций билиарного тракта //Архивь внутренней медицины. 2015; № 1(21): 27-32.
  6. Минушкин О. Н. Сочетанные функциональные расстройства ЖКТ. Их диагностика и лечебные подходы // Медицинский совет. 2015; № 13: 20-25.
  7. Ардатская М. Д. Функциональные расстройства билиарного тракта: проблемы диагностики и лечения // Фарматека. 2012; № 2: 71-77.
  8. Плотникова Е. Ю., Александрова А. Ю., Белобородова Э. И. и др. Биохимические особенности состава пузырной желчи при патологии желчевыводящих путей //Клиническая лабораторная диагностика: научно-практический журнал. 2007; № 6: 33-36.
  9. Тюрюмин Я. Л. В Шантуров.А., Тюрюмина Е. Э. Патогенез и лечение холестеринового холецистолитиаза (обзор) //Бюллетень ВСНЦ СО РАМН. 2012; № 2 (84), Часть 2: 181-186.
  10. Кнышова В. В., Веремчук Л. В., Шейкина А. И. Взаимосвязь метаболических нарушений и функционального состояния печени при хроническом некалькулезном холецистите //Вестник новых медицинских технологий. 2011; Т.XVIII, № 3: 3-39.
  11. Абаев Ю. К. Клинические испытания в доказательной медицине //Медицинские новости. 2008; № 10: 7-14.
  12. Поддубная О. А. Сопряженность особенностей проведения комплексной физиотерапии с ее эффективностью у больных хроническим холециститом //Физиотерапия, бальнеология и реабилитация. 2014; № 6: 19-24.
  13. Пронин C. B., Егорова Л. С., Чухрова М. Г. и др. Соматоформные расстройства у пациентов с хроническим некалькулезным холециститом //Мир науки, культуры, образования. 2013; № 3 (40): 388-391.
  14. Камзеев Д. В. Прогностическое значение факторов риска церебрального инсульта у больных с функциональными, дегенеративно-дистрофическими нарушениями шейного отдела позвоночника и начальными проявлениями недостаточности кровоснабжения мозга //Автореф. Дис… канд. мед. наук. Казань. 2007, 32с.
  15. Истомина Н. Г. Предикторы эктопической беременности: исследование типа случай-контроль //Акушерство и гинекология. 2008; № 2: 31-34.
  16. Финк Г. Ф. Предикторы социальной адаптации при шизотипическом расстройстве //Вестник Смоленской медицинской академии. 2000; Вып.3: 115-116.
  17. Beaugerie L., Seksik P., Nion-Larmurier I. et al. Predictors of Crohn’s Disease //Gastroenterology. March 2006;130:650-656.
  18. Крупицкий Е. М., Борцов А. В. Парадигма доказательной медицины: принципы проведения клинических исследований //Журнал неврологии и психиатрии им. С. С. Корсакова. 2008; № 2: 9-12.
  19. Кендалл М., Стьюарт А. Статистические выводы и связи. Пер. с англ. М.: Главная редакция физ.-мат. литературы. 1973, 899 с.
  20. Леонов В. П. Обработка экспериментальных данных на программируемых микрокалькуляторах. Томск, изд-во ТГУ. 1990, 376с.
  21. David W. Hosmer. Jr., Stanley Lemeshow. Applied logistic regression- 2nd ed. John Wiley & Sons, Inc. 2000, 397 pp.
  22. McDowell S.E., Coleman J.J, Ferner R. E. Systematic review and meta-analysis of ethnic differences in risks of adverse reactions to drugs used in cardiovascular medicine. BMJ. May 20, 2006;332;1177-1181.

Full text is published :
Poddubnaya O.A. ANALYSIS OF CONTINGENCY FUNCTIONAL ACTIVITY OF HEPATOBILIARY SYSTEM IN CHRONIC CHOLECYSTITIS. Experimental and Clinical Gastroenterology Journal. 2017;140(04):41-47
Read & Download full text

1. Medical center “Yerevan” (Yerevan, Armenia)
2. Yerevan state medical University. M. Heratsi; Medical center “Nairi” (Yerevan, Armenia)

Keywords:calculous cholecystitis,high operative-anesthesiological risk,ultrasound,magnetic resonance imaging

Abstract:The article discusses current possibilities of visualization of the biliary tract in persons with calculous cholecystitis of the group’s high operational and anesthetic risk. According to the results of the comparative analysis of the main characteristics of such diagnostic methods as ultrasound, MRI and RPH the authors come to the conclusion about the benefits of magnetic resonance imaging. This method showed the greatest sensitivity and accuracy in detecting calculous cholecystitis patients with high operative-anesthesiological risk.

• References total 6 ⇓ :: .
  1. Никитин А. Д. Место ультразвукового исследования в диагностике заболеваний желчного пузыря // Бюллетень медицинских Интернет-конференций. - 2013. - Т. 3, № 2. - С. 204
  2. Ратников В. А., Черемисин В. М., Шейко С. Б. Современные лучевые методы (ультразвуковое исследование, рентгеновская компьютерная и магнитно-резонансная томография) в диагностике холедохолитиаза (обзор литературы) // Медицинская визуализация. - 2002. - № 3. - С. 99-106
  3. Рогожникова А. В., Климашин Д. Ф., Клименко Г. А. Информативность магнитно-резонансной томографии (МРТ) диагностики при выявлении заболеваний панкреато-билиарной зоны // Бюллетень медицинских Интернет-конференций. - 2013. - Т. 3, № 3. - С. 789
  4. Скирда И. Ю., Гладун В. М., Закревская О. В. Точность методов визуализации в диагностике острого холецистита // Гастроэнтерология. - 2015. - № 1 (55). - С. 31-41
  5. Тарасенко Л. А., Литвиненко И. В., Мандриченко А. С., Ерков А. А. Ультразвуковое исследование в диагностике остро калькулезного холецистита // Медицинская наука и образование Урала. - 2008. - № 1. - С. 34-36
  6. Imaging in Hepatobiliary and Pancreatic Disease. A Practical Clinical Approach / Ed. by van Leeuwen D. J., Reeders J. W.A.I., Ariyama J. Harcourt Publishers Limited, 2000. 525 p.

Full text is published :
Balayan G.Z., Gomtsyan N.A., Gomtsyan N.A., Ghalumyan K.S. et al. THE EFFECTIVENESS OF DIFFERENT IMAGING MODALITIES IN THE DIAGNOSIS OF CALCULOUS CHOLECYSTITIS IN PATIENTS WITH HIGH OPERATIVE-ANESTHESIOLOGICAL RISK. Experimental and Clinical Gastroenterology Journal. 2017;140(04):48-51
Read & Download full text

1. Kyrgyz-Russian Slavic University named after B. N. Yeltsin (Bishkek, Kyrgyzstan)

Keywords:single-voxel proton spektoroskopiya,focal lesions of the liver

Abstract:Purpose of the study - to assess the effectiveness of the diagnostic use of proton spectroscopy in focal lesions of the liver parenchyma. Material and methods: A 160 of the abdominal cavity of patients with focal lesions of the liver (36 patients - liver cancer (including cases of cholangiocarcinoma and cirrhosis, cancer); 28 patients - with single and multiple metastases in the liver parenchyma; 45 observation of single and multiple hemangiomas of the liver, 31 cases of infiltrative and cystic forms alveokokkovogo infiltrative lesion, 20 patients with liver parenchyma unchanged in the control group). The scanning protocol that included MR proton spectroscopy. The studies were conducted on the unit Philips Infinion 1,5T. In the spectrograms of proton spectra and tables were evaluated: height of the peaks; peak area; creatinine ratio of peak area to other metabolites; creatinine ratio of peak area to other metabolites; percentage of metabolites in the spectrum, represented as a relative value. Conclusion: The single-voxel proton spektoroskopiya has the potential to be used as differential diagnostic criteria of focal hepatic lesions.

• References total 8 ⇓ :: .
  1. Труфанов Г. Е., Тютин Л. А. Магнитно-резонансная спектроскопия. Санкт-Петербург: «Элби-Спб», 2008, 337 с.
  2. Лундин А.Г, Федин Э. И. ЯМР спектроскопия. М: Наука. 1986; 223 с.
  3. Подопригора А. Е., Пронин И. Н., Фадеева Л. М. Протонная магнитно резонансная спектроскопия в диагностике опухолевых и неопухолевых поражений головного мозга // Мед. виз. 2000. № 4. С. 86-92.
  4. Simmons M. L., Frodonza C. G. and Coyle J. T. Immunocytochemical localization of N-acetyl-aspartate with monoclonal antibodies. Neuroscience. 1991; 45: 37745.
  5. Семенова Н. А. Метод ЯМР спектроскопии в прижизненных исследованиях обменных процессов. Особенности энергетического метаболизма головного мозга по данным ЯМР in vivo. Успехи современной биологии РАН. 2005; 125: 419-430.
  6. Bulakbasia N., Kocaoglua M., Цrsa F. et al. Combination of Single Voxel Proton MR Spectroscopy and Apparent Diffusion Coefficient Calculation in the Evaluation of Common Brain Tumors // Am. J. Neuroradiol. 2003. V.24. P. 225-233.
  7. Семенова Н. А., Ахадов Т. Ф., Ситников С. Л., Варфоломеев С. Д. Перспективы магнитно-резонансной спектроскопии как метода диагностики в невропатологии // Медицинская визуализация, № 2, 2009, с 73-81.
  8. Ложкин С. Н., Тиканадзе А. Д. Тюрюмина М. И. Глутамин и его роль в интенсивной терапии. Вестник интенсивной терапии, - 2003 № 4. Клиническое питание.

Full text is published :
Bebezov B.H., Bogdanov A.V., Sabirov I.S., Sabirov I.S. THE POSSIBILITY OF USING THE PROTON SPECTROSCOPY AT FOCAL LESIONS OF THE LIVER PARENCHYMA. Experimental and Clinical Gastroenterology Journal. 2017;140(04):52-57
Read & Download full text

1. FGBOU SPE Russian Medical Academy of Postgraduate Education (Moscow, Russian Federation)

Keywords:chronic abdominal syndrome,erosions and ulcers of the stomach and duodenum

Abstract:Aim of study was determination of especially clinic and diagnostic erosive and ulcerative lesions of gastroduodenal zone in patients with abdominal angina. Materials and Methods. Results of diagnostic and treatment 96 patients with abdominal angina. Results. Upper gastrointestinal endoscopy revealed erosive lesions in 44 cases, the bulb ulcers - in 3 cases, diffuse atrophy of the mucous - in 43 cases, focal gastropathy - in 53 cases.

