1. Regional Clinical Hospital № 2, Krasnodar 350012, Russia

Abstract:The relevance of milk-feeding of babies, the importance of not only the composition and properties of breast milk, but also the technology of enzymatic degradation of its nutrients are cosidered In the Assembly speech. First, it is produced according to the type of its own digestion by hydrolases of the digestive glands and the small intestine of the infant, the complex of which is formed antenatally and called the starting multienzyme digestive potential in the newborn child. Its quantitative characterization is possible by determining the main digestive hydrolases in the amniotic fl uid, in the blood of the umbilical cord and in the gastric aspirate of the infant. The expression of this potential in the point system is proposed. With incomplete gestation, the digestive potential is reduced. Secondly, hydrolysis of breast milk nutrients is carried out by its own hydrolases in the autolytic type of digestion. The dynamics of secretion of hydrolases by the mammary glands of healthy women during one year of lactation was studied. The quantitative dependence of the hydrolase secretion on its value in the fi rst lactation month is described with a general tendency to a decrease in the hydrolase content in milk with an increase in the monthly lactation period, and the dependence of the secretion of enzymes by the mammary glands from the age of the pregnant women. The dynamic convergence of the multienzyme digestive potentials of the child's digestion system and the mother's milk it takes is relevant in lactotrophy. Based on the results of peptidic analysis of auto-and inragastral proteolysis of breast milk, milk hydrolases are not only considered as trophotropic participants in the degradation of its nutrients, but also in formation of by milk proteases functionally multipotent regulatory peptides with a characteristic change in their number and content in the dynamics of infant feeding and timing of gestation.

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Full text is published :
Korot’ko G. F. Lactotrophy of infants in terms of digestiology (Assembly speech). Experimental and Clinical Gastroenterology. 2019;161(1): 4–54. (In Russ.) DOI: 10.31146/1682-8658-ecg-161-1-4-54
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1. Pirogov Russian National Research Medical University (RNRMU), Moscow 117997, Russia

Keywords: children, intestinal microfl ora, microbiota, мicrobiome, humus, probiotics, рrebiotics, metabiotiсs, synbiotics, autometabiolites.

Abstract:Microbiota plays a key role in the physiology and maintenance of homeostasis of the human body. The importance belongs to the processes of the formation of the intestinal microbiota, starting in utero, and the child continues to receive the mother’s microfl ora during childbirth and breastfeeding. The results of molecular genetic studies indicate that the most intensive process of microbial colonization in infant is associated with features of feeding. The main factor in maintaining the stability and resistance of normal biota is microbial autometabiolites. Considered the most promising probiotic biotechnology and development metabolic of probiotics (metabiotics) probiotics in combination with Prebiotics (synbiotics). Understanding the processes of formation of intestinal microfl ora allows you to develop eff ective methods of prevention and correction micro-ecological and motor disorders in the age aspect.

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Kharitonova L. A., Grigoriev K. I., Borzakova S. N. Human microbiote: how a new scientifi c paradigm changes medical practice. Experimental and Clinical Gastroenterology. 2019;161(1): 55–63. (In Russ.) DOI: 10.31146/1682-8658-ecg-161-1-55-63
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