1. Volgograd State Medical University (Volgograd, Russian Federation)

Keywords:non-alcoholic fatty liver disease,chronic heart failure,carbohydrate and fat metabolism,fatty liver index (FLI-index) index of fibrosis (NFS-index),ultrasonographic class of liver damage

Abstract:The aim of the study was to determine the relationship between the presence of disorders of carbohydrate and lipid metabolism with the structural changes of the liver in patients with ischemic chronic heart failure and non-alcoholic fatty liver disease. Materials and methods. The study included 120 patients aged 45 to 65 years old with I-III functional class chronic heart failure, myocardial infarction from 6 to 12 months. All patients had symptoms of metabolic syndrome and diabetes mellitus type 2. Patients analyzed anthropometric data, blood pressure measurement, evaluation of the content of visceral fat, level of liver markers damage, carbohydrate and lipid metabolism by conventional laboratory techniques; HOMA insulin resistance index was calculated by Mattews D. and metabolic index by Roitberg G. E.; perform calculations steatosis index (FLI) and liver fibrosis (NFS), liver ultrasonography. Results: In patients with chronic heart failure and non-alcoholic fatty liver disease FLI - index and NFS - index significantly correlated with higher levels of LDL cholesterol and triglyceride levels, decrease of HDL cholesterol and high metabolic index. Increasing FLI-index significantly correlated with the percentage of visceral fat. The level of glycated hemoglobin was significantly higher in the group with initial ultrasonographic evidence of NAFLD. FLI - index significantly correlated with level of GGT, whereas the NFS - index correlated with level of alkaline phosphatase in the group IB - IC ultrasonic classes of hepatic steatosis. Conclusion: we have identified a relationship between disorders of carbohydrate and lipid metabolism with the structural changes of the liver in patients with ishemic chronic heart failure and non-alcoholic fatty liver disease.

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THE LIVER MORPHOLOGY IN NONALCOHOLIC FATTY LIVER DISEASE DEPENDING ON THE DEGREE OF ABNORMALITIES OF CARBOHYDRATE AND LIPID METABOLISM IN PATIENTS WITH CORONARY ARTERY DISEASE AND HEART FAILURE. Experimental and Clinical Gastroenterology Journal. 2017;138(02):38-44
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1. Federal State Budget Educational Institution of Higher Education «Stavropol State Medical University» Health Ministry of Russian Federation (Stavropol, Russian Federation)

Keywords:nonalcoholic fatty liver disease,nonalcoholic steatohepatitis,liver fibrosis,adhesion molecules,immunoglobulins superfamily

Abstract:Aim of the work was to study relationship of molecules of immunoglobulins superfamily with histological variants of nonalcoholic fatty liver disease. Material and methods. Blood levels of parameters of immunoglobulins superfamily (ICAM-1, VCAM-1, PECAM-1) were studied in 40 patients (23 men, 17 women) with histologically proven nonalcoholic fatty liver disease in relationship with morphological changes in liver. Severe liver steatosis was revealed in 47.5 % of patients, nonalcoholic steatohepatitis was observed in 57.5 % of cases, moderate and severe liver fibrosis was present in 70 % of patients. The control group included 60 healthy volunteers. Results. The blood concentration of all adhesion molecules was increased in nonalcoholic fatty liver disease. The levels of ICAM-1 and VCAM-1 in blood increased and levels of PECAM-1 decreased with intensifying of fatty liver infiltration, reaching extreme values in cases of severe steatosis. Positive correlation between ICAM-1 and degree of steatosis was determined. In patients with parameters of nonalcoholic steatohepatitis score (NAS-II) of 5 and more points levels of ICAM-1 and VCAM-1 in blood were higher, than in group of patients with the minimal values of scale. Positive correlation of ICAM-1 and VCAM-1 with values of nonalcoholic steatohepatitis score was detected. Levels of ICAM-1, VCAM-1 and PECAM-1 in blood increased with intensifying of hepatic fibrotic changes and were maximal in severe fibrosis. Positive correlation of ICAM-1, VCAM-1 and PECAM-1 with fibrosis score was registered. Conclusion. Definition of adhesion molecules profile in nonalcoholic fatty liver disease allows to ascertain expressiveness of morphological changes and to stratify patients on groups with various morphological activity and liver fibrosis.