• References total 35 ⇓ :: .
  1. Губергриц Н. Б., Агапова Н. Г. Абдоминальный ишемический синдром // Doktor. - 2004. - № 3. - С. 7-11.
  2. Калинин А. В., Степуро Д. К., Корнеев Н. В. и др. Хронический абдоминальный ишемический синдром и сочетанные с ним заболевания: особенности клиники, диагностики и лечения// Клинические перспективы гастроэнтерологии, гепатологии. - 2003. № 6С.19-23.
  3. Звенигородская Л. А., Н. Г. Самсонова, Топорков А. С. Хроническая ишемическая болезнь органов пищеварения: алгоритм диагностики и лечения // Фарматека. - 2010. - № 2. - С. 78-82.
  4. Логинов A. C., Звенигородская Л. А. Хроническая абдоминальная ишемия // Терапевт, арх, 2000. - J&2. - С. 36-40.
  5. Покровский А. В., Казанчян П. О., Гринберг А. А. и др. Функционально-морфологическое состояние желудочно-кишечного тракта в условиях хронических циркуляторных расстройств// Тер. арх. - 1983. - № 2. - С. 93-6.
  6. Клиническая ангиология /Под ред. академика РАМН А. В. Покровского. - Т. 2. - М.: Медицина, 2004. - 887 с.
  7. Луканов В. В., Фомина И. Г., Георгадзе З. О. и др. Трудности диагностики острых сосудистых заболеваний брюшной полости// Клин. мед. - 2005. - № 5. - С. 61-65.
  8. Ойноткинова О. Ш., Немытин Ю. В. Атеросклероз и абдоминальная ишемическая болезнь // М.: Медицина, 2001. - 312 с.
  9. Сохач А. Я. Причины возникновения и основные патогенетические механизмы развития атеросклеротической абдоминальной ишемической болезни// Медицинский вестник Северного Кавказа. - 2007. - № 4. - С. 3-8.
  10. Яковлев В. М., Хайт Г. Я., Сохач А. Я. Атеросклеротичекая абдоминальная ишемическая болезнь (патогенез, клиника, диагностика)//М.: «УИЦ XXI век», 2009. - 166.
  11. Plonka A. J. Atherosclerotic narrowings of themesenteric circulation/AJ Plonka, T. Tolloczko, M. Lipski et al. // Vac Surg. - 1989. - Vol. 92. - P. 202-5.
  12. Игнашов А. М., Канаев А. И., Курков А. А., Перлей В. Е., Новикова А. С. Компрессионный стеноз чревного ствола у детей и подростков (клиника, диагностика и хирургическое лечение) // Вестник хирургии. 2004. № 5. С. 78-81.
  13. Игнашов А. М., Тюрина Т. В., Перлей В. Е. и др. Хроническая рецидивирующая боль в животе и нейровегетативные расстройства у детей и подростков при синдроме компрессии чревного ствола // Амбулаторная хирургия. 2006. № 1 (21). С. 18-21.
  14. Вовк А. В., Шугаев А. И., Бабкин В. Я. Острые нарушения мезентериального кровообращения в неотложной хирургии органов брюшной полости// Вестн. хир. - 2006. - № 6. - С. 87-88.
  15. Гавриленко А. В., Косенков А. Н. Диагностика и хирургическое лечение хронической абдоминальной ишемии. М.: Медицина. 2000. - 169 с.
  16. Петровский Б. В., Гавриленко А. В. Хроническая абдоминальная ишемия: 35-летний опыт хирургического лечения // Анналы хирургии. - 2003. - № 3. - С. 10-14.
  17. Соколович Л. Г. Сосудистая хирургия и ангиология // Д: Феникс; Красноярск: Издательские проекты, 2006. - 176с.
  18. Libicher M., Reichert V., Fleksic M. et al. Balloon Occlusion of the Celiac Artery: A Test for Evaluation of Collateral Circulation Prior Endovascular Coverage // European Journal of Vascular and Endovascular Surgery. - 2008. - V. 36, № 3. - P. 303-305.
  19. Carr S. C., Mahvi D. M., Hoch J. R. et al. Visceral artery aneurysm rupture //J. Vasc. Surg. - 2001. - V. 33, № 4. - P. 806-811.
  20. Bacelli G. Aneurisma dell\’arteria mesenterica superiore/G. Bacelli//Policlinico Soz Med. - 1914. - N 11. - P. 301-3.
  21. Mitchell E. L., Chang E. Y., Landry G. J. et al. Duplex criteria for native superior mesenteric artery stenosis overestimate stenosis in stented superior mesenteric arteries // J. Vase. Surg. 2009; 50(2): 335-40.
  22. Аруин Л. И., Капуллер Л. Л., Исаков В. А. Морфологическая диагностика болезней желудка и кишечника. М.: Триада-Х. 1998. 483 с.
  23. Канаев А. И., Игнашов А. М. Клиника, диагностика, лечение синдрома компрессии чревного ствола //Вестник Санкт-Петербургской государственной медицинской академии им. акад. И. И. Мечникова. 2006. № 3. С. 125-129.
  24. Острая интестинальная ишемия: диагностика и хирургическое лечение / А. А. Баешко, В. В. Климович, В. А. Юшкевич и др. // Новые технологии в медицине: диагностика, лечение, реабилитация. - 2002. - С. 48-50.
  25. Комиссаров И. А., Игнашов А. М., Комаров К. М. Хронические боли в животе у детей. Возможные причины и лечение // Детская хирургия. 2006. № 3. С. 19-23.
  26. Шульпекова Ю. О., Драшганя О. М., Ивашкин В. Т. Абдоминальный болевой синдром//Рос. журнал гастроэнтерологин, гепатологии, колопроктологии. - 2002. С. 8-15.
  27. Ischemic gastropathy Jeopard sjcin in the stomach / T.C, Lee et al. // Endoscopy - 2005 - Vol, 37, N 9 - P 927.
  28. Kolkman J. J., Bargeman M., Huisman A. B., Geelkerken R. H. Diagnosis and management of splanchnic ischemia // World J. Gastroenterol. - 2008 Dec 28. - 14(48). - 7309-20.
  29. Mensink P. B., Moons L. M., Kuipers E. J. Chronic gastrointestinal ischaemia: shifting paradigms // Gut. - 2010 Nov 29. - P. 112-118.
  30. Лазебник Л. Б., Звенигородская Л. А. Хроническая ишемическая болезнь органов пищеварения. - 2003. - 136 с.
  31. Поташов Л. В., Князев М. В., Игнашов А. М. Ишемическая болезнь органов пищеварения. Л.: Медицина. 1985. 216 с.
  32. Савельев В. С. Петухов В. А., Бычков С. Г. и др. Нарушения микроциркуляции при хронической ишемической болезни органов пищеварения и дислипопротеидемии // Грудная и сердечно-сосуд. хирургия. - 1999. - No 4. - С. 40-45.
  33. Кохан Е. П., Белякин С. А., Иванов В.А и др. Диагностика и хирургические методы лечения больных хронической абдоминальной ишемией // Ангиология и сосудистая хирургия. - 2010. - № 4. - С. 135-138.
  34. Щербюк А. Н., Кондрашин С. А., Зайцев А. Ю. Малоинвазивные технологии в диагностике и лечении заболеваний магистральных артерий// Хирургия. - 2005. - № 3. - С. 10-17.
  35. Kruger A. J., Walker P. J., Foster W. J. et al. Open surgery for atherosclerotic chronic mesenteric ischemia//J Vase Surg. - 2007. - Vol. 46(5). - P. 941-945.

Full text is published :
Chernekhovskaya N.E., Povalyaev A.V., Oynotkinova O.Sh., Andreev V.G. et al. EROSIVE AND ULCERATIVE LESIONS OF GASTRODUODENAL ZONE IN PATIENTS WITH ABDOMINAL ANGINA. Experimental and Clinical Gastroenterology Journal. 2017;140(04):58-63
Read & Download full text

1. Moscow Cancer Research Institute (Moscow, Russian Federation)

Keywords:chronic abdominal syndrome,erosions and ulcers of the stomach and duodenum

Abstract:Majority of published data describing endocytoscopic examination of upper gastrointestinal tract mucosa, but in recent publications, it is reported, that endocytoscopy is suitable for small bowel, colon, respiratory tract and even peritoneum «optical biopsy». In number of articles possibilities of celiac sprue diagnostics with endocytoscopy is dicscussed, but small-bowel endocytoscopy is limited, due to absence of endocytoscopes, compatible with enteroscopes. More widely endocytoscopy is used in colon, mostly in lateral-spreading adenomas diagnostics. Prof. S-E. Kudo developed endocytoscopic classification of colonic mucosa changes, used for differential diagnostics and lesion mapping, describing hyperplasia, adenomas with different grades of intraepithelial neoplasia, non-invasive and invasive cancer. Some authors reported about good possibilities of endocytoscopy in inflammatory bowel disease diagnostics. Most of data, related to respiratory tract endocytoscopic examination, focused on precancerous conditions and early pharyngeal and lung cancer, and the preliminary results are promising, but, unfortunately, for now, endocytoscopy in bronchial tree is limited, due to lack of thin endocytoscopes. According to some article data, it is possible to use endocytoscopy not only in gastrointestinal and respiratory tract, but also in optical confirmation of peritoneal tumor dissemination in gastric and ovarian cancer patients, and - in bladder mucosa examination.

