1. “Russian Medical Academy of Continuing Professional Education” Russian Federation Ministry of Health (Moscow, Russian Federation)
2. First Moscow state medical University. I. M. Sechenov Russian Ministry Of Health (Moscow, Russian Federation)

Keywords: СYР2С19, Helicobacter pylori, eradication therapy, proton pump inhibitors

Abstract:The clinical situation in which the dependence of the result of Н. pylori eradication therapy on the genotype СYР2С19 controlling the metabolism rate of proton pump inhibitors is described. When carrying the allele variant СUR2С19 * 17 (homo-, heterozygote), a person refers to the “fast metabolizers” of this group of drugs. In view of this anti-Helicobacter therapy can not be achieved in the proper amount.

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Full text is published :
Bojko E.N., Denisenko N.P., Grishina E.A., Ryzhikova K.A. et al. THE INFLUENCE OF GENE POLYMORPHISMS СУР2С19 ON THE EFFECTIVENESS OF ERADICATION THERAPY OF H. PYLORI. Experimental and Clinical Gastroenterology Journal. 2018;154(06):160-163
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1. State funded medical institution “City clinical hospital № 15 named after O. M. Filatov” Department of healthcare of Moscow. (Moscow, Russian Federation)
2. State funded institution of higher professional education “Moscow State Medical and Dental University of A. I. Evdokimov” (Moscow, Russian Federation)

Keywords:rapidly progressing glomerulonephritis, mixed cryoglobulinemia, nephrotic and nephritic syndrome, systemic vasculitis, chronic viral hepatitis C, pulse-therapy, immunosuppressive therapy

Abstract:The present study demonstrates severe course of glomerulonephritis with underlying nephrotic and acute nephritic syndrome with rapidly progressing kidney failure and skin lesion associated with chronic viral hepatitis C. Unfortunately despite the combined immunosuppressive therapy the patient still had azotemia and the nephrotic syndrome was progressing. It was impossible to conduct antiviral therapy because of acute kidney damage, as the clearance of the pegylated interferon decreases under kidney failure. The therapy by monoclonal antibodies to CD20 was not discussed. Kidney damage remains the main cause of death of patients with mixed cryoglobulinemia. The presented clinical case emphasizes the urgency of the problem of extrahepatic aspect of chronic viral hepatitis C and proves the role of lymphotropic chronic viral hepatitis C in the mechanism of the development of rapidly progressing glomerulonephritis. The development of the scheme of modern antiviral therapy and relapse prevention is needed.

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Full text is published :
Sagynbaeva V.E., Lazebnik L.B., Golovanova E.V. RAPIDLY PROGRESSING GLOMERULONEPHRITIS WITH THE DEVELOPMENT OF SYSTEMIC CRYOGLOBULINEMIC VASCULITIS ASSOCIATED WITH CHRONIC VIRAL HEPATITIS C. Experimental and Clinical Gastroenterology Journal. 2018;154(06):164-169
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