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POSITIVE CORRELATION OF THE LEVEL OF MOLECULES OF SUPERFAMILY IMMUNOGLOBULINS ICAM-1, VCAM-1 AND PECAM-1 WITH THE INDEX OF FIBROSIS IN NONALCOHOLIC FATTY LIVER DISEASE. Experimental and Clinical Gastroenterology Journal. 2017;138(02):45-51
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1. I. M. Sechenov First Moscow State Medical University (Moscow, Russian Federation)
2. Federal Research and Clinical Centre of Physical-Chemical Medicine (Moscow, Russian Federation)

Keywords:chronic hepatitis C,cepeginterferon alpha 2b,simeprevir,liver elastometry,recombinant HCV RF1 2k / 1b

Abstract:The features of the application of pegylated interferon - Сepeginterferon alfa2b (cepeg-IFN) on the results of treatment of 20 patients with chronic hepatitis C in outpatient practice. The analysis of the clinical, biochemical, virological data and transient liver elastometry on the background of antiviral therapy with cepeg-IFN. Based on these data is justified is not the worst in comparison with foreign analogues the efficacy and safety of the original domestic product for the treatment of patients with chronic hepatitis C, not previously treated with antiviral therapy, without a high degree of fibrosis or cirrhosis. Demonstrated clinical example of treatment failure associated with infection with a recombinant virus 2k1b and proposes an approach to the diagnosis of this variant infection

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THE EFFI CACY AND SAFETY OF COMBINATION THERAPY OF CHRONIC HEPATITIS C WITH CEPEGINTERFERON ALPHA 2B, REBETOL AND SIMEPREVIR. Experimental and Clinical Gastroenterology Journal. 2017;138(02):52-55
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1. North-Western State Medical University of Mechnikov (St. Petersburg, Russian Federation)

Keywords:chronic hepatitis,regenerative therapy,lipid metabolism,non-alcoholic fatty liver disease

Abstract:Chronic hepatitis is a common socially significant pathology in the world. One of the manifestations of chronic hepatitis B is a violation of lipid metabolism, affecting the course and progression of the underlying disease. Despite holding a large number of studies on the correction of lipid status in patients with chronic hepatitis, treatment of lipid disorders problem remains urgent. In this regard, the aim of our study was to evaluate the effect of combination therapy with the mononuclear fraction of blood compared with standard therapy on the dynamics of lipid metabolism in patients with chronic hepatitis.

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Full text is published :
THE MONONUCLEAR FRACTION OF BLOOD REGENERATIVE THERAPY OF LIPID METABOLISM IN CHRONIC HEPATITIS. Experimental and Clinical Gastroenterology Journal. 2017;138(02):56-61
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1. Astrakhan State Medical University (Astrakhan, Russian Federation)

Keywords:chronic hepatitis,liver cirrhosis,tumor necrosis factor,soluble receptors of tumor necrosis factor II type

Abstract:The Aim was to investigate of clinical and diagnostic value of change of concentration of tumor necrosis factor (TNF) and also soluble receptors II type of tumor necrosis factor (sTNF-RII) in chronic hepatitis (CH) and liver cirrhosis (LC). Material and methods. 65 CH and 64 LC patients and 25 healthy volunteers were included in the investigation. TNF and sTNF-RII concentrations were assessed by the ELISA method. Results. The average TNF level in CH and LC was authentically (p<0,05) increased in comparison with the donors (84.12±10.92 IU/ml and 138.14±19.98 IU/ml cons 23.54±6.02 IU/ml). The sTNF-RII concentration in CH and LC was significantly (p<0,05) increased in comparison with the norm (in CH 7.33±0.32 IU/ml, in LC 13.15±2.19 IU/ml and in control 3.54±0.39 IU/ml). The TNF and sTNF-RII levels were significantly (p<0,05) increased in viral CH and LC in comparison with the alcoholic etiology and norm. The TNF and sTNF-RII increasing associated with the activity of inflammation and severity of LC class on the Child-Pugh score.

