1. Research Institute of Internal and Preventive Medicine - Banch of the Institute of Cytology and Genetics RAN (Novosibirsk, Russian Federation)
2. Novosibirsk State Medical University (Novosibirsk, Russian Federation)

Keywords:idiopathic hyperprolactinemia,intrahepatic cholestasis,clinical case

Abstract:A clinical case of a female patient 25 years old with intrahepatic cholestasis and idiopathic hyperprolactinemia diagnosed at age 17 years is presented. Intrahepatic cholestasis manifested for the first time in the third trimester of pregnancy in the classic version, and regressed immediately after delivery. However, within 3 months after birth and established lactation the clinical and laboratory signs of cholestasis reappeared. After exclusion of organic liver and biliary tract diseases, the therapy with UDCA was initiated but without clinical and laboratory improvement. Due to lack of the effect of standard treatment the decision was made about medical suppression of lactation with cabergoline. After suppression of lactation all signs of cholestasis disappeared. Afterwards episodes of intrahepatic cholestasis repeated again with typical clinical and laboratory manifestations. They were treated by elevated doses of cabergoline. The observation time was 12 months.

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Full text is published :
Voevoda S.M., Rymar O.D., Kurilovich S.A. SYNDROME OF RECURRENT INTRAHEPATIC CHOLESTASIS IN A FEMALE PATIENT WITH IDIOPATHIC HYPERPROLACTINEMIA. Experimental and Clinical Gastroenterology Journal. 2017;145(09):116-120
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