1. State budget institution of Higher Professional Education “Omsk State Medical University”, the Ministry of Health of the Russian Federation (Omsk, Russian Federation)
2. State Educational Institution of Higher Professional Education “Novosibirsk State Medical University”, the Ministry of Health of the Russian Federation (Novosibirsk, Russian Federation)

Keywords:gluten sensitivity is not associated with celiac disease (NCGS),gluten-related diseases,IBS-like symptoms,amylase- trypsin inhibitors (ATIs),antigliadinantibodies of class IgG (IgG-AGA),gluten-free diet,HLADQ2 and DQ8 genotypes

Abstract:Rising incidence of different variants of gluten intolerance associated with changes in eating behaviorin many countries, changes in the technology of growing and processing crops, new culinary technologies. Until recently, celiac disease, dermatitis herpetiformis and wheat allergy were the only known disease with a proven role of gluten in their pathogenesis. Non-celiac gluten sensitivity (NCGS)- a new syndrome of intolerance to gluten. This pathology can be suspected in patients with persistent intestinal and extra-intestinal symptoms clearly associated with the intake of foods containing gluten, the absence of serological markers of celiac disease or suspected allergy to wheat. The paper presents the current data on the epidemiology, etiology and pathogenesis, clinical features and diagnosis NCGS.

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Full text is published :
Osipenko M.F., Zayakina N.V., Krolevec T.S. THE MANY FACES OF THE PROBLEM OF INTOLERANCE TO GLUTEN. Experimental and Clinical Gastroenterology Journal. 2017;145(09):4-9
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