• References total 34 ⇓ :: .
  1. Inoue H, Kudo SE, Shiokawa A. (2005) in Vivo Imaging of Living Cancer Cell and Evaluation for Tissue Atypia Using Endocytoscopy: ECA (Endocytoscopic Atypia) Classification in the Esophagus and Stomach
  2. Clin Gastroenterol Hepatol. Jul;3(7 Suppl 1): S 61-3.
  3. Kudo S, Sasajima K, Inoue H et al. (2007) [Recent progress in endocytoscopy system: Classification of endocytoscopy]. Nihon Naika Gakkai Zasshi.Feb 10;96(2):252-65. Review
  4. Matysiak-Budnik, T., Coron, E., Mosnier, J. F., Le Rhun, M., Inoue, H., & Galmiche, J. P. (2010). In vivo real-time imaging of human duodenal mucosal structures in celiac disease using endocytoscopy. Endoscopy, 42, 191-196. doi:10.1055/s-0029-1243838
  5. West J, Logan RF, Hill PG, et al. (2007) The iceberg of celiac disease: what isbelow the waterline? Clin Gastroenterol Hepatol;5:59-62).,
  6. Pohl, H., Rösch, T., Tanczos, B. T., Rudolph, B., Schlüns, K., & Baumgart, D. C. (2009). Endocytoscopy for the detection of microstructural features in adult patients with celiac sprue: a prospective, blinded endocytoscopy-conventional histology correlation study. Gastrointestinal Endoscopy, 70(5), 933-941. doi:10.1016/j.gie.2009.04.043
  7. Rao, G. V., Mansard, M. J., Rebala, P., Sekaran, A., & Reddy, D. N. (2009). Endocytoscopy assisted laparoscopic intraoperative diagnosis of disseminated malignancy. Surgical Endoscopy and Other Interventional Techniques, 23, 2395-2396. doi:10.1007/s00464-009-0365-y
  8. Watanabe D et al. (2013) Endocytoscopy provides an in vivo virtual histo- pathological diagnosis of Whipple’s disease, 45, 143-144. Endoscopy, 45, 2013, E 143-144
  9. Neumann, H. (2013). Real-time in vivo histologic examination using a probe-based endocytoscopy system for differentiating duodenal polyps, Endoscopy, 45, 53-54.
  10. Shiwaku, H., Kudo, S., Ikehara, N., Ohtsuka, K., Ogata, N., Wakamura, K. (2010). Use of endocytoscopy in the diagnosis of a rare, depressed-type ileal adenoma. Endoscopy, 42, 326-327. doi:10.1055/s-0030-1255890
  11. Fasoli, A., Pugliese, V., Gatteschi, B., Spina, B., Munizzi, F., Frascio, F., … Meroni, E. (2008). Endocytoscopic imaging of a carcinoid tumor. Gastrointestinal Endoscopy, 68(5), 1015-1017. doi:10.1016/j.gie.2008.02.039
  12. Scherübl, H., Jensen, R. T., Cadiot, G., Stölzel, U., & Klöppel, G. (2010). Neuroendocrine tumors of the small bowels are on the rise: Early aspects and management. World Journal of Gastrointestinal Endoscopy, 2(10), 325-334. doi:10.4253/wjge.v2.i10.325
  13. Kwon, R. S., Wong Kee Song, L.-M., Adler, D. G., Conway, J. D., Diehl, D. L., Farraye, F. a, … Tierney, W. M. (2009). Endocytoscopy. Gastrointestinal Endoscopy, 70(4), 610-613. doi:10.1016/j.gie.2009.06.030
  14. Liu HH, Kudo SE, Juch JP. (2005) Pit pattern analysis by magnifying chromoendoscopy for the diagnosis of colorectal polyps. J Formos Med Assoc. 2003 Mar;102(3):178-82.
  15. Hewett DG, Kaltenbach T, Sano Y, Tanaka S, Saunders B, Ponchon T, Soetikno R, Rex DK. (2012) Validation of a Simple Classification System for Endoscopic Diagnosis of Small Colorectal Polyps Using Narrow-Band Imaging. Gastroenterology. May 15).
  16. Sasajima, K., Kudo, S. E., Inoue, H., Takeuchi, T., Kashida, H., Hidaka, E., … Shiokawa, A. (2006). Real-time in vivo virtual histology of colorectal lesions when using the endocytoscopy system. Gastrointestinal Endoscopy, 63(7), 1010-1017. doi:10.1016/j.gie.2006.01.021
  17. Kudo, S. E., Wakamura, K., Ikehara, N., Mori, Y., Inoue, H., & Hamatani, S. (2011). Diagnosis of colorectal lesions with a novel endocytoscopic classification a pilot study. Endoscopy, 43, 869-875. doi:10.1055/s-0030-1256663
  18. Cipolletta, L. (2009). Endocytoscopy can identify dysplasia in aberrant crypt foci of the colorectum: a prospective in vivo study. Endoscopy, 41, 129-132. doi:10.1055/s
  19. Rotondano, G., Bianco, M. A., Salerno, R., Meucci, C., Prisco, A., Garofano, M. L., … Cipolletta, L. (2010). Endocytoscopic classification of preneoplastic lesions in the colorectum. International Journal of Colorectal Disease, 25, 1111-1116. doi:10.1007/s00384-010-0969-7
  20. Mori, Y., Kudo, S., Ikehara, N., Wakamura, K., Wada, Y., Kutsukawa, M., … Hamatani, S. (2013). Comprehensive diagnostic ability of endocytoscopy compared with biopsy for colorectal neoplasms: A prospective randomized noninferiority trial. Endoscopy, 45, 98-105. doi:10.1055/s-0032-1325932
  21. Mori, Y., Kudo, S., Wakamura, K., & Misawa, M. (2014). Novel computer-aided diagnostic system for colorectal lesions by using endocytoscopy (with videos). Gastrointestinal Endoscopy, 1-9. doi:10.1016/j.gie.2014.09.008
  22. Yan, B. (2008). In vivo real-time endocytoscopic visualization of blood flow in rectal microvasculature. Endoscopy, 4, 534-536. doi:10.1055/s
  23. Bessho, R., Kanai, T., Hosoe, N., Kobayashi, T., Takayama, T., Inoue, N., … Hibi, T. (2011). Correlation between endocytoscopy and conventional histopathology in microstructural features of ulcerative colitis. Journal of Gastroenterology, 1-6. doi:10.1007/s00535-011-0439-1
  24. Hosoe, N., Kobayashi, T., Kanai, T., & Bessho, R. (2010). In vivo visualization of trophozoites in patients with amoebic colitis by using a newly developed endocytoscope. YMGE, 72(3), 643-646. doi:10.1016/j.gie.2010.04.031
  25. Shimizu, Y., Takahashi, M., Yoshida, T., Ono, S., Mabe, K., Kato, M., … Sakamoto, N. (2013). Endoscopic in vivo cellular imaging of superficial squamous cell carcinoma of the head and neck by using an integrated endocytoscopy system (with video). Gastrointestinal Endoscopy, 78(2), 351-358. doi:10.1016/j.gie.2013.03.1336
  26. Inoue, H. (2006). Endoscopic in vivo evaluation of tissue atypia in the esophagus using a newly designed integrated endocytoscope: a pilot trial. Endoscopy, 38(January), 891-895. doi:10.1055/s
  27. Shibuya, K., Fujiwara, T., Yasufuku, K., Alaa RM, M., Chiyo, M., Nakajima, T., … Yoshino, I. (2011). In vivo microscopic imaging of the bronchial mucosa using an endo-cytoscopy system. Lung Cancer, 72(2), 184-190. doi:10.1016/j.lungcan.2010.08.006
  28. Nosaka, S., Kurimoto, N., & Morita, K. (2014). Endocytoscopy and Narrow Band Imaging for Super fi cial Extension of Squamous Cell Carcinoma. The Annals of Thoracic Surgery, 98(3), 1117. doi:10.1016/j.athoracsur.2014.05.053
  29. Scherübl, H., Jensen, R. T., Cadiot, G., Stölzel, U., & Klöppel, G. (2010). Neuroendocrine tumors of the small bowels are on the rise: Early aspects and management. World Journal of Gastrointestinal Endoscopy, 2(10), 325-334. doi:10.4253/wjge.v2.i10.325
  30. Ohigashi T (2006) In vivo observation of living bladder cancer cells using catheter-type contact ultra-magnifying endoscope UROLOGY 68 (Supplement 5A), November 2006, p.39
  31. Rao, G. V. (2007). Endocytoscopy assists in the intraoperative diagnosis of carcinoma in a patient with chronic pancreatitis. Endoscopy, 39, 317-318. doi:10.1055/s
  32. Rao, G. V., Mansard, M. J., Rebala, P., Sekaran, A., & Reddy, D. N. (2009). Endocytoscopy assisted laparoscopic intraoperative diagnosis of disseminated malignancy. Surgical Endoscopy and Other Interventional Techniques, 23, 2395-2396. doi:10.1007/s00464-009-0365-y
  33. Muto, M. (2007) Endoscopic Molecular Imaging of Gastrointestinal Neoplasm: A Pilot Study GASTROINTESTINAL ENDOSCOPY Volume 65, No. 5: 2007 AB 124
  34. Sumiyama, K., Tajiri, H., Kato, F., Imura, T., Ono, K., Ikeda, K., … Gostout, C. J. (2009). Pilot study for in vivo cellular imaging of the muscularis propria and ex vivo molecular imaging of myenteric neurons (with video). Gastrointestinal Endoscopy, 69(6), 1129-1134. doi:10.1016/j.gie.2008.08.007

Full text is published :
Pirogov S.S., Sokolov V.V., Kaprin A.V., Sokolov D.V. et al. ENDOCYTOSCOPY - NEW TYPE OF ENDOSCOPIC EXAMINATION OF LOWER GASTROINTESTINAL AND RESPIRATORY TRACT (PART 3). Experimental and Clinical Gastroenterology Journal. 2017;140(04):64-72
Read & Download full text

1. Peoples’ Friendship University of Russia (Moscow, Russian Federation)

Keywords:malignant large bowel obstruction,colorectal stenting,self-expanding metal stents,SEMS

Abstract:Literature review on colorectal stenting in malignant large bowel obstruction in comparison with surgery in different clinical situations supplemented by own retrospective analysis of stenting (56 patients) versus palliative surgery (50 patients) was performed. Stenting demonstrated lower levels of early complications (3,6 % / 22 %) and in-hospital mortality (1,8 % / 18 %) as compared with surgical palliation (p<0,01) with similar long-term results and therefore was recommended as preferred final palliation in incurable patients.

• References total 14 ⇓ :: .
  1. Dohmoto M., Rupp K. D., Hohlbach G. Endoscopically-implanted prosthesis in rectal carcinoma // Dtsch. Med. Wochenschr. - 1990. - Vol. 115 (23). - P. 915.
  2. Baron T. H., Wong Kee Song L. M., Repici A. Role of self-expandable stents for patients with colon cancer // Gastointest. Endosc. - 2012. - Vol. 75 (3). - P. 653-662.
  3. Pirlet I. A., Slim K., Kwiatkowski F., et al. Emergency preoperative stenting versus surgery for acute left-sided malignant colonic obstruction: a multicenter randomized controlled trial // Surg. Endosc. - 2011. - Vol. 25. - P. 1814-21.
  4. Van Hooft J. E., Bemelman W. A., Oldenburg B., et al. Colonic stenting versus emergency surgery for acute left-sided malignant colonic obstruction: a multicenter randomized study // Lancet Oncol. - 2011. - Vol. 12 (4). - P. 344-352.
  5. Alcántara M., Serra-Aracil X., Falcó J., et al. Prospective, controlled, randomized study of intraoperative colonic lavage versus stent placement in obstructive left-sided colonic cancer // World J. Surg. - 2011. - Vol. 35 (8). - P. 1904-1910.
  6. Huang X., Lv B., Zhang S., Meng L. Preoperative colonic stents versus emergency surgery for acute left-sided malignant colonic obstruction: a meta-analysis // J. Gastrointest. Surg. - 2014. - Vol. 18 (3). - P. 584-591.
  7. Gorissen K. J., Tuynman J. B., Fryer E., et al. Local recurrence after stenting for obstructing left-sided colonic cancer // Br. J. Surg. - 2013. - Vol. 100 (13). - P. 1805-1809.
  8. Sloothaak D. A.M., van den Berg M. W., Dijkgraaf M. G.W., et al. Oncological outcome of malignant colonic obstruction in the Dutch Stent-In 2 trial // Br. J. Surg. - 2014. - Vol. 101 (31). - P. 1751-1757.
  9. Van Hooft J. E., van Halsema E. E., Vanbiervliet G., et al. Self-expandable metal stents for obstructing colonic and extracolonic cancer: European Society of Gastrointestinal Endoscopy (ESGE) clinical guideline // Endoscopy. - 2014. - Vol. 46. - P. 990-1002.
  10. Matsuda A., Miyashita M., Matsumoto S., et al. Comparison of long-term outcomes of colonic stent as “bridge to surgery” and emergency surgery for malignant large-bowel obstruction: a meta-analysis // Ann. Surg. Oncol. - 2015. - Vol. 22 (2). - P. 497-504.
  11. Erichsen R., Horváth-Puhó E., Jacobsen J. B., et al. Long-term mortality and recurrence after colorectal cancer surgery with preoperative stenting: a Danish nationwide cohort study // Endoscopy. - 2015. - Vol. 47. - P. 517-524.
  12. Zhao X. D., Cai B. B., Cao R. S., Shi R. H. Palliative treatment for incurable malignant colorectal obstructions: a meta-analysis // World J. Gastroenterol. - 2013. - Vol. 19 (33). - P. 5565-5574.
  13. Liang T. W., Sun Y., Wei Y. C., Yang D. X. Palliative treatment of malignant colorectal obstruction caused by advanced malignancy: a self-expanding metallic stent or surgery? A system review and meta-analysis // Surg. Today. - 2014. - Vol. 44 (1). - P. 22-33.
  14. Takahashi H., Okabayashi K., Tsuruta M., et al. Self-expanding metallic stents versus surgical intervention as palliative therapy for obstructive colorectal cancer: a meta-analysis // World J. Surg. - 2015. - Vol. 39(8). - P. 2037-2044.

