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CLINICAL PHARMACOLOGY

    1. North-Western State Medical University named after I. I. Mechnikov (St. Petersburg, Russian Federation)
    2. Saint-Petersburg State Pediatric Medical University (St. Petersburg, Russian Federation)

    Keywords:Candidiasis,metabolic syndrome,treatment

    Abstract:The article presents modern principles of diagnostics and treatment of candidiasis of the upper digestive tract (oropharynx and esophagus) described the clinical picture and complications of this disease. Metabolic syndrome, occurring with disorders of carbohydrate metabolism - a typical risk factor for candidiasis. Standard for diagnosis is the detection of filamentous forms (pseudomycelium) of micromycetes of the genus Candida a morphological study of biomaterials mucous membrane. Culture of biopsy specimens with identification of the species of the pathogen becomes mandatory for maintaining tolerance to standard treatment or recurrent candidiasis. The drug of choice when treating candidiasis is fluconazole, however, in some cases, necessary alternative antimycotic drugs. Feature of the treatment of candidiasis in patients with the metabolic syndrome is an increased risk of drug damage to the cookies, especially against the background of steatosis and steatohepatitis, which is characteristic for this category of patients.

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    Full text is published :
    Shevyakov M.A. , Uspenskiy Yu.P. FEATURES DIAGNOSIS AND TREATMENT OF CANDIDIASIS OF THE UPPER DIGESTIVE TRACT IN PATIENTS WITH METABOLIC SYNDROME. Experimental and Clinical Gastroenterology Journal. 2017;143(07):161-166
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    1. Pirogov Russian National Research Medical University (RNRMU) (Moscow, Russian Federation)
    2. I. M. Sechenov First Moscow State Medical University (Moscow, Russian Federation)
    3. Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» of the Ministry of Health of the Russian Federation (Moscow, Russian Federation)

    Keywords:gastroparesis,dopamine receptors,prokinetics,omeprazole,domperidone

    Abstract:The purpose of review: to determine clinical and pharmacological approaches to the choice of gastroparesis therapy. Basic provisions. Prokinetics are medicines that accelerate the movement of content along the digestive tract, affecting dopamine, serotonin, acetylcholine, motilin, cholecystokinin and other receptors. Fixed combination of the proton pump inhibitor and prokinetic proved effective in the therapy of stomach functional disorders. In clinical study on the efficacy and safety of the combination of omeprazole and domperidone sustained release in patients with gastroesophageal reflux disease of mild or moderate severity, according to NNT criteria, it was shown that the drug containing 20 mg omeprazole and 30 mg of domperidone sustained release is very good preparation for the full cupping reflux symptoms (NNT = 2.5), and a good drug for the elimination of esophagitis (NNT = 3,7). It is also shown that this combination is well tolerated (very good and good tolerability at 100 %) and is safe (the frequency of adverse mild degree reactions of 6.7 %, 95 % CI = 0,8-22,1). Conclusion. The use of a combination of omeprazole and domperidone sustained release in gastroparesis is pathogenetically justified. The clinical efficacy and safety of a formulation containing a fixed combination of 20 mg of omeprazole and 30 mg of domperidone sustained release in the treatment of gastroparesis are high.

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    Full text is published :
    Kareva E.N., Serebrova S.Yu. CHALLENGES IN DRUG TREATMENT OF GASTRIC MOTILITY DISORDERS . Experimental and Clinical Gastroenterology Journal. 2017;143(07):167-183
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