1. I . M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia
2. University children’s clinical hospital, gastroenterology Department, Moscow, Russia

Keywords: UC, teenagers, course, adherence, eff ectiveness of therapy

Abstract:The problems of ulcerative colitis (UC) in pediatric practice are the diffi culties of primary diagnosis, the severity of the course due to the greater extent of the colon lesion and the diffi culty in choosing a drug eff ect. The age of the patients determines the extent of colon lesions in UC in children. Thus, in the older age group, especially older than 15 years, characterized by a high frequency of left-sided ulcerative colitis forms in contrast to adults. The choice of therapy in children with UC depends on the severity of the condition, localization and extent of the lesion, the severity of humoral activity and the age of the child, as well as adherence (compliance) therapy. This example demonstrates that in a teenage boy ulcerative colitis had a rare localization for children, there was a violation of the recommended therapy at the beginning and dynamics of observation, which led to a relapse and progression of the disease. Low adherence to therapy signifi cantly worsened the course and prognosis of the pathological process, and therefore the quality of life of the patient.

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Full text is published :
Tahirova A. R., Sichinava I. V., Yablokova E. A., Tyurina E. N., Krutikhina S. B., Borisova E. V., Polotnyanko E. U., Frolkova E. V. Ulcerative colitis: features of the course and adherence to prescribed therapy in adolescents. Experimental and Clinical Gastroenterology. 2019;162(2): 125–130. (In Russ.) DOI: 10.31146/1682-8658-ecg-162-2-125-130
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1. FRC CSC RAS, Institute of Pharmacoinformatics, Moscow, Russia
2. Big Data Storage and Analysis Center (CCHD), Moscow State University, Moscow, Russia
3. Federal State Budgetary Educational Institution of Further Professional Education “Russian Medical Academy of Continuous Professional Education” of the Ministry of Healthcare of the Russian Federation, 2⁄1, Barrikadnaya st., Moscow, 125993, Russia

Keywords: prebiotics, dysbiosis, systematic analysis, lactitol, Exportal

Abstract:Lactitol is a prebiotic disaccharide that supports the functioning of lacto- and bifi dobacteria, also inhibits the growth of pathogenic fl ora. The results of transcriptome and proteomic studies have shown that lactitol is characterized by unique absorption and processing mechanisms in lactobacteriathat distinguish it from other prebiotics. In high doses (5 … 50 g/day) lactiol is used as an osmotic laxative. Lactictol enhances the detoxifi cation of the body (in particular, the excretion of ammonia and toxic amines). The detoxifi cation eff ect of lactitol, lack of lactitol’seff ect on blood lipid and glycemic profi les, lack of food intolerance and rare occurrenceof side eff ects (fl atulence, transient diarrhea when the dose is exceeded) make lactitol an important tool in the treatment of dysbiosis, liver disease and hepatic encephalopathy.

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Gromova O. A., Torshin I. Yu., Maximov V. A., Gromov A. N., Rudakov K. V. Systematic analysis of lactitol studies. Experimental and Clinical Gastroenterology. 2019;162(2): 131–142. (In Russ.) DOI: 10.31146/1682-8658-ecg-162-2-131-142
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1. RUDN University, Moscow, Russia
2. National Medical Research Center of Radiology, RF, Moscow, Russia
3. GBUZ Moscow Clinical Research Center named after A. S. Loginov DZM, 111123, Moscow, Russia

Keywords: iron defi ciency, iron defi ciency syndrome, infl ammatory bowel disease, treatment of anemia, sucrosomial iron, intravenous iron

Abstract:The article describes the most common iron defi ciency syndromes (IDS) in infl ammatory bowel disease (IBD) and presents the modern principles of diff erential diagnosis of gastrointestinal disease, the advantages and disadvantages of standard methods for the correction of Iron-Defi ciency (ID) and anemia in this group of patients. The authors give a circumstantial outline of their own data of examination and treatment of 77 patients with IBD and anemia, and prove the necessity of compulsory ferritin serum (FS) testing as the most important diff erential marker of the IDs., Inadequate production of erythropoietin as the main cause of anemia has been proven in 15% of patients with high FS values. On the contrary, the necessity of mandatory use of iron preparations in management of anemia was determined in 85% of patients. The high effi ciency and safety of sucrosomial iron are proven in patients with IBD and anemia. The eff ectiveness of this method shows the normalization of hemoglobin in 68% of patients within 3 months. In contrast, intravenous iron administered during the inpatient treatment period is not suffi ciently eff ective in this category of patients, which requires the continuation of outpatient therapy with preparations of sucrosomial iron. Conclusions: Based on the obtained data and international experience, there was formulated and substantiated the algorithm of diff erentiated therapy of IDS in patients with a mild form of IBD.