Full text is published :
Fedorov A.G., Davydova S.V., Klimov A.E. COLORECTAL STENTING VERSUS SURGERY IN MALIGNANT LARGE BOWEL OBSTRUCTION. Experimental and Clinical Gastroenterology Journal. 2017;140(04):73-75
Read & Download full text

1. Center of cosmetology and plastic surgery n. a. S. V. Nudelman (Moscow, Russian Federation)

Keywords:colonoscopy,cleansing,macrogol

Abstract:Based on the study results of 64 patients colonoscopy the use of brackish water “Longevity” solvent 15-20 % improvement in quality of preparation of the intestinal mucosa by colonoscopy when using traditional one-stage schemes with products based on macrogol, facilitates bowel cleansing in patients suffering from chronic constipation, and does not require increasing doses of drugs based on macrogol.

Full text is published :
Ivantsova M.A., Airapetov E.L., Oshchepkov V.A. THE USE OF BRACKISH WATER “LONGEVITY” AS A SOLVENT TO IMPROVE BOWEL CLEANSING FOR COLONOSCOPY. Experimental and Clinical Gastroenterology Journal. 2017;140(04):76-78
Read & Download full text

1. Orenburg State Medical University (Orenburg, Russian Federation)
2. City Clinical Hospital named after NI Pirogov (Orenburg, Russian Federation)

Keywords:Ileocecal sphincter,microsurgery,restorative operation

Abstract:In order to justify the possibility of performing microsurgical restorative operations on the ileocecal valve 151 objects (21 dogs and 130 corpses of people) were examined. Two series of experiments were carried out: intraluminal sphincteroplastics of the bauhin’s valve by microsurgical technique was per-formed on 12 animals and traditional technique was used in 9 dogs. The restorative operation was made on the 8th day after creating the model of the ileocecal valve insufficiency. On the basis of the obtained data on the morphological characteristics, morphometrical parameters and microsurgical anatomy of the ileocecal valve a mode of intraluminal correction of the ileocecal valve insufficiency has been developed by using microsurgical methods. New findings on the dynamics of healing of the ileocecal sphincter in different terms after restorative operation by microsurgical technique were obtained, morphological and functional characteristics of the ileocecal sphincter in different terms after the operation were defined. The received data show that the use of microsurgical technique in per-forming the restorative operation on the ileocecal sphincter makes it possible to improve the results of the operation thanks to the restoration of sphincter and antireflux properties. The risk of development of incompetent sutures is minimized due to favorably proceeding reparative processes.

• References total 9 ⇓ :: .
  1. Витебский Я. Д. Очерки хирургии илеоцекального отдела кишечника/ Я. Д. Витебский. - М.: Медицина, 1973. -111 с.
  2. Дубяга А. Н. О диагностике и лечении рефлюкс-илеита / А. Н. Дубяга, Б. К. Гиберт // Вестн. хирургии. - 1980. - № 1. - С. 49-53.
  3. Каган И. И. Микрохирургический кишечный шов: способы и морфологические основы (обзор литературы) / И. И. Каган, И. Р. Иджян // Клиническая анатомия и экспериментальная хирургия: ежегодник Российской ассоциации клинических анатомов. - 2003. - Вып. 3. - С. 81-86.
  4. Коновалов Д. Ю. Экспериментальное и анатомическое обоснование микрохирургической техники реконструктивных операций на внепеченочных желчных путях: дис. … канд. мед. наук / Д. Ю. Коновалов. - Оренбург, 1993. - 180 с.
  5. Кочеровец В. И. Синдром избыточной колонизации тонкой кишки / В. И. Кочеровец, С. И. Перегудов, М. Д. Ханевич // Антибиотики и химиотерапия. - 1992. - Т. 37, № 3. - С. 39-44.
  6. Мартынов, В. Л. Клинические проявления несостоятельности бауги-ниевой заслонки и ее хирургическая коррекция: автореф. дис. … канд. мед. наук / В. Л. Мартынов. - Н. Новгород, 1994. - 23 с.
  7. Третьяков А. А. Морфологическая характеристика микрохирургиче-ских билиодигестивных анастомозов / А. А. Третьяков // Морфология. - 1999. - Т. 116, № 5. - C. 53-56.
  8. Bommelaer, G. Epidemiologie des troubles fonctionnes intestinaux / G. Bommelaer [et al.] // Gastroenterol. Clin. Biol. - 1986. - Vol. 10. - P. 7-12.
  9. Erckenbrecht, J. Obstipation und Colon irritable: diagnostische und therapeutische Probleme und deren Bewaltigung / J. Erckenbrecht. - Freiburg, 1995. - 128 s.

Full text is published :
Tretyakov A.A., Kagan I.I., Savin D.V., Dronova O.V. et al. CORRECTION ILEOCECAL VALVE VARIANT IN ITS DISEASE OF MICROSURGICAL TECHNIQUES. Experimental and Clinical Gastroenterology Journal. 2017;140(04):79-82
Read & Download full text

1. Multidisciplinary Medical Center of the Central Bank of the Russian Federation (Moscow, Russian Federation)

Abstract:Introduction: Barrett’s esophagus (PB) was recognized as one of the most serious complications of gastroesophageal reflux disease, an obligate precancer with a high malignancy index: 20-30 %. The aim of the study was to analyze the literature data and the changed notions about Barrett’s esophagus. Materials and methods: the literature sources were selected using the TRIP Database information retrieval system for the UpToDate, DynaMed, PubMed databases. We selected 4 clinical guidelines and 4 systematic reviews and meta-analyzes, the analysis of which was presented in the article. Conclusion: It should be noted that up to the present time many people’s efforts are aimed at developing an «ideal» universal medical technology for diagnosis and treatment of patients with ambiguous diagnosis of Barrett’s esophagus.

• References total 24 ⇓ :: .
  1. Белоус Т. А. Пищевод Баррета: морфологические основы развития // Российский журнал гастроэнтерологии, гепатологии, колопроктологии. - № 5, 2002. - С. 63-66.
  2. Белова Г. В. Методологические аспекты диагностики, мониторинга и лечения пациентов с пищеводом Баррета.: Дис…докт.мед.наук // ФГУ «МНИОИ им. П. А. Герцена Росмедтехнологии» М,-2009. 240 с.
  3. Годжелло Э. А., Галлингер Ю. А. Пищевод Баррета, аденокарцинома пищевода и задачи современной гастроэнтерологии // Российский журнал гастроэнтерологии, гепатологии, колопроктологии. - № 6, 2001. - С 71-75.
  4. Годжелло Э. А. Пищевод Баррета: эндоскопическая диагностика, стратегия наблюдения и лечения // Российский жкрнал гастроэнтерологии, гепатологии, колопроктологии. - № 5, 2000.-С. 67-71.
  5. Ефремов Л. И., Комиссаренко И. А. Метаболический континум и полиморбидность в гериатрии // Экспериментальная и клиническая гастроэнтерология.-№ 6, 2014.-С 4-7.
  6. Емельянов С. И., Рождественская Т. Ю., Мешков М. В. Аргон-плазменная коагуляция в лечении больных с пищеводом Баррета // Эндоскопическая хирургия. - № 1, 2013. - С. 65-69.
  7. Зайратьянц О. В., Маев И. В., Смольянникова В.А и соавторы. Патологическая анатомия пищевода Баррета // Архив патологии. - № 3, 2011. - С. 21-26.
  8. Ивашкин В. Т., Маев И. В., Трухманов А. С. Пищевод Баррета //М: Издательство «Шико».-2011.-608с. - 624 с.
  9. Кардашева С. С., Коган Е.А, Ивашкин В.Т и соавторы. Развитие дисплазии и рака при эзофагите и пищеводе Баррета: клинико-морфологические параллели // Российский журнал гастроэнтерологии, гепатологии, колопроктологии. - № 3, 2006.-С 4-11.
  10. Кардашева С. С., Трухманов А. С. Клиническая картина, факторы риска и иммуногистохимические маркеры при пищеводе Баррета // Российский журнал гастроэнтерологии, гепатологии, колопроктологии.-№ 3, 2008. - С 17-24.
  11. Кирова М. В. Оптимизация методов диагностики и лечения пищевода Баррета: Дис…канд.мед.наук / ГБОУВПО «Первый Московский государственный медицинский университет им. И. М. Сеченова-М,2014,143с.
  12. Кашин С. В., Иваников И. О. Пищевод Баррета: принципы эндоскопической диагностики и медикаментозной терапии // Российский журнал гастроэнтерологии, гепатологии, колопроктологии. - № 6, 2006.-С 73-77.
  13. Лазебник Л. В., Машарова А. А., Бордин Д. С. и др. Многоцентровое исследование «Эпидемиология Гастроэзофагеальной рефлюксной болезни в России (МЭГРЕ): первые итоги». Эксперим. и клин. гастроэнтерология. 2009; 6:4-12
  14. Мешков М. В., Алишихов Ш. А., Богданов Т. А. и соавторы. Пищевод Баррета: диагностические аспекты //Эндоскопическая хирургия. - № 6, 2012. - стр 32-34.
  15. Мясников А. Л. Русские терапевтические школы. - М., 1951
  16. Пирогов С. С., Карселадзе А. И. Молекулярно-генетические исследования в диагностике и оценке неопластической прогрессии пищевода Баррета // Сибирский онкологический журнал. - № 1, 2008. - стр 85-94.
  17. Руководство Общества американских гастроэнтерологов и эндоскопических хирургов по хирургическому лечению ГЭРБ, 2010.
  18. Старостин Б. Д. Пищевод Баррета: выявление, мониторинг, лечение // Российский журнал гастроэнтерологии, гепатологии, колопроктолгии. - № 3, 2003.С 84-90.
  19. «Пищевод Баррета» Клинические рекомендации, 2014, Москва,
  20. Fock K. M., Poh С. П. Gastroesophageal reflux disease. Gastroenterol 2010; 45 (8): 808-15.
  21. Maev I. V., Andreev D. N., Dichev, D. T. Gastroesophageal reflux disease: from pathogenesis to therapeutic aspects // Consilium medicum. 2013. Volume 15. No. 8. P. 30-34.]
  22. Richter J. E., Friedenberg F. K. Gastroesophageal reflux disease. In: Feldman M., Friedman I. S., Brandt I., eds. Sleisenger & Fordtran’s Gastrointestinal and liver Disease. 9th ed. Philadelphia, Pa: Saunders Elsevier; 2010; chap 43.
  23. Wu G. D., et al., 1993, Haggitt R. C., 1994, Cameron A. J. et al., 1995, 2000, 2003
  24. van Dekken H1, Hop WC, Tilanus HW, Haringsma J, van der Valk H, Wink JC, Vissers KJ. Am J Clin Pathol. 2008 Nov;130(5):745-53. Immunohistochemical evaluation of a panel of tumor cell markers during malignant progression in Barrett esophagus.

