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CLINICAL GASTROENTEROLOGY

    1. Tver State Medical University (Tver, Russian Federation)

    Keywords:microflora of the digestive tract,gastroesophageal reflux disease,duodenogastroesophageal reflux

    Abstract: Aim. The study of the qualitative and quantitative characteristics of microbiocenosis of the oral cavity and esophagogastroduodenal zone in patients with gastroesophageal reflux disease (GERD), associated with duodenogastroesophageal reflux (DGER) as a manifestation of biliary pathology. Materials and methods. In 83 GERD patients with symptoms of reflux esophagitis and DGER we studied the microbial landscape of the oral fluid and biopsy samples from visually unaltered sections of the mucosa of the lower third of the esophagus, antrum and duodenum by the classical bacteriological methods. Results. Biopsy specimens from the esophagogastroduodenal zone mucosa in patients with GERD indicated high content of staphylococci (92 %) and streptococci (85 %) in amount of from 4,8 to 6,1 lg CFU/g. Bacteria of the Enterobacteriaceae family were defined in 61 % of cases in an amount of 3,1-5,4 lg CFU/g. Fungi of the genus Candida were detected in 59 % of the samples in the amount of 104-107 CFU. Bacteria characterized by cytotoxic, hemolytic and lecithinase activity were often detected in comparison with healthy people. Conclusion. The study revealed pathological microbiocenosis of upper gastrointestinal tract with opportunistic pathogens presence with factors of pathogen and cytotoxicity in patients with GERD associated with DGER, that define chronic inflammatory changes in the mucous membranes.

      1. Лазебник Л. Б., Ткаченко Е. И., Абдулганиева Д. И. и соавт. Национальные рекомендации по диагностике и лечению кислотозависимых и ассоциированных с Helcobacter pylori заболеваний (V Московские соглашения). Гастроэнтерология Санкт-Петербурга. - 2015. - № 3-4. - С. 12-18.
      2. Hopper A. D. Improving the diagnosis and management of GORD in adults. Practitioner. - 2015. - № 259 (1781). - P. 27-32.
      3. Чернин В. В., Бондаренко В. М., Червинец В. М. и соавт. Helicobacter pylori как составная часть микробиоценоза микрофлоры эзофагогастродуоденальной зоны в норме и при патологии. Экспериментальная и клиническая гастроэнтерология. - 2011. - № 8. - С. 66-72.
      4. Джулай Г. С., Секарева Е. В., Червинец В. М. и соавт. Гастроэзофагеальная рефлюксная болезнь, ассоциированная с дуоденогастроэзофагеальным рефлюксом, у больных с билиарной патологией: особенности течения и микробного биоценоза эзофагогастродуоденальной зоны. Терапевтический архив. - 2014. - № 2. - С. 17-21.
      5. Маев И. В., Гуленченко Ю. С., Андреев Д. Н. и соавт. Дуоденогастроэзофагеальный рефлюкс: клиническое значение и подходы к терапии. Consilium Medicum. - 2014. - Т. 16, № 8. - С. 5-8.
      6. Самсонов А. А., Голубев Н. Н., Андреев Н. Г. и соавт. Подходы к диагностике и лечению гастроэзофагеальной рефлюксной болезни в сочетании с дуоденогастроэзофагеальным рефлюксом. Фарматека. - 2012. - № 10. - С. 10-15.
      7. Kahrilas P. J., Keefer L., Pandolfino J. E. Patients with refractory reflux symptoms: What do they have and how should they be managed. J. Neurogastroenterol. Motil. - 2015. - № 27 (9). - P. 1195-2001.
      8. Bredenoord A. J., Hemmink G. J.M., Smout A. J.P.M. Relationship between gastro-oesophageal reflux pattern and severity of mucosal damage. J. Neurogastroenterol. Motil. - 2009. - № 21 (8). - P. 807-812.
      9. Вёрткин А. Л. Коморбидность: история, современное представление, профилактика и лечение. Кардиоваскулярная терапия и профилактика. - 2015. - Т. 14, № 2. - С. 74-79.
      10. Ткаченко Е. И., Орешко Л. С., Ситкин С. И. Гастроэнтерология XXI века с позиций многомерной биологии. Гастроэнтерология Санкт-Петербурга. - 2012. - № 2-3. - С. 2-4.
     