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Full text is published :
Stuklov N. I., Basiladze I. G., Kovalchuk M. S., Pivnik A. V., Knyazev O. V., Parfenov A. I. New options in management of Iron-Defi ciency syndromes in Infl ammatory Bowel Disease Experimental and Clinical Gastroenterology. 2019;162(2): 143–150. (In Russ.) DOI: 10.31146/1682-8658-ecg-162-2-143-150
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1. FRC CSC RAS, Institute of Pharmacoinformatics, 119333, Moscow, Vavilova, 42, Russia
2. Big Data Storage and Analysis Center (CCHD), Moscow State University, Moscow, Russia
3. Federal State Budgetary Educational Institution of Further Professional Education “Russian Medical Academy of Continuous Professional Education” of the Ministry of Healthcare of the Russian Federation, Moscow, Russia
4. Federal State Budget Educational Institution of Higher Education “Northern State Medical University” of the Ministry of Healthcare of the Russian Federation, 163000, Arkhangelsk, Troitskiy Ave., 51

Keywords: lactobacilli, probiotics, prebiotics, L. casei I-1572, Enterolactis

Abstract:The eff ectiveness of probiotics is strain-specifi c. This paper presents the results of a systematic analysis of the promising lactobacterial strain Lactobacillus paracasei CNCM I-1572 (L. casei DG; L. paracasei DG). L. casei DG well survives in the conditions of the stomach and intestines, supports the benefi cial microbiota and inhibits the growth of pathogenic bacteria, exhibits a therapeutic eff ect in ulcerative colitis, eradication of H. pylori, diverticular bowel disease, and irritable bowel syndrome.

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Full text is published :
Torshin I. Yu., Gromova O. A., Maksimov V. A., Zacharova I. N., Malavskaiya S. I. Analysis of the strain-specifi c eff ects of lactobacilli L. casei DG (L. paracasei CNCM I-1572) and the possibility of their use in clinical practice. Experimental and Clinical Gastroenterology. 2019;162(2): 151–158. (In Russ.) DOI: 10.31146/1682-8658-ecg-162-2-151-158
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1. National Research OgarevMordovia State University, 430005, Saransk, Republic of Mordovia, Russia.

Keywords: Remaxol, mechanical jaundice, hemostasis, endotoxicosis, lipid peroxidation, hypoxia

Abstract:A study of 35 patients, whom operated by obstructive jaundice of neoplastic origin was done. They were divided into 2 groups: І (comparison groups, n = 15) — in the early postoperative period patients were given standard therapy and II (studied groups, n = 20) — Remaxol was included in the scheme of traditional treatment. In the study dynamics were carried out laboratory and biochemical tests: malonic dialdehyde (MDA) and diene conjugates (DC); phosphalipase A2 (PL A2); hypoxia ratio (HR); middleweight molecules (MWM), total (TAC) and eff ective albumin concentration (EAC), toxicity index (TI), total bilirubin (TB), alanine aminotransferase (ALT), activated partial thromboplastin time (APTT) and fi brinogen. Thromboelastography (USA) was used to assess the state of the hemostasis system. It was established that postoperative patients in the early time had oxidative stress, increased phospholipase activity, endotoxicosis syndrome, hemostatic disorders (hypercoagulation and hypofi brinolysis), which persisted throughout the observation period. The inclusion Remaxol in traditional therapy led to suppression of the intensity of lipid peroxidation (LP), reduction of phospholipase activity, relief of endogenous intoxication and hypoxia, restoration of blood coagulation-lytic status. The most signifi cant eff ect of the drug was determined in the fi rst 3 days after surgery. Objective: to evaluate the pharmacological eff ects of Remaxol in patients with mechanical jaundice of non-neoplastic origin.

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Full text is published :
Vlasov A. P., Al-Kubaisi Sh-A. S., Sheyranov N. S., Markin O. V., Zaitsev P. P., Vlasova T. I., Vasiliev V. V. Clinical examples to the algorithm on management of primary patients with symptoms of dyspepsia. Experimental and Clinical Gastroenterology. 2019;162(2): 159–164. (In Russ.) DOI: 10.31146/1682-8658ecg-162-2-159-164
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