Full text is published :
Belova G.V., Rudenko O.S. BARRETT’S ESOPHAGUS: 20 YEARS LATER (MODERN VIEW OF THE PROBLEM). Experimental and Clinical Gastroenterology Journal. 2017;140(04):83-91
Read & Download full text

1. First Saint Petersburg I. P. Pavlov State Medical University (St. Petersburg, Russian Federation)

Keywords:hiatal hernia,diagnosis of hiatal hernia,surgical treatment of hiatal hernia

Abstract:Hiatal hernia is one of the most common variants of anatomical dislocation of the abdominal cavity elements. The diagnosis of this condition is based on the results of endoscopic and radiologic investigations. Indications for surgical treatment of hiatal hernias are resistance of gastroesophageal reflux symptoms for conservative management and the risk of its infringement. To increase the effectiveness of surgical interventions, prosthetic materials are used to correct of hiatal hole. The type of antireflux reconstruction depends on the gastroesophageal reflux severity and esophageal motility. Good long-term results of surgical treatment of hiatal hernias are found in 75-85 % of cases.

• References total 12 ⇓ :: .
  1. Кубышкин В., Корняк Б. Гастроэзофагеальная рефлюксная болезнь // M.: СПРОС, 1999. - 208 с.
  2. Пучков К., Филимонов В. Грыжи пищеводного отверстия диафрагмы // М.: Медпрактика, 2003. - 171 с.
  3. Granderath F., Kamolz T., Pointner R. Gastroesophageal reflux disease // Springer-Verlag. - Wien., 2006. - 320 p.
  4. Василевский Д., Кулагин В. Хирургическое лечение гастроэзофагеальной рефлюксной болезни (под ред. С. Ф. Багненко) // М.: СИМК, 2015. - 216 с.
  5. Broeders J. Laparoscopic antireflux surgery indications, techniques and physiological effects // Gildeprint Drukkerijen. - Netherlands., 2011. - 350 p.
  6. Katz P., Gerson L., Vela M. Guidelines for the diagnosis and management of gastroesophageal reflux disease // Am. J. Gastroenterol. - 2013. - Vol. 108. - P. 308-328.
  7. Kohn G., Price R., DeMeester S., et al. Guidelines for the management of hiatal hernia // Surg. Endosc. - 2013. - P. 1-42.
  8. Stefanidis D., Hope W., Kohn G. et al. Guidelines for surgical treatment of gastroesophageal reflux disease // Surg. Endoscop. - 2010. - Vol. 24. - P. 2647-2669.
  9. Fei L., del Genio G., Rossetti G., et al. Hiatal hernia recurrence: surgical complication or disease? Electron microscope findings of the diaphragmatic pillars // J. Gastrointest. Surg. - 2009. - Vol. 13. - P. 459-464.
  10. Frantzides C., Carlson M., Loizides S. et al. Hiatal hernia repair with mesh: a survey of SAGES members // Surg. Endosc. - 2010. - Vol. 24. - P. 1017-1024.
  11. Granderath F., Granderath U., Pointner R. Laparoscopic revisional fundoplication with circular hiatal mesh prosthesis: the long-term results // W. J. Surg. - 2008. - Vol. 32. - P. 999-1007.
  12. Pointner R., Granderath F. Hiatus hernia and recurrence: the Achilles heel of antireflux surgery? // Chirurg. - 2008. - Vol. 79. - P. 974-981.

Full text is published :
Vasilevskiy D.I., Smirnov A.A. DIAGNOSIS AND TREATMENT OF HIATAL HERNIAS. Experimental and Clinical Gastroenterology Journal. 2017;140(04):92-94
Read & Download full text

1. Multidisciplinary clinical and diagnostic center “Avicenna” (Simferopol, Russian Federation)

Abstract:The aim was to study the quality of oral colon preparation for colonoscopy with an individual approach, comparing full volume 4 l of glycols with polyethylene glycols (PEG) of a reduced 2 l volume (MOVIPREP®) under conditions of risk factors for poor bowel preparation. Conclusion: MOVIPREP® has a one-step morning dosage regimen and may be the drug of choice for patients for whom preparation on the day of a colonoscopy is important. MOVIPREP® was noted by patients as more comfortable due to taste, smaller volume, fewer bowel movements, which allows reduction of the time interval between the end of preparation and the holding of a colonoscopy. Keywords: colonoscopy, preparation for colonoscopy, colorectal cancer screening, oral colon cleansers, low-fiber diet, MOVIPREP®, PEG 4 liters

• References total 55 ⇓ :: .
  1. Baxter NN, Goldwasser MA, Paszat LF, et al. Association of colonoscopy and death from colorectal cancer. Ann Intern Med 2009;150:1-8
  2. Rex DK, Johnson DA, Anderson JC, et al. American College of Gastroenterology guidelines for colorectal cancer screening 2008. Am J Gastroenterol 2009;104:739-50.
  3. Levin B, Lieberman DA, McFarland B, et al. Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology. Gastroenterology 2008;134:1570-95
  4. Lieberman DA, Weiss DG, Bond JH, et al. Use of colonoscopy to screen asymptomatic adults for colorectal cancer. Veterans Affairs Cooperative Study Group 380. N Engl J Med 2000;343:162-8.
  5. Imperiale T, Wagner D, Lin C, et al. Risk of advanced proximal neoplasms in asymptomatic adults according to the distal colorectal findings. N Engl J Med 2000;343:169-74.
  6. Kim DH, Lee SY, Choi KS, et al. The usefulness of colonoscopy as a screening test for detecting colorectal polyps. Hepatogastroenterology 2007;54:2240-2.
  7. Niv Y, Hazazi R, Levi Z, et al. Screening colonoscopy for colorectal cancer in asymptomatic people: a meta-analysis. Dig Dis Sci 2008;53: 3049-54.
  8. Emura F, Saito Y, Taniguchi M et al. Further validation of magnifying chromocolonoscopy for differentiating colorectal neoplastic polyps in a health screening center. J Gastroenterol Hepatol 2007; 22: 1722-1727
  9. S. E. Kudo, S. Tamura, T. Nakajima, H. O. Yamano, H. Kusaka, and H. Watanabe. “Diagnosis of colorectal tumorous lesions by magnifying endoscopy,” Gastrointestinal Endoscopy, vol. 44, no. 1, pp. 8-14, 1996.
  10. K. Togashi, F. Konishi, T. Ishizuka, T. Sato, S. Senba, and K. Kanazawa. “Efficacy of magnifying endoscopy in the differential diagnosis of neoplastic and non-neoplastic polyps of the large bowel,” Diseases of the Colon and Rectum, vol. 42, no. 12, pp. 1602-1608, 1999.
  11. Rex DK. Narrow-band imaging without optical magnification for histologic analysis of colorectal polyps. Gastroenterology 2009;136:1174-81
  12. Y. Sano, M. Kobayashi, Y. Hamamoto et al. “New diagnostic method based on color imaging using narrow band imaging (NBI) system for gastrointestinal tract,” Gastrointestinal Endoscopy, vol. 53, p. AB 125, 2001.
  13. K. Gono, K. Yamazaki, N. Doguchi et al. “Endoscopic observation of tissue by narrow-band illumination,” Optical Review, vol. 10, pp. 1-5, 2003.
  14. K. Gono, T. Obi, M. Yamaguchi et al. “Appearance of enhanced tissue features in narrow-band endoscopic imaging,” Journal of Biomedical Optics, vol. 9, no. 3, pp. 568-577, 2004.
  15. Kahi CJ, Anderson JC, Waxman I, et al. High-definition chromocolonoscopy vs. high-definition white light colonoscopy for average-risk colorectal cancer screening. Am J Gastroenterol 2010;105:1301-7.
  16. Pohl J, Schneider A, Vogell H, et al. Pancolonic chromoendoscopy with indigo carmine versus standard colonoscopy for detection of neoplastic lesions: a randomised two-centre trial. Gut 2011;60:485-90
  17. R. Kiesslich, M. Von Bergh, M. Hahn, G. Hermann, and M. Jung. “Chromoendoscopy with indigocarmine improves the detection of adenomatous and nonadenomatous lesions in the colon,” Endoscopy, vol. 33, no. 12, pp. 1001-1006, 2001.
  18. J. C. Brooker, B. P. Saunders, S. G. Shah et al. “Total colonic dye-spray increases the detection of diminutive adenomas during routine colonoscopy: a randomized controlled trial,” Gastrointestinal Endoscopy, vol. 56, no. 3, pp. 333-338, 2002.
  19. H. Mitooka, T. Fujimori, S. Maeda, and K. Nagasako. “Minute flat depressed neoplastic lesions of the colon detected by contrast chromoscopy using an indigo carmine capsule,” Gastrointestinal Endoscopy, vol. 41, no. 5, pp. 453-459, 1995.
  20. K. I. Fu, Y. Sano, S. Kato et al. “Chromoendoscopy using indigo carmine dye spraying with magnifying observation is the most reliable method for differential diagnosis between non-neoplastic and neoplastic colorectal lesions: a prospective study,” Endoscopy, vol. 36, no. 12, pp. 1089-1093, 2004.
  21. Y. Sano, H. Ikematsu, K. I. Fu et al. “Meshed capillary vessels by use of narrow-band imaging for differential diagnosis of small colorectal polyps,” Gastrointestinal Endoscopy, vol. 69, no. 2, pp. 278-283, 2009.
  22. T. Uraoka, Y. Saito, H. Ikematsu, K. Yamamoto, and Y. Sano. “Sano’s capillary pattern classification for narrow-band imaging of early colorectal lesions,” Digestive Endoscopy, vol. 23, supplement 1, pp. 112-115, 2011.
  23. Hassan C, Pickhardt PJ, Rex DK. A resect and discard strategy would improve cost-effectiveness of colorectal cancer screening. Clin Gastroenterol Hepatol 2010; 8: 865-869
  24. Rex DK, Petrini JL, Baron TH, et al. Quality indicators for colonoscopy. Am J Gastroenterol 2006;101: 873-85.
  25. Corley DA, Jensen CD, Marks AR. Can we improve adenoma detection rates? A systematic review of intervention studies. Gastrointest Endosc 2011;74:656-65
  26. Corley D, Jensen CD, Marks AR, et al. Adenoma detection rate and risk of colorectal cancer and death. N Engl J Med 2014;370: 1298-306.
  27. Francis DL, Rodriguez-Correa DT, Buchner A, et al. Application of a conversion factor to estimate the adenoma detection rate from the polyp detection rate. Gastrointest Endosc 2011; 73: 493-7
  28. Rex DK. Colonoscopic withdrawal technique is associated with adenoma miss rates. Gastrointest Endosc 2000; 51: 33-6.
  29. Lee RH, Tang RS, Muthusamy VR, et al. Quality of colonoscopy withdrawal technique and variability in adenoma detection rates (with videos). Gastrointest Endosc 2011; 74: 128-34.
  30. Barclay R, Vicari JJ, Johanson JF, et al. Variation in adenoma detection rates and colonoscopic withdrawal times during screening colonoscopy [abstract]. Gastrointest Endosc 2005;61: AB 107
  31. Barclay RL, Vicari JJ, Doughty AS, et al. Colonoscopic withdrawal times and adenoma detection during screening colonoscopy. N Engl J Med 2006; 355: 2533-41.
  32. Barclay RL, Vicari JJ, Greenlaw RL. Effect of a time-dependent colonoscopic withdrawal protocol on adenoma detection during screening colonoscopy. Clin Gastroenterol Hepatol 2008; 6: 1091-8.
  33. Rex DK. Still photography versus videotaping for documentation of cecal intubation: a prospective study. Gastrointest Endosc 2000; 51: 451-9.
  34. Rex DK, Hewett DG, Raghavendra M, et al. The impact of videorecording on the quality of colonoscopy performance: a pilot study. Am J Gastroenterol 2010;105: 2312-7.
  35. Farrar W, Sawhney M, Nelson D et al. Colorectal cancers found after a complete colonoscopy. Clin Gastroenterol Hepatol 2006; 4: 1259-1264
  36. Robertson DJ, Greenberg ER, Beach M et al. Colorectal cancer in patients under close colonoscopic surveillance. Gastroenterology 2005; 129: 34-41
  37. Sawhney MS, Farrar WD, Gudiseva S et al. Microsatellite instability in interval colon cancers. Gastroenterology 2006; 131: 1700-1705
  38. Bressler B, Paszat L, Chen Z et al. Rates of new or missed colorectal cancers after colonoscopy and their risk. Gastroenterology 2007; 132: 96-102
  39. Singh H, Turner D, Xue L et al. Risk of developing colorectal cancer following a negative colonoscopy examination. JAMA 2006; 295: 2366-2373
  40. Brenner H, Chang-Claude J, Seiler CM, et al. Does a negative screening colonoscopy ever need to be repeated? Gut 2006;55: 1145-50.
  41. Lakoff J, Paszat LF, Saskin R, et al. Risk of developing proximal versus distal colorectal cancer after a negative colonoscopy: a populationbased study. Clin Gastroenterol Hepatol 2008;6: 1117-21.
  42. Singh H, Nugent Z, Mahmud SM, et al. Predictors of colorectal cancer after negative colonoscopy: a population-based study. Am J Gastroenterol 2010;105: 663-73.
  43. Thomas-Gibson S, Rogers P, Cooper S et al. Judgement of the quality of bowel preparation at screening flexible sigmoidoscopy is associated with variability in adenoma detection rates. Endoscopy 2006; 38: 456-460
  44. Harewood GC, Sharma VK, de Garmo P. Impact of colonoscopy preparation quality on detection of suspected colonic neoplasia. Gastrointest Endosc 2003; 58: 76-79
  45. Froehlich F, Wietlisbach V, Gonvers JJ et al. Impact of colonic cleansing on quality and diagnostic yield of colonoscopy: the European Panel of Appropriateness of Gastrointestinal Endoscopy European multicenter study. Gastrointest Endosc 2005; 61: 378-384
  46. Singh H, Nugent Z, Demers AA, et al. The reduction in colorectal cancer mortality after colonoscopy varies by site of the cancer. Gastroenterology 2010;139: 1128-37.
  47. Brenner H, Chang-Claude J, Seiler CM, et al. Protection from colorectal cancer after colonoscopy: a population-based, case-control study. Ann Intern Med 2011;154: 22-30.
  48. Burke CA, Church JM. Enhancing the quality of colonoscopy: the importance of bowel purgatives. Gastrointest Endosc 2007; 66: 565-573
  49. Wexner SD, Beck DE, Baron TH, et al. A consensus document on bowel preparation before colonoscopy: prepared by a Task Force from the American Society of Colon and Rectal Surgeons (ASCRS), the American Society for Gastrointestinal Endoscopy (ASGE), and the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES). Surg Endosc 2006;20: 1161.
  50. Larsen M, Hills N, Terdiman J. The impact of the quality of colon preparation on follow-up colonoscopy recommendations. Am J Gastroenterol 2011;106: 2058-62.
  51. Hassan C et al. Bowel preparation for colonoscopy: ESGE Guideline… Endoscopy 2013; 45: 142-150
  52. Bowel preparation before colonoscopy Gastrointest Endosc 2015;81:781-794 / DOI: http://dx.doi.org/10.1016/j.gie.2014.09.04
  53. Brenner H, Chang-Claude J, Seiler CM, et al. Does a negative screening colonoscopy ever need to be repeated? Gut 2006;55: 1145-50.
  54. Calderwood AH, Jacobson BC. Comprehensive validation of the Boston Bowel Preparation Scale. Gastrointest Endosc 2010;72: 686-92.
  55. B. Rembacken, C. Hassan, J. F. Riemann, A. Chilton, M. Rutter, J.-M. Dumonceau, M. Omar, T. Ponchon. Quality in screening colonoscopy: position statement of the European Society of Gastrointestinal Endoscopy (ESGE). Endoscopy 2012; 44: 957-968