    Full text is published :
    Dzhulay G.S., Mikhaylova E.S., Dzhulay T.E., Samoukina A.M. MICROBIOCENOSIS OF UPPER GASTROINTESTINAL TRACT IN PATIENTS WITH GASTROESOPHAGEAL REFL UX DISEASE, ASSOCIATED WITH BILIARY PATHOLOGY. Experimental and Clinical Gastroenterology Journal. 2017;142(06):09-14
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    1. FSBEI HE Academician Ye. A. Vagner PSMU MOH Russia (Perm, Russian Federation)

    Keywords:peptic duodenal ulcer,acute gastrointestinal bleeding,arterial hypertension,hemostasis,morning surge in blood pressure

    Abstract:A comparative evaluation of the «morning load» of blood pressure and the hemostatic system in patients with peptic duodenal ulcer associated with arterial hypertension after acute gastrointestinal bleeding had been done. The study included 45 patients with hypertension who underwent gastrointestinal bleeding and 63 patients with gastrointestinal bleeding without hypertension. The combination of the activation of blood coagulation in the morning with an excessive morning rise of systolic blood pressure in hypertensive patients with duodenal ulcer complicated by acute bleeding, may be an important and a predisposing factor for the development threatening cardiovascular events: sudden death, stroke and / or myocardial infarction.

      1. Артериальная гипертония и ассоциированные с ней заболевания/Под общ. ред. проф. А. В. Туева. - Пермь: Пресс-тайм, 2007. - 416 с.
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      4. Лебедев Н. В., Климов А. Е., Петухов В. А. Повторный эндоскопический гемостаз как альтернатива хирургическому лечению больных с язвенными гастродуоденальными кровотечениями. Журнал: Хирургия. Журнал им. Н. И. Пирогова 2016; 6: 52-56.
      5. Лычев В. Г. Диагностика и лечение диссеминированного внутрисосудистого свертывания. - 2-е изд., перераб. и доп. - М.: Медицинская книга; Н.Н.: Изд-во НГМА, 2001. - 192 с. Михеева О. М. Язвенная болезнь у пожилых пациентов с артериальной гипертонией. Клиническая геронтология 2008; 1: 17-29.
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      8. Трошкина А. А., Потешкина Н. Г. Артериальная гипертензия при коморбидной патологии, вопросы терапии. РМЖ 2015; 27: 1630-1632.
      9. Kaplan N. M. Morning surge in blood pressure. Circulation 1997; 96: 19-21.
      10. Slergio G. S., Vemmos K. N., Pliarchopoulou K. M. et al. Parallel morning and evening surge in stroke onset, blood pressure and physical activity. Stroke 2002; 33: 1480-1486.
     


    Full text is published :
    Kravtsova T.Yu., Zarivchatsky M.F., Aleeva N.G.. Blinov S.A. MORNING SURGE IN BLOOD PRESSURE AND HEMOSTASIS IN PATIENTS WITH ARTERIAL HYPERTENSON ASSOCIATED WITH PEPTIC DUODENAL ULCER AFTER ACUTE GASTROINTESTINAL BLEEDING. Experimental and Clinical Gastroenterology Journal. 2017;142(06):15-19
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    1. Izhevsk State Medical Academy (Izhevsk, Russian Federation)

    Keywords:ulcer stomach disease,chronic duodenal insufficiency,vegetative status,personal and situational anxiety,quality of life

    Abstract:Purpose. The aim of the study was to analyze the vegetative status, personal and situational anxiety and quality of life in patients with peptic ulcer disease with associated chronic duodenal insufficiency (CDI), as well as the contingency of their changes with indicators of the functional state of duodenum. Materials and methods. The complex study conducted 106 patients with ulcer disease with associated CDI (observation group) and 30 patients without CDI (group of comparison). Verification of ulcer disease was performed clinically and by fibrogastroduodenoscopic researches. In determination of chronic duodenal insufficiency there were used the cavitary manometry. We have studied motor performance of the stomach and gastroduodenal ulcer with a help of peripheral electrogastrograph EGG-4М. The study of the state of the autonomic nervous system was conducted by autonomic tone (AT), autonomic reactivity (AR) and software vegetative (SV). In determining the type of temperament was used the test Eysenck questionnaire, in the assessing of trait anxiety (TA) and situational anxiety (SA) - test questionnaire Spielberg Hanina. In definition of quality of life (QL) was performed by using the SF-36 questionnaire. Results. The majority of patients from observation group was haved sympathicotonia with enhanced indicators of SA and IN. The level of coefficient of correlation power of the stomach/ duodenum was reduced postprandial against the comparison group. The vegetative status of patients with gastric ulcer without CDI was characterized by eutoniya with high AR and normal SV. The vegetative status of patients with duodenal ulcer without CDI was characterized by parasympathikotoniya, reduced AR, excess SV. In the comparison group the levels of TA and SA were reduced in relation to the observation group, the levels of the coefficient of correlation power of the stomach / duodenum have normokinetic values. The patients with ulcer disease with associated CDI have significant changes in quality of life, manifested in the reduction of the mental and physical well-being. Conclusion. Chronic duodenal insufficiency in patients with ulcer disease have a functional character, resulting from infringements of the vegetative regulation and psycho-emotional status.

