JOURNAL CONTENT
CONTACT

Submission of the manuscript is online via e-mail
ecgarticle@gmail.com or
cholerez@mail.ru

Tel: +7 903 250 5288

Editorial Correspondence e-mail
gastrossr@gmail.com


Publishing, Subscriptions, Sales and Advertising, Correspondence e-mail
journal@cniig.ru

Tel: +7 917 561 9505

THE RULES OF SUBMITTING AN ARTICLE

READ

Scimago Journal & Country Rank

SCImago Journal & Country Rank

LEADING ARTICLE

    1. The State Education Institution of Higher Professional Training The First Sechenov Moscow State Medical University under Ministry of Health of the Russian Federation (Sechenov University), 119991, Moscow, Russia
    2. Moscow State University of Medicine and Dentistry named after A. I. Evdokimov, 127473, Moscow, Russia
    3. Federal State Budget Institution “A. V. Vishnevsky National Medical Research Center of Surgery” of the Ministry of Health of the Russian Federation, 117997, Moscow, Russia

    Keywords: Renal cell carcinoma, pancreatic head metastasis, surgical treatment

    Abstract: This review reflects current data on the possibilities of surgical treatment of patients with metastases of renal cell carcinoma in the pancreas in the aspect of complex therapy. The data obtained are ambiguous due to small patient samples, the extreme rarity of metastatic lesions of this localization and the ambiguity of approaches to surgical treatment. The prerequisites for performing duodenum-preserving pancreatic head resection as an operation that has a high potential of a favorable quality of life of patients in the long-term postoperative period.

