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    1. First Saint Petersburg I. P. Pavlov State Medical University (St. Petersburg, Russian Federation)

    Keywords:hiatal hernia,diagnosis of hiatal hernia,surgical treatment of hiatal hernia

    Abstract:Hiatal hernia is one of the most common variants of anatomical dislocation of the abdominal cavity elements. The diagnosis of this condition is based on the results of endoscopic and radiologic investigations. Indications for surgical treatment of hiatal hernias are resistance of gastroesophageal reflux symptoms for conservative management and the risk of its infringement. To increase the effectiveness of surgical interventions, prosthetic materials are used to correct of hiatal hole. The type of antireflux reconstruction depends on the gastroesophageal reflux severity and esophageal motility. Good long-term results of surgical treatment of hiatal hernias are found in 75-85 % of cases.

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      3. Granderath F., Kamolz T., Pointner R. Gastroesophageal reflux disease // Springer-Verlag. - Wien., 2006. - 320 p.
      4. Василевский Д., Кулагин В. Хирургическое лечение гастроэзофагеальной рефлюксной болезни (под ред. С. Ф. Багненко) // М.: СИМК, 2015. - 216 с.
      5. Broeders J. Laparoscopic antireflux surgery indications, techniques and physiological effects // Gildeprint Drukkerijen. - Netherlands., 2011. - 350 p.
      6. Katz P., Gerson L., Vela M. Guidelines for the diagnosis and management of gastroesophageal reflux disease // Am. J. Gastroenterol. - 2013. - Vol. 108. - P. 308-328.
      7. Kohn G., Price R., DeMeester S., et al. Guidelines for the management of hiatal hernia // Surg. Endosc. - 2013. - P. 1-42.
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      9. Fei L., del Genio G., Rossetti G., et al. Hiatal hernia recurrence: surgical complication or disease? Electron microscope findings of the diaphragmatic pillars // J. Gastrointest. Surg. - 2009. - Vol. 13. - P. 459-464.
      10. Frantzides C., Carlson M., Loizides S. et al. Hiatal hernia repair with mesh: a survey of SAGES members // Surg. Endosc. - 2010. - Vol. 24. - P. 1017-1024.
      11. Granderath F., Granderath U., Pointner R. Laparoscopic revisional fundoplication with circular hiatal mesh prosthesis: the long-term results // W. J. Surg. - 2008. - Vol. 32. - P. 999-1007.
      12. Pointner R., Granderath F. Hiatus hernia and recurrence: the Achilles heel of antireflux surgery? // Chirurg. - 2008. - Vol. 79. - P. 974-981.

    Full text is published :
    Vasilevskiy D.I., Smirnov A.A. DIAGNOSIS AND TREATMENT OF HIATAL HERNIAS. Experimental and Clinical Gastroenterology Journal. 2017;140(04):92-94
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    1. Multidisciplinary clinical and diagnostic center “Avicenna” (Simferopol, Russian Federation)

    Abstract:The aim was to study the quality of oral colon preparation for colonoscopy with an individual approach, comparing full volume 4 l of glycols with polyethylene glycols (PEG) of a reduced 2 l volume (MOVIPREP®) under conditions of risk factors for poor bowel preparation. Conclusion: MOVIPREP® has a one-step morning dosage regimen and may be the drug of choice for patients for whom preparation on the day of a colonoscopy is important. MOVIPREP® was noted by patients as more comfortable due to taste, smaller volume, fewer bowel movements, which allows reduction of the time interval between the end of preparation and the holding of a colonoscopy. Keywords: colonoscopy, preparation for colonoscopy, colorectal cancer screening, oral colon cleansers, low-fiber diet, MOVIPREP®, PEG 4 liters

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    Full text is published :
    Korneev A.A. PREPARING FOR A COLONOSCOPY. CRIMEAN EXPERIENCE. Experimental and Clinical Gastroenterology Journal. 2017;140(04):95-102
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    1. Moscow state medical and dentistry University n.a. A.I. Evdokimov (Moscow, Russian Federation)

    Keywords:Helicobacter pylori, eradication therapy, resistance

    Abstract:In accordance with modern consensus recommendations, the choice of eradication therapy (ET) should be based on information about the prevalence of resistant H. pylori strains to clarithromycin and metronidozole (including dual resistance to these drugs) in a particular region of the world. In regions with a low level of clarithromycin resistance (<15%), classical triple therapy is considered as first-line therapy and can be administered empirically. Bismuth-containing quadrotherapy is an alternative. In regions with high resistance to clarithromycin (> 15%), bismuth-containing quadrotherapy or quadrotherapy without bismuth preparations (“simultaneous” therapy) is recommended. In regions with a high double resistance rate, both clarithromycin and metronidazole, bismuth-containing quadrotherapy is recommended as first-line ET. Among the optimization methods that can significantly increase the effectiveness of ET can be distinguished: the addition of bismuth drug in the ET regimen (by 10–20%), the use of rebathide in the ET regimen (by 11.9%), the use of adjuvant therapy using probiotics 8.1–14.1%) and the use of double doses of proton pump inhibitors (by 8%), as well as an increase in patient compliance, timely monitoring of the effectiveness of therapy and the use of adequate doses of drugs with proven effectiveness. Significant reduction in the frequency of adverse events against the background of ongoing ET is achieved only using adjuvant therapy with probiotics.

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    1. First Moscow State Medical Univercity (Moscow, Russian Federation)
    2. Pirogov Russian National Research Medical University (Moscow, Russian Federation)
    3. FSAI The Scientific Center of Children’s Health (Moscow, Russian Federation)
    4. Morozov Pediatric Clinical Hospital of Moscow Healthcare Department (Moscow, Russian Federation)
    5. Moscow Clinical and Research Center (Moscow, Russian Federation)
    6. Children’s Clinical and Research Institute of Emergency surgery and Trauma (Moscow, Russian Federation)

    Keywords:children,confocal laser endomicroscopy,optical biopsy,histology,gastric,duodenum

    Abstract:Aim: to analyze the value of confocal laser endomicroscopy in diagnostics of gastric and duodenal mucosa changes in children. Patients and Methods: In the current study a total of 116 children aged from 3 to 18 years old undergo conventional endoscopy with confocal laser endomicroscopy supplemented with mucosal biopsy followed by traditional histology in the period from 2011 until 2014. To determine the prognostic value of the of probe based CLE in the evaluation of normal and pathological changes of the gastric and duodenal mucosa a comparison of results of optical biopsy with the data obtained during the standard histological examination were performed. Results: After results of probe-based CLE and traditional histology were comprised optical biopsy showed 83,7 %sensitivity and 87,5 %specificity to gastritis with Spearmen correlation 0,67 (р=0,001); 86,7 % sensitivity and 81,8 %specificity to duodenitis with Spearmen correlation 0,67(р=0,001). Conclusion: Confocal endomicroscopy may become one of the leading methods in pediatric gastroenterology since it allows the endoscopists to inspect the mucosa at the cellular level during the endoscopic procedure and can help to eliminate the mismatch between histological and endoscopic diagnosis.

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    Shavrov A.A., Volynets G.V., Khavkin A.I., Morozov D.A. et al. CONFOCAL LASER ENDOMICROSCOPY FOR DIAGNOSIS OF GASTRIC AND DUODENAL MUCOSAL CHANGES IN CHILDREN. Experimental and Clinical Gastroenterology Journal. 2017;140(04):111-116
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