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      12. Колесникова, И. Ю. Особенности дуоденогастрального рефлюкса при язвенной болезни двенадцатиперстной кишки и его динамика после эрадикации Helicobacter pylori. Экспериментальная и клиническая гастроэнтерология, 2011, № 5, с.16-19.
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    Full text is published :
    Vahrushev Yu.M., Busygina M.S. THE EVALUATION OF VEGETATIVE STATUS, PSYCHO-EMOTIONAL STATE AND QUALITY OF LIFE IN PATIENTS WITH ULCER STOMACH AND DUODENI DISEASE ASSOCIATED WITH CHRONIC DUODENAL INCUFFI CIENSY. Experimental and Clinical Gastroenterology Journal. 2017;142(06):20-25
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    1. Federal Budget Institution of Science “Central Research Institute of Epidemiology” of The Federal Service on Customers’ Rights Protection and Human Well-being Surveillance (Moscow, Russian Federation)

    Keywords:acute intestinal infections,children,the rotavirus infection

    Abstract:Acute intestinal infections (AII) are important for clinical practice. Many experts shows that there are the change in the etiological structure of AII in children. There is a dominance of pathogens of viral etiology, primarily rotavirus. However, in recent years there is growing importance of combined forms of viral AII. This requires the establishment of the characteristics of their clinical manifestations. In the article there are results of own long-term observations, showing the peculiarities of the clinical appearances of rotavirus infection and its combined form (with a norovirus infection, salmonellosis and antibioticassociated diarrhea) in children.

      1. Инфекционная заболеваемость в Российской Федерации за январь-декабрь 2015 года (по данным формы № 1 «Сведения об инфекционных и паразитарных заболеваниях») [Электронный ресурс]. - Режим доступа: http://www.rospotrebnadzor.ru/activities/statistical-materials/statictic_details.php? ELEMENT_ID=5525 - (дата обращения 10.02.2016).
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      3. О состоянии санитарно-эпидемиологического благополучия населения в Российской Федерации в 2014 году: Государственный доклад. - М.: Федеральная служба по надзору в сфере защиты прав потребителей и благополучия человека. - 2015. - 206 с.
      4. Подколзин А. Т. Эпидемиологическая и клиническая характеристика острых кишечных инфекций вирусной этиологии в российской федерации / Подколзин Александр Тихонович/ / Автореферат дисс. на соиск. уч. ст. д. м.н. Москва - 2015 г. - 46 с.
      5. Rosefeldt, V. Viral etiology and incidence of acute gastroenteritis in young children attending day-care centres / Rosefeldt V., Vescari T., Pang X. L. / Pediatrics Infection Diseases // 2005, Vol. 24. - p. 962-965.
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      10. Staat, M. A. Clinical presentations of rotavirus infection among hospitalized children / M. A. Staat, P. H. Azimi, T. Berke et al.// Pediatr Infect Dis J. -2002. - Vol.21(3). - P.221-227.
      11. Голубев А. О. Клинико-иммуноллогические особенности сочетанных сальмонеллезов у детей и иммунотерапия постинфекционного бактерионосительства: Автореф. дис. … канд. мед. наук. М. - 2013. 22 с.
      12. Sanderson, С. Global review of rotavirus morbidity and mortality data by age and region / Sanderson С., Clark А., Taylor D., Bolanos В. http://www.who.int/immunization/sage/meetings/2012/april/Sanderson_et_al_SAGE_April_rotavirus.pdf -Date of access: 24.08.2016.
      13. Анохин, В. А. Ротавирусная инфекция у детей: современные аспекты диагностики и лечения / В. А. Анохин, С. В. Халиуллина, О. И. Биккинина, К. В. Сушников // Практическая медицина. - 2009. - № 7 (39). - С. 41-45.
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    Ploskireva A.A., ROTAVIRUS INFECTION IN CHILDREN AND ITS COMBINED FORMS. Experimental and Clinical Gastroenterology Journal. 2017;142(06):26-30
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    1. FDO FGBOU IN “Russian Research Medical University. Pirogov “of Ministry of Health of Russia (Moscow, Russian Federation)
    2. GBUZ “Children’s Regional Clinical Hospital” (Krasnodar, Russian Federation)
    3. FGBOU IN “Kuban State Medical University,” Health Ministry of Russia (Krasnodar, Russian Federation)