Full text is published :
Korneev A.A. PREPARING FOR A COLONOSCOPY. CRIMEAN EXPERIENCE. Experimental and Clinical Gastroenterology Journal. 2017;140(04):95-102
Read & Download full text

1. Moscow state medical and dentistry University n.a. A.I. Evdokimov (Moscow, Russian Federation)

Keywords:Helicobacter pylori, eradication therapy, resistance

Abstract:In accordance with modern consensus recommendations, the choice of eradication therapy (ET) should be based on information about the prevalence of resistant H. pylori strains to clarithromycin and metronidozole (including dual resistance to these drugs) in a particular region of the world. In regions with a low level of clarithromycin resistance (<15%), classical triple therapy is considered as first-line therapy and can be administered empirically. Bismuth-containing quadrotherapy is an alternative. In regions with high resistance to clarithromycin (> 15%), bismuth-containing quadrotherapy or quadrotherapy without bismuth preparations (“simultaneous” therapy) is recommended. In regions with a high double resistance rate, both clarithromycin and metronidazole, bismuth-containing quadrotherapy is recommended as first-line ET. Among the optimization methods that can significantly increase the effectiveness of ET can be distinguished: the addition of bismuth drug in the ET regimen (by 10–20%), the use of rebathide in the ET regimen (by 11.9%), the use of adjuvant therapy using probiotics 8.1–14.1%) and the use of double doses of proton pump inhibitors (by 8%), as well as an increase in patient compliance, timely monitoring of the effectiveness of therapy and the use of adequate doses of drugs with proven effectiveness. Significant reduction in the frequency of adverse events against the background of ongoing ET is achieved only using adjuvant therapy with probiotics.

