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    1. Research Institute of Internal and Preventive Medicine - Branch of Federal State Budget Scientefic Institution The Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences
    2. National Research State University

    Keywords: pancreatic cancer, meta-analysis, prospective cohort studies, risk, coffee, tea

    Abstract:Pancreatic cancer (PC) is one of the top 5 causes of mortality from cancer. The role of dietary factors in the etiology of PC is unclear. We reviewed some meta-analytical or pooled reports dealing with the association between coffee (C) and tea (T) consumption and PC risk. C components can have anticarcinogenic effect: meta-analysis by Dong (2011) confirmed, that pooled relative risk (RR) of PC in high C lovers comparing with non/lowest C drinkers was 0.68 (95% CI 0.51-0.84). But in the “US NIH-AARP Diet and Health Study” (2015) after adjustment for smoking, PC risk were not significant: never C drinkers compared with C drinkers≥6 cups per day (cpd) HR1.24 (0.93-1.65). In the European Prospective Investigation (2013) neither C, nor T were also associated with PC risk, but the previous Italian multicenter study (1995) was demonstrated, that ingestion of >3 cpd lead to significantly increased PC risk (odds ratio (OR) 2.53; 1.53-4.18). A meta-analysis by Zeng (2014) indicate, that green T consumption >2 cpd (OR0.95, 0.85-1.06) was not associated with PC risk. However, the subgroup analysis of different countries in meta-analysis by Chen (2014) showed a statistical decrease in PC risk by high T consumption in a Chinese population (Risk ratio=0.76, 0.59-0.98). Nevertheless meta-analysis, pooled and case-control studies are prone to some limitations (recall, selection bias) - different dietary patterns, adjustment for different confounders, etc. Further research is needed to clarify the biological mechanisms in the possible inverse relationship between C, T intake and PC risk.

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    Full text is published :
    PANCREATIC CANCER RISK FACTORS: A SUMMARY REVIEW OF META-ANALYTICAL AND PROSPECTIVE COHORT STUDIES PART 1. COFFEE AND TEA CONSUMPTION. Experimental and Clinical Gastroenterology Journal. 2018;151(03):93-96
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    1. National Research Ogarev Mordovia State University

    Keywords: pancreatitis, diagnostics, treatment, pregnancy

    Abstract:The article gives up-to-date information about the most frequent, clinical pictures, diagnostics methods, differential diagnostics and treatment pancreatitis during pregnancy.

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    Full text is published :
    PANCREATITIS IN PREGNANCY. Experimental and Clinical Gastroenterology Journal. 2018;151(03):97-104
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    1. Saint-Petersburg University
    2. Ott Research Institute of Obstetrics, Gynecology and Reproductology

    Keywords: liver, pregnancy, holestatichepatosis of pregnants, acute fatty hepatosis of pregnants, HELLP-syndrome, unrestrained vomiting of pregnants

    Abstract:Тhis article demonstrates review of relevant clinical recommendations about diagnostics, care and treatment of liver diseases at pregnants. Recommendations about an algorithm of diagnostic search of liver pathology are provided in the first message during pregnancy, with assessment of indicators changes at biochemical blood serum research of “the hepatic panel”, opportunities and indications for methods of visualization and endoscopy. The liver diseases associated with pregnancy from positions of the available recommendations are considered and also results of own observations are given.

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    DISEASES OF THE LIVER AND PREGNANCY. ANALYSIS OF ACTUAL CLINICAL GUIDELINES AND OWN EXPIRIENCE. PART ONE. LIVER DISEASES АSSOCIATED WITH PREGNANCY. Experimental and Clinical Gastroenterology Journal. 2018;151(03):105-114
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