    Keywords:digestive tract,children,congenital heart defects,small anomalies of heart development

    Abstract:The results of the study of morpho-functional state of the upper gastrointestinal tract in children with congenital anomalies of the heart and small development. The study involved 324 child with congenital heart and small anomaly of development between the ages of 1 month to 15 years. Boys 170, girls 154 children were divided into groups: 138 children with congenital malformations, the second 186 children with minor heart anomalies. It was found that children with congenital frequently detected erosive and ulcerative diseases in children with small heart-surface anomalies gastroduodenitis, reflux disorders. On the morphological and functional state of the upper gastrointestinal traktau children with congenital anomalies of the heart and small influence the state of chronic hypoxia.

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      2. Калмыкова, А. С. Частота встречаемости артериальной гипертензии у подростков г. Ставрополя / А. С. Калмыкова, Э. М. Сариева // Актуальные проблемы педиатрии: матер. 15 Конгресса педиатров России. - 2011. - С. 773.
      3. Панова, И. В. Клинико-патогенетические особенности формирования хронического гастродуоденита в сочетании с гастроэзофагеальной рефлюксной болезнью у детей в I-III стадиях полового созревания: Дис. … д-р. мед. наук / И. В. Панова// Ростов-на-Дону, 2013. - 279 с.
      4. Володин, Н. Н. Неонатология: национальное руководство/под ред. Н. Н. Володина// М.: ГЭОТАР-Медиа. - 2009. - 848 с.
      5. Баранов, А. А. Детская гастроэнтерология. Избранные главы./А.А. Баранов, Е. В. Климанская, Г. В. Римарчук // М., 2002. - 592 с.
      6. Белоусов, Ю. В. Кардиологические аспекты детской гастроэнтерологии/ Матер. 14-го Конгресса детских гастроэнтерологов России. - М., 2006. - С. 50-51.
     


    Full text is published :
    Haritonova L.A., Atayants O.S., Shashel V.A., Kleschenko E.I. MORFOFUNKTSONALNYE FEATURES DIGESTIVE TRACT IN CHILDREN AND ADOLESCENTS WITH CONGENITAL AND DEVELOPMENTAL ABNORMALITIES SMALL HEART. Experimental and Clinical Gastroenterology Journal. 2017;142(06):31-33
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    1. Russian Medical Academy of Continuous Professional Education (Moscow, Russian Federation)
    2. I. M. Sechenov First Moscow State Medical University (Moscow, Russian Federation)

    Keywords:ABCB 1,P-glycoprotein,pharmacogenetics,proton pump inhibitor,omeprazole,peptic ulcer