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TUMOR NECROSIS FACTOR AND ITS SOLUBLE RECEPTORS II TYPE IN CHRONIC HEPATITIS AND LIVER CIRRHOSIS. Experimental and Clinical Gastroenterology Journal. 2017;138(02):62-66
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1. I. M. Sechenov First Moscow State Medical University (Moscow, Russian Federation)

Keywords:gastroesophageal reflux disease,non-erosive and erosive form,refractory form,nitric oxide synthase,endothelin-1,quality of life,the type of attitude to the disease

Abstract:Revealed clinical and psycho-physical manifestations, especially the pathogenesis, endoscopic and morphological pattern of mucosal pathology Gastroesophageal Zone in elderly patients with erosive and non-erosive form of gastroesophageal reflux disease. A total of 226 patients studied nosology. Applied clinical, endoscopic, morphological, immunohistochemical methods. Increasing the number and functional activity of the stomach and esophagus APUD cell producing nitric oxide synthase and endothelin-1 in patients in comparison with comparison groups, suggests their main pathogenic factor of the disease. Cell hyperplasia cells secreting nitric oxide synthase and endothelin-1, more than twice, there is the formation of refractory form of the disease.

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INCREASED FUNCTIONAL ACTIVITY OF APUD CELL OF THE ESOPHAGUS AND THE STOMACH AT THE GASTROESOPHAGEAL REFL UX IN THE ELDERLY. Experimental and Clinical Gastroenterology Journal. 2017;138(02):67-70
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1. North-Western Medical University named after I. I. Mechnikov (St. Petersburg, Russian Federation)
2. St.-Petersburg State Medical University named after I. P. Pavlov (St. Petersburg, Russian Federation)

Keywords:lung cancer,chemotherapy,gastrointestinal complaints

Abstract:Chemotherapy, used in patients with oncological diseases, leads to damage of a mucous membrane of gastrointestinal tract. 60 % of patients treated by chemotherapy have stools disorders. The article presents the data of the study of the severity of gastrointestinal complaints in patients with lung cancer, chemotherapy, the nature of the influence appointed in the schemes of the treatment of lung cancer anticancer drugs, shows the possibilities of correction of the revealed violations. Using of probiotics in these patients leads to decrease of gastrointestinal complains.

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CORRECTION OF DIGESTIVE DISORDERS BY PROBIOTICS IN LUNG CANCER PATIENTS WITH CHEMOTHERAPY. Experimental and Clinical Gastroenterology Journal. 2017;138(02):71-76
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1. Saratov State Medical University of V. I. Razumovsky (Saratov, Russian Federation)

Keywords:Acute intestinal infections,the treatment of acute intestinal infections,succinate-containing drugs,Reamberinpharmacoeconomic efficiency

Abstract:The aim of the research: the study of features of clinical course of acute intestinal infections (AII) on the background of coronary heart disease (CHD), diabetes (D), mental and behavioral disorders on the background of alcohol consumption (AC); development of pathogenetic therapy for these comorbid conditions by means of using succinate-containing drugs. Materials and Methods: 197 patients with AII (without associated diseases, and with CHD, D, AC) were examined in dynamics. The patients received conventional infusion therapy or 1,5 % solution of Reamberin at 10 mg per 1 kg of body weight. Pharmacoeconomic efficiency of using Reamberin was calculated. Results: Associated pathology determines more severe course of AII and possibility of complications, including decompensation of chronic disease. Introduction of Reamberin in the infusion therapy for patients with AII enabled proved decrease in the number of existing symptoms in all groups by the second day of treatment, as well as decrease in the persistence of the main symptoms of AII. The absence of cases of decompensation of chronic disease in patients receiving Reamberin was noted, in cases of their presence on the background of traditional therapy. Specific economy as a result of using Reamberin in the complex therapy of AII was 23383,5 rubles mainly due to the reduction of the duration of the disease and more rapid vocational rehabilitation. Conclusion: The presence of comorbid pathology affects the typical manifestations of AII, which requires optimization of therapy. The findings show the ability of Reamberin to influence the clinical course of AII, including in cases with associated diseases, by reducing the persistence of the main symptoms of the disease as well as the number of complications associated with decompensation of chronic conditions. High cost-effectiveness of using Reamberin in the treatment of AII, along with a proven positive clinical effect, is an important argument in favor of the widespread use of the succinate-containing drugs in clinical practice.

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REAMBERIN IN THE COMPLEX THERAPY OF ACUTE INTESTINAL INFECTIONS. Experimental and Clinical Gastroenterology Journal. 2017;138(02):77-85
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