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    1. Federal State Budgetary Educational Institution of Higher Education "National Research Ogarev Mordovia State University" (430005, Saransk, Republic of Mordovia, Russia)

    Keywords:Mechanical jaundice, endogenous intoxication, ozone

    Abstract:Purpose of the study. To assess the severity of endogenous intoxication in mechanical jaundice and to study the detoxification effect of the ozonized saline solution. Materials and methods. There were studied the results of surgical treatment of 76 patients with mechanical jaundice, divided into 2 groups. Patients in the group 1 (n = 40) underwent conventional treatment. 36 patients of the 2nd group were treated with ozonized saline solution. The following were determined: aspartate aminotransferase (ASAT), alanine aminotransferase (ALAT); common and direct bilirubin, average weight molecules (AMM), malonicdialdehyde (MDA), catalase, creatinine and urea concentration in plasma. Results. On the 15th day of the postoperative period, the levels of ALAT, AMM, MDA, creatinine, urea were decreased in patients of group 1 by 33, 36, 38, 30 and 38% respectively, the level of catalase increased by 32%. In patients of the 2nd group, the levels of ALAT, AMM, MDA, creatinine and urea decreased by 59, 56, 61, 35, 55%, whereas the catalase level increased by 65%. The conclusion. The therapy with ozonized saline solution promotes the decrease of the level of endogenous intoxication due to more pronounced activation of antioxidant system with a decrease of the level of free radical oxidation and of destructive processes in the liver.

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      16. Yanchenko O.S., Kontorshchikova Ye.Yu., Kryzhanova M.A. et al. Izmeneniya immunologicheskogo statusa u onkoginekologicheskikh bolnykh pod vliyaniem ozonirovannogo fiziologicheskogo rastvora [Changes in the immunological status of oncologic patients under the influence of ozonized saline]. Nizhegorodskiy meditsinskiy zhurnal — Nizhny Novgorod Medical Journal. 2005, pp. 115–116.
      17. Krylov V.N., Deryugina A.V., Simutis I.S. et al. Contents of ATP and 2,3-DPG in erythrocytes for preservation and ozone exposure Biomedicine. 2014, no. 2, pp. 37–42.
      18. Simutis I.S., Boyarinov G.A., Mukhin A.S. et al. Effektivnost ozonirovaniya eritrotsitarnoy massy v transfuzionnoy terapii gemorragicheskogo shoka [Efficiency of erythrocyte mass ozonization in transfusion therapy of hemorrhagic shock]. Bioradicals and Antioxidants. 2017, Vol. 4, no. 3, pp. 21–26.

    Full text is published :
    Belyaev A.N., Belyaev S.A., Kostin S.V., Tyurina N.A., Boyarkin E.V. Endogenous intoxication in mechanical joundice and the possibility of its pathogenetic correction. Experimental and Clinical Gastroenterology. 2018;157(9): 101–106. DOI: 10.31146/1682-8658-ecg-157-9-101-106.
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    1. Saratov State Medical University named after V. I. Razumovsky (410012, Saratov, Russia)

    Keywords: pancreonecrosis, purulent-necrotic parapancreatitis, necrosectomy

    Abstract:Objective: to determine the prognostic value of the complex assessment of the patient's condition (clinical examination using scales, biochemical markers, dynamic ultrasound and CT) for the timely formulation of indications for surgery in the development of purulent complications of pancreatonecrosis in the phase of septic sequestration. Material and Methods: the study included 186 patients with pancreatic necrosis. The comparison group included patients whose manifestations of the disease were limited to the development of enzymatic peritonitis. The second group includes patients who have formed peripancreatic infiltrate and (or) isolated pancreatogenic abscess. The third group consisted of patients with purulent-necrotic parapancreatitis. Results: Measurements on the SAPS III scale revealed a significant difference of scores in patients with purulent necrotic parapancreatitis and patients in the comparison group. Similar data were obtained from a comparative assessment of the severity of organ failure on the SOFA scale. The study showed a significant decrease in the serum albumin level in patients with purulent-necrotic parapancreatitis and the presence of a significant difference in this parameter with patients in the comparison group. Conclusion: With purulent-necrotic parapancreatitis, a complex assessment of the patient's condition helps timely recognize infectious complications and formulate the indications for surgical intervention. In patients with limited infected pancreatic necrosis, the use of scales and biochemical markers was not very informative.