    Abstract:Introduction. ABCB 1 gene localized on seventh chromosome encodes ABC-transporter P-glycoprotein. Proton pump inhibitors are known to be substrates of P-glycoprotein. Studies showed that C 3435T genetic polymorphism of ABCB 1 might influence proton pump inhibitors-based acid suppression and Helicobacter pylori eradication rates. From this point of view, studying the relation between C 3435T polymorphism of ABCB 1 and clinical and demographic features of peptic ulcer patients taking proton pump inhibitors may have clinical relevance. The aim of the study - to find the connection between C 3435T polymorphism of ABCB 1 and clinical and demographic features of patients with peptic ulcer taking omeprazole. Methods. Fifty peptic ulcer patients (19 men, 31 women), who were on treatment with omeprazole in Moscow clinics, aged 18-77 years (mean age 51.5±14.9 years) were enrolled. Six milliliters of venous blood were taken from patients in K2-EDTA tubes. C 3435T polymorphism of ABCB 1 gene was analyzed using real-time polymerase chain reaction (PCR). Results. CC genotype of ABCB 1 was found in 11 (22 %) patients, CT genotype - in 26 (52 %) patients, TT genotype - in 13 (26 %) patients. All genotypes were in Hardy-Weinberg equilibrium (p=0.77). There were no statistically significant differences in distribution of CC, CT, TT genotypes of ABCB 1 gene in patients depending on stomach or duodenum ulcer localization (6,8 %, 15,9 %, 9,1 % vs. 13,6 %, 34,1 %, 20,5 %, respectively), existence or absence of family history of peptic ulcer (14,3 %, 33,3 %, 9,6 % vs. 4,7 %, 23,8 %, 14,3 %, respectively), existence or absence of exacerbation after diagnosed peptic ulcer (14,8 %, 18,6 %, 3,7 % vs. 11,1 %, 37 %, 14,8 %, respectively), existence or absence of ulcer complications (15,1 %, 9,1 %, 9,1 % vs. 12,1 %, 45,5 %, 9,1 %, respectively), less than 1 cm or 1 cm and more ulcer according to gastroscopy (7,1 %, 28,6 %, 28,6 % vs. 7,1 %, 7,1 %, 21,5 %, respectively), less than 30 or 30 and more total score of GSRS scale (10 %, 30 %, 30 % vs. 5 %, 15 %, 10 %, respectively), Fisher’s Exact test, p>0.05. Conclusion. There is a high prevalence of C 3435T polymorphisms of ABCB 1 gene in peptic ulcer patients of Moscow region. There were no statistically significant differences between ABCB 1 genotype and clinical and demographic features of peptic ulcer patients.

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    Denisenko N.P., Sychev D.A., Sizova Zh.M., Grishina E.A. et al. ABCB 1 C 3435T POLYMORPHISM AND CLINICAL FEATURES OF PEPTIC ULCER PATIENTS TAKING PROTON PUMP INHIBITORS. Experimental and Clinical Gastroenterology Journal. 2017;142(06):34-39
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    1. Kharkiv national medical University (Kharkiv, Ukraine)

    Keywords:gastroesophageal reflux disease,obesity,pathogenesis,polymorphism of endothelial NO-synthase gene

    Abstract:The work describes the results of a study of gene endothelial NO-synthase (eNOS) polymorphism in patients with gastroesophageal reflex disease (GERD) combined with obesity. It is shown that even isolated GERD course occurs against changes in gene polymorphism. GERD and obesity in 48.8 % of cases occurs at a polymorphic variant of the eNOS gene (pathological genotype CC), that allows to speak about increased risk of endothelial and hemostatic disorders, in particular, the development of cardiac symptoms. These factors may contribute to the development of atypical forms of the disease, its progression and the appearance of complications.

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    Pasiyeshvili L.M., Zhelezniakova N.M., Pasiyeshvili T.M. GENETIC DETERMINANTS OF CARDIOVASCULAR RISK IN PATIENTS WITH GASTROESOPHAGEAL REFL UX DISEASE AND OBESITY. Experimental and Clinical Gastroenterology Journal. 2017;142(06):40-43
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    1. Kazan State Medical University (Kazan, Russian Federation)
    2. Kazan Federal University (Kazan, Russian Federation)
    3. Republican Clinical Hospital (Kazan, Russian Federation)

    Keywords:intestinal permeability,autoimmune hepatitis,overlap syndrome,lactulose/mannitol ratio,sucralose,triple sugar test

    Abstract:The article presented complex assessment of intestinal permeability in patients with autoimmune hepatitis (AIH) and overlap syndrome (OS). The study included 82 people: 26 patients with AIH, 26 - with OS and 30 healthy controls. All included into the study underwent a triple sugar test. There was increasing of small intestinal permeability in patients with AIH 0,11 [0,075; 0,18] (p<0,001) and OS 0,2 [0,088; 0,3] (p<0,001), comparing with control group 0,013 [0,01; 0,025]. In patients with cirrhosis, portal hypertension and liver failure intestinal permeability changes were more prominent - increasing small bowel and colonic permeability.