      1. Chatzizacharias NA, Rosich-Medina A, Dajani K, Harper S, Huguet E, Liau SS, Praseedom RK, Jah A. Surgical management of hepato-pancreatic metastasis from renal cell carcinoma. World J Gastrointest Oncol. 2017;9(2):70-7. https://doi.org/10.4251/wjgo.v9.i2.70.
      2. Polushin OG, Fedosenko KV, Ponomareva EV, Topuzov RE, Kislitsyna ON. Late pancreatic metastases from renal cell carcinoma: A case report. Arkhiv patologii. 2016;78(5):37-39. https://doi.org/10.17116/patol201678537-39
      3. Thadani A, Pais S, Savino J. Metastasis of renal cell carcinoma to the pancreas 13 years postnenhrectomv. Gastroenterol Hepatol (N Y). 2011; 7(10):697-699.
      4. Sperti C, Moletta L, Patanè G. Metastatic tumors to the pancreas: The role of surgery. World J Gastrointest Oncol. 2014;6(10):381-392. https://doi.org/10.4251/wjgo.v6.i10.381.
      5. Shatveryan GA, Chardarov NK, Bagmet NN, Ratnikova NP, Bedzhanyan AL, Petrenko KN, Polishchuk LO, Karagyozyan GA. Isolated pancreatic metastases of renal cell carcinoma. Khirurgiia (Mosk). 2017;(12):36-40. doi: 10.17116/hirurgia20171236-40.
      6. Lee SR, Gemenetzis G, Cooper M, Javed AA, Cameron JL, Wolfgang CL, Eckhauser FE, He J, Weiss MJ. Long-Term Outcomes of 98 Surgically Resected Metastatic Tumors in the Pancreas. Ann Surg Oncol. 2017;24(3):801-807. https://doi.org/ 10.1245/s10434-016-5619-z.
      7. Strobel O, Hackert T, Hartwig W, Bergmann F, Hinz U, Wente MN, Fritz S, Schneider L, Büchler MW, Werner J. Survival data justifies resection for pancreatic metastases. Ann Surg Oncol. 2009;16(12):3340-9. https://doi.org/ 10.1245/s10434-009-0682-3.
      8. Yagi T, Hashimoto D, Taki K, Yamamura K, Chikamoto A, Ohmuraya M, Beppu T, Baba H. Surgery for metastatic tumors of the pancreas. Surg Case Rep. 2017;3(1):31. https://doi.org/ 10.1186/s40792-017-0308-0.
      9. Kriger AG, Paklina OV, Kochatkov AV, Vetsheva NN, Filippova EM, Makeeva-Malinovskaia NIu, Berelavichus SV, Svitina KA. The metastatic invasion of pancreas by renal cancer. Khirurgiia (Mosk). 2012;(9):26-31.
      10. Cheng SK, Chuah KL. Metastatic Renal Cell Carcinoma to the Pancreas: A Review. Arch Pathol Lab Med. 2016;140(6):598-602. https://doi.org/10.5858/arpa.2015-0135-RS.
      11. David AW, Samuel R, Eapen A, Vyas F, Joseph P, Sitaram V. Pancreatic metastasis from renal cell carcinoma 16 years after nephrectomy: a case report and review of the literature. Trop Gastroenterol. 2006;27(4):175-6.
      12. Sellner F, Tykalsky N, De Santis M, Pont J, Klimpfinger M. Solitary and multiple isolated metastases of clear cell renal carcinoma to the pancreas: an indication for pancreatic surgery. Ann Surg Oncol. 2006;13:75-85. https://doi.org/ 10.1245/ASO.2006.03.064
      13. Tanis PJ, van der Gaag NA, Busch OR, van Gulik TM, Gouma DJ. Systematic review of pancreatic surgery for metastatic renal cell carcinoma. Br J Surg. 2009;96:579-592. https://doi.org/ 10.1002/bjs.6606.
      14. Karmazanovskij GG, Kriger АG, Vetsheva NN, Kochatkov AV, Berelavichus SV. Metastases to the Pancreas from Renal Carcinoma (Literature Review and Case Report). Meditsinskaya vizualizatsiya. 2012; (4):49-54. (In Russ.)
      15. Pannala R, Hallberg-Wallace KM, Smith AL, Nassar A, Zhang J, Zarka M, Reynolds JP, Chen L. Endoscopic ultrasound-guided fine needle aspiration cytology of metastatic renal cell carcinoma to the pancreas: A multi-center experience. Cytojournal. 2016;13:24. https://doi.org/ 10.4103/1742-6413.192191
      16. Grassi P, Doucet L, Giglione P, Grünwald V, Melichar B, Galli L, De Giorgi U, Sabbatini R, Ortega C, Santoni M, Bamias A, Verzoni E, Derosa L, Studentova H, Pacifici M, Coppa J, Mazzaferro V, de Braud F, Porta C, Escudier B, Procopio G. Clinical Impact of Pancreatic Metastases from Renal Cell Carcinoma: A Multicenter Retrospective Analysis. PLoS One. 2016;11(4): e0151662. https://doi.org/ 10.1371/journal.pone.0151662.
      17. Grassi P, Verzoni E, Mariani L, De Braud F, Coppa J, Mazzaferro V, Procopio G. Prognostic role of pancreatic metastases from renal cell carcinoma: results from an Italian center. Clin Genitourin Cancer. 2013;11(4):484-8. https://doi.org/ 10.1016/j.clgc.2013.04.022.
      18. Heng DY, Xie W, Regan MM, Warren MA, Golshayan AR, Sahi C, Eigl BJ, Ruether JD, Cheng T, North S, Venner P, Knox JJ, Chi KN, Kollmannsberger C, McDermott DF, Oh WK, Atkins MB, Bukowski RM, Rini BI, Choueiri TK. Prognostic factors for overall survival in patients with metastatic renal cell carcinoma treated with vascular endothelial growth factor-targeted agents: results from a large, multicenter study. J Clin Oncol. 2009;27(34):5794-9. https://doi.org/ 10.1200/JCO.2008.21.4809.
      19. Sternberg CN, Davis ID, Mardiak J, Szczylik C, Lee E, Wagstaff J, Barrios CH, Salman P, Gladkov OA, Kavina A, Zarbá JJ, Chen M, McCann L, Pandite L, Roychowdhury DF, Hawkins RE. Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial. J Clin Oncol. 2010;28(6):1061-8. https://doi.org/ 10.1200/JCO.2009.23.9764.
