1. Samara state medical university (Samara, Russian Federation)

Keywords:comorbid pathology,chronic obstructive pulmonary disease,Caroli ‘s disease

Abstract:Idiopathic cystic expansion of the intrahepatic ducts (Caroli’s disease) is a congenital hereditary disease, inherited as an autosomal recessive trait. To improve the prognosis in case of cholangitis appointed antibiotics. When intrahepatic stones and / or the presence of biliary sludge successfully used ursodeoxycholic acid. Described clinical case management of the patient with acute exacerbation of chronic obstructive pulmonary disease (COPD) and Caroli disease. Antibacterial COPD exacerbations correction contributed to the prevention of cholangitis with improved liver function due antiholestatic and hepatoprotective effect of ursodeoxycholic acid. Integrated approach to comorbidity status of the patient achieves the highest compliance.

• References total 14 ⇓ :: .
  1. Haubrich W. S. Caroli of Caroli’s disease. Gastroenterology 2000; 118 (3): 486.
  2. Gunay-Aygun M., Font-Montgomery E., Lukose L. et al. Characteristics of Congenital Hepatic Fibrosis in a Large Cohort of Patients With Autosomal Recessive Polycystic Kidney Disease. Gastroenterology 2012; 144 (1): 112-121.
  3. Gevers T. J.G., Inthout J., Caroli A. et al. Young Women With Polycystic Liver Disease Respond Best to Somatostatin Analogues: A Pooled Analysis of Individual Patient Data. Gastroenterology 2013; 145 (2): 357-365.
  4. Strazzabosco M., Somlo S. Polycystic liver diseaeses: congenital disorders of cholangiocyte signaling. Gastroenterology 2011; 140: 1855-1859.
  5. Sato Y., Ren X. S., Nakanuma Y. Caroli’s disease: Current knowledge of its biliary pathogenesis obtained from an orthologous rat model. Int J Hepatol. 2012;2012:107945.
  6. Sato Y., Ren X. S., Nakanuma Y. Caroli’s disease: Current knowledge of its biliary pathogenesis obtained from an orthologous rat model. Int J Hepatol. 2012;2012:107945.
  7. Kerr S. E., Barr Fritcher E. G., Campion M. B. Biliary dysplasia in primary sclerosing cholangitis harbors cytogenetic abnormalities similar to cholangiocarcinoma. Human pathology 2014; 45 (9): 1797-1804.
  8. Lewis J. T., Talwalkar J. A., Rosen C. B. et al. Precancerous bile duct pathology in end-stage primary sclerosing cholangitis, with and without cholangiocarcinoma. Am J SurgPathol. 2010; 34: 27-34.
  9. Rizvi S., Gores G. J. Pathogenesis, Diagnosis and Management of Cholangiocarcinoma. Gastroenterology 2013; 145 (6): 1215-1229.
  10. Cetta F., Baldi C., Montalto G. et al. Intrahepatic gallstones associated with congenital bile duct dilatation restricted to the intrahepatic ducts (Caroli’s disease) are frequently cholesterol and sometimes resemble in shape the cast of dilated ducts. Gastroenterology 2000; 118 (4): A7.
  11. Drenth J. P., Chrispijn M., Nagorney D. M. et al. Medical and surgical treatment options for polycystic liver disease. Hepatology 2010; 52: 2223-2230.
  12. Григорьева И. Н. Билиарный сладж. РЖГГК 2009; 19 (3): 32-37. (Grigor’eva I. N. Biliary sludge. RZhGGK 2009; 19 (3): 32-37.)
  13. Ивашкин В. Т., Широкова Е. И., Маевская М. В. с соавт. Клинические Рекомендации Российской Гастроэнтерологической ассоциации Российского Общества по изучению печени по диагностике и лечению холестаза. РЖГГК 2015; 2: 41-57. (Ivashkin V. T., Shirokova E. I., Maevskaja M. V. et al. Clinical Recommendations Russian Gastroenterological Association of Russian Society for the Study of Liver for the diagnosis and treatment of cholestasis. RZhGGK 2015; 2: 41-57.).
  14. Celli B. R. Change in the BODE index reflects disease modification in COPD: lessons from lung volume reduction surgery. Chest 2006; 129 (4): 873-878.

Full text is published :
CAROLI DISEASE IN PATIENT WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE. Experimental and Clinical Gastroenterology Journal. 2017;138(02):110-113
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