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    Akberova D.R., Koshkin S.A., Odintsova A.N., Abdulganieva D.I. ASSESSMENT OF THE INTESTINAL PERMEABILITY IN PATIENTS WITH AUTOIMMUNE HEPATITIS AND OVERLAP SYNDROME. Experimental and Clinical Gastroenterology Journal. 2017;142(06):44-47
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    1. I. M. Sechenov First Moscow State Medical University (Moscow, Russian Federation)

    Keywords:irritable bowel syndrome,quality of life,age,gender,type of IBS

    Abstract:Preamble and aim of the study: Irritable bowel syndrome (IBS) affects health-related quality of life (QоL). The purpose of this study is a comparative analysis of the mental and physical indicators of health conditions IBS patients depending on age, gender of patients and type of IBS. Materials and methods: In a specialized gastroenterology clinic 245 patients with IBS were investigated QoL using a questionnaire MOS SF-36. The analysis was conducted in 2 groups of patients with IBS: up to 45 years (n=125) from 45 years and older (n=120). The results of the study: IBS рatients have low rates of both physical and mental components health. With age significantly reduced QoL, due to the physical component health (PH), p<0.05. QoL by physical (FF), emotional (RE) and role functioning (RP), in the women older age subgroup is lower than in men, p<0.05. QoL indicators of IBS-C patients are lower than in IBS-D and IBS-CM patients, p<0.05. Conclusion: QOL in patients with IBS reduced in younger and older age, predominantly in women and with age even more reduced. IBS-C patients QoL is lower than at IBS-D and IBS-CM.

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    Mnatsakanyan M.G., Pogromov A.P., Dyukova G.M., Tashjian O.V. ANALYSIS OF GENDER AND AGE DIFF ERENCES IN THE QUALITY OF LIFE OF PATIENTS WITH IRRITABLE BOWEL SYNDROME. Experimental and Clinical Gastroenterology Journal. 2017;142(06):48-53
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    1. Kazan State Medical University (Kazan, Russian Federation)
    2. Kazan Federal University (Kazan, Russian Federation)
    3. Federal Research and Clinical Centre of Physical-Chemical Medicine (Moscow, Russian Federation)
    4. Moscow Institute of Physics and Technology (Moscow, Russian Federation)
    5. Republican Clinical Hospital of the Ministry of Healthcare of the Republic of Tatarstan (Kazan, Russian Federation)

    Keywords:intestinal microbiota,ulcerative colitis,inflammatory bowel diseasesmetagenome

    Abstract:The aim of the study was to evaluate the representation of the microbial community in patients with ulcerative colitis. Materials and methods. The study included 46 patients with ulcerative colitis (25 men and 21 women, aged 42,4±13.8 years, duration of the disease - 5,42 ±8.21 years). Results of sequencing of ulcerative colitis patients stool samples as well as samples from 96 healthy volunteers were used for analysis. Whole genome sequencing was carried out on the SOLiD 5500W platform (LifeTechnologies, FosterCity, CA, USA). Results. Metagenomic analysis allowed us to detect 29 classes of bacteria, including: 73 families, 154 genera, 437 species of microbes in intestinal microbiota of patients with ulcerative colitis. The prokaryotic part of microbiota formed 99.5 % (98,2 % - Bacteria, 1,8 % - Archaea), viruses - 0.5 %, eukaryotes - 0,004 % of all intestinal microbiota. Taxonomic analysis revealed changes in the relative representation of bacterial families: we observed decrease in Lachnospiraceae, Rikenellaceae, Acidaminococcaceae, Enterococcaceae, Desulfovibrionaceae, Verrucomicrobiaceae, Clostridiaceae and increase in Enterobacteriaceae. Only the number of Escherichia genus, particularly Escherichia coli species was significantly abundant among the members of Enterobacteriaceae family. In ulcerative colitis patients the fraction of Escherichia was (3,74±8,01)% which was greater than in the control group (1,49±of 5.23)%, whereas the fraction of Clostridium (1,15±3,35)% was significantly lower in patients with ulcerative colitis than in the control group (2,33±4,26)%. The alpha-diversity index which characterizes richness of the microbial community was decreased in stool samples of patients with ulcerative colitis in comparison with the control group. Conclusions. The metagenomics analysis revealed significant changes in intestinal microbiota in ulcerative colitis patients comparing with the control group.

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    Danilova N.A., Abdulkhakov S.R., Grigoryeva T.V., Markelova M.I. et al. CHANGES OF INTESTINAL MICROBIOTA IN PATIENTS WITH ULCERATIVE COLITIS. Experimental and Clinical Gastroenterology Journal. 2017;142(06):54-60
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