      20. Jakubowski CD, Vertosick EA, Untch BR, Sjoberg D, Wei E, Palmer FL, Patel SG, Downey RJ, Strong VE, Russo P. Complete metastasectomy for renal cell carcinoma: Comparison of five solid organ sites. J Surg Oncol. 2016;114(3):375-9. https://doi.org/ 10.1002/jso.24327.
      21. Nakagohri T, Konishi M, Inoue K, Nakamura T, Kinoshita T. Partial pancreatic head resection for pancreatic metastasis from renal cell carcinoma. Hepatogastroenterology. 2003;50(54):2236-8.
      22. Moletta L, Milanetto AC, Vincenzi V, Alaggio R, Pedrazzoli S, Pasquali C. Pancreatic secondary lesions from renal cell carcinoma. World J Surg. 2014;38(11):3002-6. https://doi.org/ 10.1007/s00268-014-2672-2.
      23. Motzer RJ, Mazumdar M, Bacik J, Berg W, Amsterdam A, Ferrara J. Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma. J Clin Oncol. 1999;17(8):2530-40. https://doi.org/10.1200/JCO.1999.17.8.2530.
      24. Nihei K, Sakamoto K, Suzuki S, Mishina T, Otaki M. A Case of Pancreatic Metastasis of Renal Cell Carcinoma. Gan To Kagaku Ryoho. 2016;43(12):2274-2276.
      25. Ko S, Yun S, Kim S, Kim TN, Seo HI. Pancreatic resection for renal cell carcinoma metastasis: a case review. Ann Hepatobiliary Pancreat Surg. 2017;21(3):176-179. https://doi.org/ 10.14701/ahbps.2017.21.3.176.
      26. Santoni M, Conti A, Partelli S, Porta C, Sternberg CN, Procopio G, Bracarda S, Basso U, De Giorgi U, Derosa L. Surgical resection does not improve survival in patients with renal metastases to the pancreas in the era of tyrosine kinase inhibitors. Ann Surg Oncol. 2015;22:2094-2100. https://doi.org/ 10.1245 / s10434-014-4256-7.
      27. Kalra S, Atkinson BJ, Matrana MR, Matin SF, Wood CG, Karam JA, Tamboli P, Sircar K, Rao P, Corn PG, Tannir NM, Jonasch E. Prognosis of patients with metastatic renal cell carcinoma and pancreatic metastases. BJU Int. 2016;117(5):761-5. https://doi.org/ 10.1111/bju.13185.
      28. Maeda H, Okabayashi T, Nishimori I, Kobayashi M, Sugimoto T, Kohsaki T, Onishi S, Hanazaki K. Duodenum-preserving pancreatic head resection for pancreatic metastasis from renal cell carcinoma: a case report. Langenbecks Arch Surg. 2007;392(5):649-52. https://doi.org/ 10.1007/s00423-007-0204-3
      29. Ballarin R, Spaggiari M, Cautero N, De Ruvo N, Montalti R, Longo C, Pecchi A, Giacobazzi P, De Marco G, D’Amico G. Pancreatic metastases from renal cell carcinoma: the state of the art. World J Gastroenterol. 2011;17:4747-4756. https://doi.org/ 10.3748/wjg.v17.i43.4747.
      30. Beger HG, Krautzberger W, Bittner R, Büchler M, Limmer J. Duodenum-preserving resection of the head of the pancreas in patients with severe chronic pancreatitis. Surgery. 1985;97(4):467-73.
      31. Ahn YJ, Kim SW, Park YC, Jang JY, Yoon YS, Park YH. Duodenal-preserving resection of the head of the pancreas and pancreatic head resection with second-portion duodenectomy for benign lesions, low-grade malignancies, and early carcinoma involving the periampullary region. Arch Surg. 2003;138(2):162-8; discussion 168.
      32. Beger HG, Nakao A, Mayer B, Poch B. Duodenum-preserving total and partial pancreatic head resection for benign tumors-systematic review and meta-analysis. Pancreatology. 2015;15(2):167-78. https://doi.org/ 10.1016/j.pan.2015.01.009.
      33. Hatori T, Kimijima A, Fujita I, Furukawa T, Yamamoto M. Duodenum-preserving total pancreatectomy for pancreatic neoplasms. J Hepatobiliary Pancreat Sci. 2010;17(6):824-30. https://doi.org/ 10.1007/s00534-009-0225-0.
      34. Bassi C, Butturini G, Falconi M, Sargenti M, Mantovani W, Pederzoli P. High recurrence rate after atypical resection for pancreatic metastases from renal cell carcinoma. Br J Surg. 2003;90:555-559. https://doi.org/ 10.1002/bjs.4072
      35. Kimura W, Nagai H. Study of surgical anatomy for duodenum-preserving resection of the head of the pancreas. Ann Surg. 1995;221(4):359-63.
      36. Kimura W, Morikane K, Futakawa N, Shinkai H, Han I, Inoue T, Muto T, Nagai H. A new method of duodenum-preserving subtotal resection of the head of the pancreas based on the surgical anatomy. Hepatogastroenterology. 1996;43(8):463-72.
      37. Nakao A. Pancreatic head resection with segmental duodenectomy and preservation of the gastroduodenal artery. Hepatogastroenterology. 1998;45(20):533-5.
      38. Isaji S, Kawarada Y. Pancreatic head resection with second-portion duodenectomy for benign lesions, low-grade malignancies, and early stage carcinomas involving the pancreatic head region. Am J Surg. 2001;181(2):172-6.
      39. Zerbi A, Ortolano E, Balzano G, Borri A, Beneduce AA, Di Carlo V. Pancreatic metastasis from renal cell carcinoma: which patients benefit from surgical resection? Ann Surg Oncol. 2008;15:1161-1168. https://doi.org/ 10.1245/s10434-007-9782-0.
     


    Full text is published :
    Zharikov Yu. O., Tupikin K. A., Baidarova M. D., Pozharskaya A. A. Metastatic renal cell carcinoma in the head of pancreas: the possibility of surgical treatment. Experimental and Clinical Gastroenterology. 2019;164(4): 4–9. (In Russ.) DOI: 10.31146/1682-8658-ecg-164-4-4-9
    Read & Download full text