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    Full text is published :
    Shapkin Yu.G., Khilgiyaev R.Kh., Scripal E.A. Indications to surgical treatment in patients with infected pancreonecrosis. Experimental and Clinical Gastroenterology. 2018;157(9): 107–114. DOI: 10.31146/1682-8658-ecg-157-9-107-114.
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    1. Ryazan State Medical University (390026, Ryazan, Russia)

    Keywords: chronic pancreatitis, quality of life, malabsorption syndrome

    Abstract:The purpose of this study was to study the quality of life of patients with chronic pancreatitis. An original questionnaire on the quality of life of patients with chronic pancreatitis was proposed and tested. Materials and methods: 38 operated and 40 non-operated patients with chronic pancreatitis were examined. Results. A high degree of conceptual, constructive and criterial validity, internal consistency and reproducibility of the original questionnaire scales is proved. A strong correlation was found between rs> 0,71 of the scale of digestive disorders with the severity of malabsorption syndrome (p <0.001). The proposed COLPAC questionnaire can be used for diagnostic purposes and for an individual assessment of the clinical symptoms of chronic pancreatitis. The questionnaire can serve as a reliable tool for assessing the quality of life of patients operated on for chronic pancreatitis.

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    Full text is published :
    Natalskiy A.A., Tarasenko S.V., Zaytsev O.V., Bogomolov A.Yu., Peskov О.D., Kadykova O.A. quality of life in patients with chronic pancreatitis. Experimental and Clinical Gastroenterology. 2018;157(9): 115–120. DOI: 10.31146/1682-8658-ecg-157-9-115-120.
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    1. Federal State Budgetary Institution «N.N. Blokhin National Medical Research Center of Oncology» оf the Ministry of Health of the Russian Federation (115478, Moscow, Russia)
    2. Federal State Budgetary Educational Institution of Further Professional Education "Russian Medical Academy of Continuous Professional Education" of the Ministry of Healthcare of the Russian Federation (125993, Moscow, Russia)

    Keywords: endoscopic ultrasonography, fine needle puncture efficiency, morphological verification, adrenal gland

    Abstract: Fine needle puncture under the control of endoscopic ultrasonography is a high-tech method of morphological verification of the diagnosis. This article is devoted to the review and analysis of the possibilities of fine needle puncture under the control of endosonography in the morphological verification of pathologically altered adrenal glands. The aim of the study was to explore the possibilities of fine-needle puncture under the control of the endoscopic ultrasonography in the morphological verification of space-occupying lesions of the adrenal gland. Materials and methods: the study included 59 patients who underwent endoscopic ultrasonography in the period from 2007 to 2018, 39 of them underwent fine needle puncture for morphological verification of the diagnosis. Results: to solve the tasks — morphological verification of the diagnosis in 39 patients 45 fine — needle punctures were performed, 34 (75.6%) of them were performed once, in 4 (8.8%) cases it was performed twice, in 1 (2.2%) — three times. Of the 44 performed fine-needle punctures in 4 (9.1%), its results were uninformative. The informativeness of EUS-TYPE for morphological verification was 90.9%. Complications of various kinds were not recorded Conclusion: thus, endoscopic ultrasonography in our study has demonstrated itself as a high-precision method of examination of patients, allowing to visually identify and confirm tumor changes in the adrenal glands. Taking into account the resolution of this method and the proximity of the adrenal gland to the echoendoscope sensor, performing a fineneedle puncture is the best way to obtain material for morphological verification of the diagnosis. The combination of the advantages of the method in the possibility of visualization and the minimum distance to the object of fine-needle puncture allow us to recommend this method as the main if necessary morphological verification of changes in the adrenal glands.

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    Full text is published :
    Burdyukov M.S., CHistyakova O.V., YUrichev I.N., Malihova O.A., Nechipaj A.M. Fine-needle puncture under endoscopic ultrasonography in the bulk formations of the adrenal glands. Experimental and Clinical Gastroenterology. 2018;157(9): 121–127. DOI: 10.31146/1682-8658-ecg-157-9-121-127.
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