• References total 73 ⇓ :: .
  1. Маев И. В., Самсонов А. А., Андреев Д. Н. Инфекция Helicobacter pylori. М.: ГЭОТАР-Медиа; 2016.
  2. Morgan D.R, Crowe S. E. Helicobacter pylori infection. In.: Sleisenger and Fordtran’s Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management / edited by Mark Feldman, Lawrence S Friedman, Laurence J Brandt. - 10th ed. 2015.
  3. Malfertheiner P, Megraud F, O’Morain CA, Gisbert JP, Kuipers EJ, Axon AT, Bazzoli F, Gasbarrini A, Atherton J, Graham DY, Hunt R, Moayyedi P, Rokkas T, Rugge M, Selgrad M, Suerbaum S, Sugano K, El-Omar EM. Management of Helicobacter pylori infection-the Maastricht V/Florence Consensus Report. Gut. 2017; 66(1):6-30
  4. Маев И. В., Андреев Д. Н., Кучерявый Ю. А. Инфекция Helicobacter pylori и экстрагастродуоденальные заболевания. Терапевтический архив. 2015; 8: 103-110.
  5. Kyburz A, Müller A. Helicobacter pylori and Extragastric Diseases. Curr Top Microbiol Immunol. 2017;400:325-347.
  6. Sugano K, Tack J, Kuipers EJ, Graham DY, El-Omar EM, Miura S, Haruma K, Asaka M, Uemura N, Malfertheiner P; faculty members of Kyoto Global Consensus Conference. Kyoto global consensus report on Helicobacter pylori gastritis. Gut. 2015; 64(9):1353-67.
  7. Fallone CA, Chiba N, van Zanten SV, Fischbach L, Gisbert JP, Hunt RH, Jones NL, Render C, Leontiadis GI, Moayyedi P, Marshall JK. The Toronto Consensus for the Treatment of Helicobacter pylori Infection in Adults. Gastroenterology. 2016;151(1):51-69.e14
  8. Chey WD, Leontiadis GI, Howden CW, Moss SF. ACG Clinical Guideline: Treatment of Helicobacter pylori Infection. Am J Gastroenterol. 2017;112(2):212-239.
  9. Malfertheiner P, Link A, Selgrad M. Helicobacter pylori: perspectives and time trends. Nat Rev Gastroenterol Hepatol. 2014;11(10):628-38.
  10. Graham DY, Lee YC, Wu MS. Rational Helicobacter pylori therapy: evidence-based medicine rather than medicine-based evidence. Clin Gastroenterol Hepatol 2014;12:177-86.
  11. Feng L, Wen MY, Zhu YJ, Men RT, Yang L. Sequential Therapy or Standard Triple Therapy for Helicobacter pylori Infection: An Updated Systematic Review. Am J Ther. 2016;23(3): e880-93.
  12. Venerito M, Krieger T, Ecker T, Leandro G, Malfertheiner P. Meta-analysis of bismuth quadruple therapy versus clarithromycin triple therapy for empiric primary treatment of Helicobacter pylori infection. Digestion. 2013;88(1):33-45.
  13. Puig I, Baylina M, Sánchez-Delgado J, et al. Systematic review and meta-analysis: triple therapy combining a proton-pump inhibitor, amoxicillin and metronidazole for Helicobacter pylori first-line treatment. J Antimicrob Chemother. 2016;71(10):2740-53.
  14. Li BZ, Threapleton DE, Wang JY, et al. Comparative effectiveness and tolerance of treatments for Helicobacter pylori: systematic review and network meta-analysis. BMJ. 2015;351: h4052.
  15. Lee JY, Park KS. Optimal First-Line Treatment for Helicobacter pylori Infection: Recent Strategies. Gastroenterol Res Pract. 2016;2016:9086581.
  16. Luther J, Higgins PD, Schoenfeld PS, Moayyedi P, Vakil N, Chey WD. Empiric quadruple vs. triple therapy for primary treatment of Helicobacter pylori infection: Systematic review and meta-analysis of efficacy and tolerability. Am J Gastroenterol. 2010;105(1):65-73.
  17. Ermis F, Senocak Tasci E. Current Helicobacter pylori treatment in 2014. World J Methodol. 2015;5(2):101-7.
  18. Essa AS, Kramer JR, Graham DY, Treiber G. Meta-analysis: four-drug, three-antibiotic, non-bismuth-containing “concomitant therapy” versus triple therapy for Helicobacter pylori eradication. Helicobacter. 2009;14(2):109-18.
  19. Gisbert JP, Calvet X. Update on non-bismuth quadruple (concomitant) therapy for eradication of Helicobacter pylori. Clin Exp Gastroenterol. 2012;5:23-34.
  20. He L, Deng T, Luo H. Meta-analysis of sequential, concomitant and hybrid therapy for Helicobacter pylori eradication. Intern Med. 2015;54(7):703-10
  21. Самсонов А. А., Андреев Д. Н., Гречушников В. Б., Айвазова Р. А. Резистентность Helicobacter pylori к компонентам эрадикационной терапии и пути ее преодоления. Фарматека. 2015. 2. С. 26-30.
  22. Gisbert JP, Calvet X, O’Connor JP, Mégraud F, O’Morain CA. The sequential therapy regimen for Helicobacter pylori eradication. Expert Opin Pharmacother.2010;11:905-18.
  23. Vaira D, Zullo A, Hassan C, Fiorini G, Vakil N. Sequential therapy for Helicobacter pylori eradication: The time is now! Therap Adv Gastroenterol. 2009;2:317-22.
  24. Zullo A, De Francesco V, Hassan C, Morini S, Vaira D. The sequential therapy regimen for Helicobacter pylori eradication: A pooled-data analysis. Gut.2007;56:1353-7.
  25. Gatta L, Vakil N, Vaira D, Scarpignato C. Global eradication rates for Helicobacter pylori infection: systematic review and meta-analysis of sequential therapy. BMJ. 2013;347: f4587.
  26. Chen PY, Wu MS, Chen CY, et al. Systematic review with meta-analysis: the efficacy of levofloxacin triple therapy as the first- or second-line treatments of Helicobacter pylori infection. Aliment Pharmacol Ther. 2016;44(5):427-37.
  27. Юренев Г. Л., Андреев Д. Н., Парцваниа-Виноградова Е.В., Дичева Д. Т. Гибридная схема эрадикационной терапии инфекции Helicobacter pylori: систематизация литературных данных. Фарматека. 2017; 2: 71-74.
  28. Song ZQ, Liu J, Zhou LY. Hybrid Therapy Regimen for Helicobacter Pylori Eradication. Chin Med J (Engl). 2016;129(8):992-9.
  29. Hsu PI, Lin PC, Graham DY. Hybrid therapy for Helicobacter pylori infection: A systemic review and meta-analysis. World J Gastroenterol. 2015;21(45):12954-62.
  30. Song ZQ, Zhou LY. Hybrid, sequential and concomitant therapies for Helicobacter pylori eradication: A systematic review and meta-analysis. World J Gastroenterol. 2016;22(19):4766-75.
  31. Андреев Д. Н., Дичева Д. Т., Маев И. В. Возможности оптимизации эрадикационной терапии инфекции Helicobacter pylori в современной клинической практике. Терапевтический архив. 2017; 2: 76-83.
  32. Villoria A., Garcia P., Calvet X., Gisbert J. P., Vergara M. Meta-analysis: high-dose proton pump inhibitors vs. standard dose in triple therapy for Helicobacter pylori eradication // Aliment Pharmacol Ther. 2008; 28 (7): 868-877.
  33. McNicholl AG, Linares PM, Nyssen OP, Calvet X, Gisbert JP. Meta-analysis: esomeprazole or rabeprazole vs. first-generation pump inhibitors in the treatment of Helicobacter pylori infection. Aliment Pharmacol Ther. 2012; 36 (5): 414-425.
  34. Desta ZX, Shin JG, Flockhart DA. Clinical significance of the cytochrome P450 2C 19 genetic polymorphism. Clin. Pharmacokinet. 2002; 41(12): 913-958.
  35. Maev I. V., Andreev D. N., Kucheryavyi Yu.A., Dicheva D. T. Host factors influencing the eradication rate of Helicobacter pylori. World Applied Sci J. 2014; 30: 134-140.
  36. Li-Wan-Po A, Girard T, Farndon P, Cooley C, Lithgow J. Pharmacogenetics of CYP2C 19: functional and clinical implications of a new variant CYP2C 19*17. Br J Clin Pharmacol. 2010;69(3):222-30.
  37. Kuo CH, Lu CY, Shih HY, Liu CJ, Wu MC, Hu HM, Hsu WH, Yu FJ, Wu DC, Kuo FC. CYP2C 19 polymorphism influences Helicobacter pylori eradication. World J Gastroenterol. 2014;20(43):16029-36.
  38. Padol S, Yuan Y, Thabane M, Padol IT, Hunt RH. The effect of CYP2C 19 polymorphisms on H. pylori eradication rate in dual and triple first-line PPI therapies: a meta-analysis. Am J Gastroenterol. 2006;101(7):1467-75.
  39. Sakai T, Aoyama N, Kita T, Sakaeda T, Nishiguchi K, Nishitora Y, Hohda T, Sirasaka D, Tamura T, Tanigawara Y, Kasuga M, Okumura K. CYP2C 19 genotype and pharmacokinetics of three proton pump inhibitors in healthy subjects. Pharm Res. 2001;18(6):721-7.
  40. Gibbons TE, Gold BD. The use of proton pump inhibitors in children: a comprehensive review. Paediatr Drugs. 2003;5(1):25-40.
  41. Litalien C, Théorêt Y, Faure C. Pharmacokinetics of proton pump inhibitors in children. Clin Pharmacokinet. 2005;44(5):441-66.
  42. Tang HL, Li Y, Hu YF, Xie HG, Zhai SD. Effects of CYP2C 19 loss-of-function variants on the eradication of H. pylori infection in patients treated with proton pump inhibitor-based triple therapy regimens: a meta-analysis of randomized clinical trials. PLoS One 2013;8: e62162.
  43. Denisenko NP, Sychev DA, Sizova ZhM, Grachev AV, Velikolug KA. High frequency of CYP2C 19 ultrarapid metabolizers in Russian patients with peptic ulcer. Eksp Klin Gastroenterol. 2015;(6):11-5.
  44. Tsutsui N, Taneike I, Ohara T, Goshi S, Kojio S, Iwakura N, Matsumaru H, Wakisaka-Saito N, Zhang HM, Yamamoto T. A novel action of the proton pump inhibitor rabeprazole and its thioether derivative against the motility of Helicobacter pylori. Antimicrob Agents Chemother. 2000;44(11):3069-73.
  45. Ohara T, Goshi S, Taneike I, Tamura Y, Zhang HM, Yamamoto T. Inhibitory action of a novel proton pump inhibitor, rabeprazole, and its thioether derivative against the growth and motility of clarithromycin-resistant Helicobacter pylori. Helicobacter. 2001;6(2):125-9.
  46. Zhang Z, Liu ZQ, Zheng PY, Tang FA, Yang PC. Influence of efflux pump inhibitors on the multidrug resistance of Helicobacter pylori. World J Gastroenterol. 2010;16(10):1279-84.
  47. Sugimoto M, Sahara S, Ichikawa H, Kagami T, Ban H, Otsuka T, Andoh A, Furuta T. Four-times-daily Dosing of Rabeprazole with Sitafloxacin, High-Dose Amoxicillin, or Both for Metronidazole-Resistant Infection with Helicobacter pylori in Japan. Helicobacter. 2017;22(1). e12319.
  48. Маев И. В., Андреев Д. Н., Дичева Д. Т. Гастропатии, индуцированные нестероидными противовоспалительными средствами: патогенетически обоснованные подходы к профилактике и терапии. Фарматека. 2016; 2: 49-54.
  49. Huang JQ, Sridhar S, Hunt RH. Role of Helicobacter pylori infection and non-steroidal anti-inflammatory drugs in peptic-ulcer disease: a meta-analysis. Lancet. 2002;359(9300):14-22.
  50. Niv Y. Helicobacter pylori and gastric mucin expression: A systematic review and meta-analysis. World J Gastroenterol. 2015;21(31):9430-6.
  51. Ивашкин В. Т., Маев И. В., Ивашкин К. В., Корочанская Н. В., Лопина О. Д., Лапина Т. Л., Полуэктова Е. А., Румянцева Д. Е., Симаненков В. И., Трухманов А. С., Хлынов И. Б., Шептулин А. А. Роль нарушения защитных факторов в развитии кислотозависимых заболеваний. (Резолюция Экспертного совета 12-13 марта 2016). Рос. журн. гастроэнтерол. гепатол. колопроктол. 2016; 26(3):115-116.
  52. Skoczylas T, Sarosiek I, Sostarich S, McElhinney C, Durham S, Sarosiek J. Significant enhancement of gastric mucin content after rabeprazole administration: its potential clinical significance in acid-related disorders. Dig Dis Sci. 2003;48(2):322-8.
  53. Sarosiek I, Olyaee M, Majewski M, Sidorenko E, Roeser K, Sostarich S, Wallner G, Sarosiek J. Significant increase of esophageal mucin secretion in patients with reflux esophagitis after healing with rabeprazole: its esophagoprotective potential. Dig Dis Sci. 2009;54(10):2137-42.
  54. Ge R., Chen Z., Zhou Q. The actions of bismuth in the treatment of Helicobacter pylori infections: an update. Metallomics. 2012; 4 (3): 239-243.
  55. Alkim H, Koksal AR, Boga S, Sen I, Alkim C. Role of Bismuth in the Eradication of Helicobacter pylori. Am J Ther. 2016 Jan 21. [Epub ahead of print].
  56. Dore MP, Lu H, Graham DY. Role of bismuth in improving Helicobacter pylori eradication with triple therapy. Gut. 2016;65(5):870-8.
  57. Liao J, Zheng Q, Liang X, Zhang W, Sun Q, Liu W, Xiao S, Graham DY, Lu H. Effect of fluoroquinolone resistance on 14-day levofloxacin triple and triple plus bismuth quadruple therapy. Helicobacter 2013;18:373-7.
  58. Cao Z, Chen Q, Zhang W, Liang X, Liao J, Liu W, Xiao S, Lu H. Fourteen-day optimized levofloxacin-based therapy versus classical quadruple therapy for Helicobacter pylori treatment failures: a randomized clinical trial. Scand J Gastroenterol. 2015;50(10):1185-90.
  59. Маев И. В., Самсонов А. А., Коровина Т. И. Гречушников В. Б., Андреев Н. Г. Висмута трикалия дицитрат повышает эффективность антихеликобактерной терапии первой линии. Эксперимент. и клин. гастроэнтерол. 2012; 8: 92-97.
  60. Бордин Д. С., Машарова А. А., Хомерики С. Г. Хронический гастрит: современный взгляд на старую проблему. Эксперимент. и клин. гастроэнтерол. 2012; 5: 99-106.
  61. Nishizawa T, Nishizawa Y, Yahagi N, Kanai T, Takahashi M, Suzuki H. Effect of supplementation with rebamipide for Helicobacter pylori eradication therapy: a systematic review and meta-analysis. J Gastroenterol Hepatol. 2014;29 Suppl 4:20-4.
  62. Zou J., Dong J., Yu X. Meta-analysis: Lactobacillus containing quadruple therapy versus standard triple first-line therapy for Helicobacter pylori eradication. Helicobacter. 2009; 14 (5): 97-107.
  63. Szajewska H., Horvath A., Piwowarczyk A. Meta-analysis: the effects of Saccharomyces boulardii supplementation on Helicobacter pylori eradication rates and side effects during treatment. Aliment Pharmacol Ther. 2010; 32 (9): 1069-1079.
  64. Wang Z. H., Gao Q. Y., Fang J. Y. Meta-Analysis of the Efficacy and safety of Lactobacillus-containing and Bifidobacterium-containing probiotic compound preparation in Helicobacter pylori eradication therapy. J Clin Gastroenterol. 2013; 47 (1): 25-32.
  65. Lv Z, Wang B, Zhou X, Wang F, Xie Y, Zheng H, Lv N. Efficacy and safety of probiotics as adjuvant agents for Helicobacter pylori infection: A meta-analysis. Exp Ther Med. 2015; 9(3):707-716.
  66. Lau CS, Ward A, Chamberlain RS. Probiotics improve the efficacy of standard triple therapy in the eradication of Helicobacter pylori: a meta-analysis. Infect Drug Resist. 2016;9:275-289.
  67. Ивашкин В.Т, Лапина Т.Л, Страчунский Л. С., Захарова Н.В, Николаева Н. Н., Ткачев А. В., Симаненков В. И., Абдулхаков Р. А., Осипенко М. Ф., Дехнич Н. Н. Ведение больных язвенной болезнью в амбулаторно-поликлинических условиях: результаты многоцентрового российского фармакоэпидемиологического исследования. Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2005.6; 16-21.
  68. Маев И. В., Кучерявый Ю. А., Андреев Д. Н. Причины неэффективности антигеликобактерной терапии. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2013; 6: 62-72.
  69. Tschabitscher D., Platzer P., Baumgärtel C., Müllner M. Generic drugs: quality, efficacy, safety and interchangeability. Wien. Klin. Wochenschr. 2008; 120 (3-4): 63-69.
  70. Nightingale CH. A survey of the quality of generic clarithromycin products from 18 countries. Clin Drug Investig. 2005;25(2):135-52.
  71. Cammarota S, Bruzzese D, Sarnelli G, Citarella A, Menditto E, Riegler S, Savino IG, Vozzella L, Piccinocchi G, Napoli L, Arpino G, Cuomo R. Proton pump inhibitors prescribing following the introduction of generic drugs. Eur. J. Clin. Invest. 2012; 42(10): 1068-1078.
  72. Передерий В. Г., Чернявский В. В. Медико-экономическая эффективность различных схем лечения Нр-позитивных дуоденальных язв. Сучасна гастроентерол. 2004; 3(17):72-76.
  73. Самсонов А. А., Гречушников В. Б., Андреев Д. Н., Юренев Г. Л., Лежнева Ю. А., Маев И. В. Оценка фармакоэкономических показателей лечения пациентов с заболеваниями, ассоциированными с Helicobacter pylori. Тер архив. 2014;86(8):56-61.

