1. State Educational Institution of Higher Professional Education “Kuban State Medical University” Ministry of Health Care of the Russian Federation (Krasnodar, Russian Federation)
2. Federal State-funded Educational Institution of Higher Professional Education “Kuban State Agrarian University” Ministry of Agriculture of the Russian Federation (Krasnodar, Russian Federation)

Keywords:vascular liver isolation,hepatocytolysis,endogenous intoxication,antioxidant system,oxidative stress

Abstract:Object. To study the temporal dependence of metabolic indicators experimentally by simulating the liver ischemia in rats in conditions of the partial vascular liver isolation. Materials and methods. The partial vascular liver isolation was simulated in nonlinear male rats by means of cross-clamping of the hepatoduodenal ligament for 10, 15 and 20 minutes. The markers of cytolysis, the prooxidant-antioxidant system and the functional detoxification system were detected on the local level as well as on the systemic one. Results. The gradual increase of hepatocytolysis, endogenous intoxication and the intensity of free-radical processes were detected as well as the activation of bodily compensatory systems within 10-15 minutes and their further emaciation by the 20^th minute of ischemia. Conclusion. The demonstrated data open the prospects to the metabolic correction of ischemic and reperfusive complications; they also may be useful by forming the conception of reasonable temporal limitation of the vascular liver isolation.

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Full text is published :
THE TEMPORAL DEPENDENCE OF METABOLIC INDICATORS BY THE PARTIAL VASCULAR LIVER ISOLATION IN CONDITIONS OF EXPERIMENT. Experimental and Clinical Gastroenterology Journal. 2017;145(09):82-86
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