Full text is published :
Maev I.V., Andreev D.N., Samsonov A.A., Valiev A.M. MODERN SCHEMES OF ERADICATION THERAPY OF INFECTION HELICOBACTER PYLORI: STRATEGY OF DIFFERENTIATED APPLICATION, EFFICIENCY AND SAFETY. Experimental and Clinical Gastroenterology Journal. 2017;140(04):103-110
Read & Download full text

1. First Moscow State Medical Univercity (Moscow, Russian Federation)
2. Pirogov Russian National Research Medical University (Moscow, Russian Federation)
3. FSAI The Scientific Center of Children’s Health (Moscow, Russian Federation)
4. Morozov Pediatric Clinical Hospital of Moscow Healthcare Department (Moscow, Russian Federation)
5. Moscow Clinical and Research Center (Moscow, Russian Federation)
6. Children’s Clinical and Research Institute of Emergency surgery and Trauma (Moscow, Russian Federation)

Keywords:children,confocal laser endomicroscopy,optical biopsy,histology,gastric,duodenum

Abstract:Aim: to analyze the value of confocal laser endomicroscopy in diagnostics of gastric and duodenal mucosa changes in children. Patients and Methods: In the current study a total of 116 children aged from 3 to 18 years old undergo conventional endoscopy with confocal laser endomicroscopy supplemented with mucosal biopsy followed by traditional histology in the period from 2011 until 2014. To determine the prognostic value of the of probe based CLE in the evaluation of normal and pathological changes of the gastric and duodenal mucosa a comparison of results of optical biopsy with the data obtained during the standard histological examination were performed. Results: After results of probe-based CLE and traditional histology were comprised optical biopsy showed 83,7 %sensitivity and 87,5 %specificity to gastritis with Spearmen correlation 0,67 (р=0,001); 86,7 % sensitivity and 81,8 %specificity to duodenitis with Spearmen correlation 0,67(р=0,001). Conclusion: Confocal endomicroscopy may become one of the leading methods in pediatric gastroenterology since it allows the endoscopists to inspect the mucosa at the cellular level during the endoscopic procedure and can help to eliminate the mismatch between histological and endoscopic diagnosis.

• References total 12 ⇓ :: .
  1. Бельмер С. В., Разумовский А. Ю., Хавкин А. И. (ред.). Болезни желудка и двенадцатиперстной кишки у детей - М.: ИД-МЕДПРАКТИКА-М, 2017, 536 с.
  2. Лазебник Л. Б., Щербаков П. Л. Гастроэнтерология. М.: Издание медицинских книг, 2011. -357с.
  3. Sheiko M. A., Feinstein J. A., Capocelli K. E., Kramer R. E. Diagnostic yield of EGD in children: a retrospective single-center study of 1000 cases.Gastrointestinal Endoscopy. 2013; Vol. 78(1), p. 47-54.
  4. Шавров А. А., Харитонова А. Ю., Шавров А. А., Морозов Д. А. Современные методы эндоскопической диагностики и лечения болезней верхнего отдела пищеварительного тракта у детей.Вопросы современной педиатрии. 2015. Т. 14. № 4. С. 497-502.
  5. Wallace M., Lauwers G. Y., Chen Y. Miami classification for probe-based confocal laser endomicroscopy. Endoscopy. 2011; 43(10):882-891.
  6. Dixon M. F., Genta R. M., Yardley J. H., Correa P. Classification and grading of gastritis. The updated Sydney System. Am. J. Surg. Pathol. 1996; 20:1161-1181.
  7. Gershman G., Thomson M. Practical Pediatric Gastrointestinal endoscopy, Second edition. Wiley-Blackwell; 2012. p. 256.
  8. Шавров (мл.) А.А., Шавров А. А., Харитонова А. Ю., Морозов Д. А., Талалаев А. Г., Гайдаенко А. Е., Калашникова Н. А. Конфокальная лазерная эндомикроскопия: история развития, проблемы и перспективы у детей. Вестник РАМН. 2014;11-12:60-66.
  9. Шавров (мл.) А.А., Волынец Г. В., Шавров А. А., Хавкин А. И., Талалаев А. Г., Хомерики С. Г., Харитонова А. Ю. Оптическая биопсия в диагностике изменений слизистой оболочки пищевода у детей. Экспериментальная и клиническая гастроэнтерология. 2015; 122 (10): 7-12.
  10. Greenson J., Polydorides A. D., Montgomery E. A., Lauwers G., Purdy J., Lamps L. Diagnostic Pathology: Gastrointestinal. Amirsys; 2009. p.800.
  11. Carr N. J., Leadbetter H., Marriott A. Correlation between the endoscopic and histologic diagnosis of gastritis. Ann. Diagn. Pathol. 2012; Vol. 16, p. 13-15.
  12. Oderda G, Forni M, Farina L, et al. Duodenitis in children: clinical, endoscopic, and pathological aspects. Gastrointestinal Endoscopy 1987; Vol. 33, p. 366-369.

Full text is published :
Shavrov A.A., Volynets G.V., Khavkin A.I., Morozov D.A. et al. CONFOCAL LASER ENDOMICROSCOPY FOR DIAGNOSIS OF GASTRIC AND DUODENAL MUCOSAL CHANGES IN CHILDREN. Experimental and Clinical Gastroenterology Journal. 2017;140(04):111-116
Read & Download full text

1. Herzen Moscow Cancer Research Institute, branch of National Medical Research Radiology Center (St. Petersburg, Russian Federation)

Abstract:Introduction Plexiform fibromyxoma (PFM) is a very rare gastric tumor, no more than 20 cases described in literature. PFM is a benign mesenchymal tumor, usually occurs in gastric antrum. PFM in pathology reports characterized as mixed-type tumor located in submucosal and mucosal layer of gastric wall., consists of smooth-muscle cells, located between plexiform stromal webs, positive for SMA and negative for CD 117, CD 34 and S-100 Objectives The main aims of presented clinical case is to identify typical endoscopic diagnostic sings of PFM and to evaluate possibilities of endoscopic treatment in such cases. Methods In 2016 in P. A. Herzen Cancer Research Institute one case of PFM was detected in asymptomatic 35 y. o. female patient. Multimodal endoscopic examination, consisted of white-light high definition (WLI-HD) endoscopy, narrow-band imaging with near focus (NBI-NF) and endoscopic ultrasonography (EUS) with 20MHz miniprobe, was performed for diagnostic purposes. For treatment of identified tumor endoscopic submucosal dissection (ESD) was implemented. Results Multimodal endoscopic examination data showed, that PFM characterized as ulcerated polypoid submucosal lesion in gastric antrum. Gastric pits in ulceration margins, clearly visible with NB-NF, are elongated, but not distorted, intrapapillary capillary loops are broadened, but regular-shaped. EUS showed moderate-hypoechoic tumor mass in mucosa and 1/3 of submucosa, not invading muscularis propria. On the basis of the diagnostic data results, gastric PFM was suspected. Since lesion characterized with superficial invasion, ESD was performed, tumor resected en bloc. Pathology and immunohistochemical examination of retrieved specimen confirmed PFM diagnosis. Conclusion Gastric plexiform fibromyxoma has a specific endoscopic and endosonographic features, helpful for differential diagnostics. If tumor invading only mucosa and submucosal layer of gastric wall, it is safe to perform ESD as a treatment choice.

• References total 8 ⇓ :: .
  1. Inoue Y. [и др.]. Laparoscopy endoscopy cooperative surgery for gastric plexiform fibromyxoma: a case report // Surgical Case Reports. 2016. № 1 (2).
  2. Kane J. [и др.]. Plexiform fibromyxoma with cotyledon-like serosal growth: A case report of a rare gastric tumor and review of the literature // Oncology Letters. 2016.
  3. Kim A. [и др.]. Plexiform Angiomyxoid Myofibroblastic Tumor of the Stomach: A Case Report // Journal of Korean Medical Science. 2011. № 11 (26). C. 1508.
  4. Li P. [и др.]. Case Report Presence of smooth muscle cell differentiation in plexiform angiomyxoid myofibroblastic tumor of the stomach: a case report // Int J Clin Exp Pathol. 2014. № 2 (7). C. 823-827.
  5. Miettinen M. [и др.]. Plexiform Fibromyxoma: A Distinctive Benign Gastric Antral Neoplasm Not to be Confused With a Myxoid GIST // The American Journal of Surgical Pathology. 2009. № 11 (33). C. 1624-1632.
  6. Sakamoto K. [и др.]. A case of gastric plexiform fibromyxoma: radiological and pathological findings // Japanese Journal of Radiology. 2014. № 7 (32). C. 431-436.
  7. Sing Y. [и др.]. Gastric plexiform angiomyxoid myofibroblastic tumor: Gastric plexiform angiomyxoid tumor // Pathology International. 2010. № 9 (60). C. 621-625.
  8. Takahashi Y. Plexiform angiomyxoid myofibroblastic tumor of the stomach // World Journal of Gastroenterology. 2010. № 23 (16). C. 2835.

Full text is published :
Pirogov S.S., Sokolov V.V., Kaprin A.D., Volchenko N.N. et al. ENDOSCOPIC DIAGNOSTICS AND TREATMENT OF GASTRIC PLEXIFORM FIBROMYXOMA. Experimental and Clinical Gastroenterology Journal. 2017;140(04):117-120
Read & Download full text

1. National medical surgical center n. a.. N. I. Pirogov (Moscow, Russian Federation)

Abstract: In memory of Andrei Valentinovich Filin, head of the endoscopy department of the Leningrad Regional Clinical Hospital, chief specialist in endoscopy of the Leningrad Region, one of the most respected endoscopists in Russia. The article is in Russian.

Full text is published :
Solonitsyn E.G. MEMORY OF ANDREY VALENTINOVICH FILIN. Experimental and Clinical Gastroenterology Journal. 2017;140(04):121-122
Read & Download full text