1. Research Institute of Internal and Preventive Medicine - Branch of Institute of Cytology and Genetics SB RAN” (Novosibirsk, Russian Federation)
2. Novosibirsk State Medical University (Novosibirsk, Russian Federation)

Keywords: Atrophic gastritis,gastric cancer,pepsinogen I,PGI/PGII ratio,IL-1β polymorphism

Abstract:Background: Serum biomarkers of atrophic gastritis (pepsinogen I (PGI) and PGI/PGII ratio) are important for gastric cancer (GC) risk stratification. According to a number of researches IL1В gene polymorphisms are associated with risk of GC. The aim: to study the association of IL1В gene promoter polymorphism (-511C/T (rs16944) with GC in the prospective “case-control” study (8 years follow up). Materials and methods: the base of biomaterials received in 2003-2005 in population selection of residents of Novosibirsk within the international HAPIEE project (DNA samples and serums were stored at - 70⁰C) were compared with data of the population register of GC (in 2012). For each case of GC, an appropriate control case was selected at the ratio 1:2 matching the area of residence, sex and age. Finally 156 serum samples (52 - GC group and 104 - control) were available for the analysis using a panel of serum biomarkers “Gastropanel” (Biohit, Finland) and 141 DNA samples (49 - GC group and 92 - control) were genotyped according to the published method. Results: the frequency of T/T genotype of the IL1В was found significantly higher in the GC group (16.3 %) compared with the control (5.4 %) (p=0.03). The T/T genotype was associated with significantly increased risks of GC compared with the C/C genotype (OR=3.4; СI: 1.0-11.0, р=0.03). It was shown that rare T allele carriers have increased risk GC development (OR=1.69; CI: 1.01-2.81, р=0.04) in comparison with wild C allele carriers (OR=0.59; CI: 0.36-0.99, р=0.04). The mean level of PGI and PGI/II ratio in persons with T/T genotype were significantly lower in GC group (41.3 ±31.8 µg/l and 4.1±2.9 versus 131.0±57.2 µg/l and 7.0±2.8; p=0.0001 and p=0.05 respectively). Conclusion: IL1В polymorphism (rs16944) is associated with an increased risk of GC in the population of Western Siberia and can be discussed for inclusion in the GC riskometer.

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Full text is published :
Belkovets A.V., Kurilovich S.A., Maksimov V.N., Ragino Yu.I. et al. IL1В POLYMORPHISM IS ASSOCIATED WITH AN INCREASED RISK OF GASTRIC CANCER IN THE POPULATION OF WESTERN SIBERIA. Experimental and Clinical Gastroenterology Journal. 2017;145(09):10-17
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1. Federal State budgetary educational institution of higher professional education “Novosibirsk state medical University” Ministry of healthcare of the Russian Federation (Novosibirsk, Russian Federation)
2. Research Institutе of Internal and Preventive Medicine” -Branch of the Federal State Budget Scientific Institution “The Federal Research Center Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences (Novosibirsk, Russian Federation)

Keywords: Non-alcoholic fatty liver disease,the polymorphism of alleles C 282Y and H63D of HFE gene,porphyrin metabolism,HFE,H63D,282Y

Abstract:Тhe purpose of the study. The determination of the frequency of polymorphism alleles C 282Y and H63D of the HFE gene in nonalcoholic fatty liver disease (NAFLD) in comparison to individuals from the General population and to identify the peculiarities in the metabolism of porphyrins. Materials and methods. Molecular genetic examination was performed in 454 people. We evaluated the frequency of polymorphism alleles C 282Y and H63D of the HFE gene in patients with NAFLD (major group 112) and compared with the results obtained in the examination of persons General population (comparison group, 342 people). Patients with NAFLD were determined excretory profile of indicators of porphyrin exchange. Results. Polymorphism of the alleles C 282Y and H63D of the HFE gene in patients with NAFLD and in patients the General population is recorded with the same frequency, respectively, at 32.1 % and 33.9 % of cases. In both groups, was often detected polymorphism for alleles С282У, respectively, 26.8 % and 28.1 % of cases. Disorders of porphyrin metabolism diagnosed in 77 (68,8 %) patients had NAFLD. Comparative analysis of detected disorders of porphyrin metabolism in patients with the identified polymorphisms C 282Y and H63D in HFE gene and without it did not reveal fundamental differences in the qualitative characteristics. Patients were recorded with identical violations. In patients with existing polymorphisms C 282Y and H63D in the HFE gene, the frequency of violations and their degree of severity were significantly higher (p < 0,05-0,001). Conclusion. The metabolism of porphyrins can be measured very sensitive “indicator” responsive to the diverse non-specific abnormalities under the wide range of metabolic disorders, including genetic disorders. Detection of the C 282Y and H63D polymorphisms of the HFE gene in combination with disorders of porphyrin metabolism allows us to consider such patients as a risk group who have not excluded an increased risk of formation of liver fibrosis.

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Full text is published :
Kondratova M.A., Kuimov A.D., Maksimov V.N., Aleschkina A.V. et al. THE FREQUENCY OF HFE GENE POLYMORPHISM IN PATIENTS WITH NONALCOHOLIC LIVER DISEASE AND IN PERSONS OF THE GENERAL POPULATION. FEATURES OF METABOLIC DISORDERS. Experimental and Clinical Gastroenterology Journal. 2017;145(09):18-24
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1. Novosibirsk State Medical University” (Novosibirsk, Russian Federation)
2. Institute of Chemical Biology and Fundamental Medicine of the SB RAS (Novosibirsk, Russian Federation)
3. City Infectious Clinical Hospital No.1” (Novosibirsk, Russian Federation)

Keywords: acute viral gastroenteritis,norovirus,rotavirus,astrovirus,polymerase chain reaction

Abstract:The aim of this study was to determine the frequency and the clinical and laboratory features of norovirus acute gastroenteritis (AGE) in adult hospitalized patients, the residents of city Novosibirsk. Materials and methods: A total of 1047 patients aged 15 to 89 years who were hospitalized with AGE from January 2016 to April 2017 with no evidence of immunosuppression were examined. Together with conventional diagnostic methods, the polymerase chain reaction method with a set of original specific primers was also used to investigate feces for the presence of group A and group C rotaviruses, norovirus genogroup II (HNoV GII) and astroviruses. Results: Viral etiology was determined in 20.8 % of patients with AGE. HNoV GII was the dominant (13.6 %), followed by group A rotavirus (5.3 %) and astroviruses (2.0 %). HNoV GII dominance was observed in most months of the study period. For HNoV GII enteritis, a high incidence (p<0.05) of moderate fever and lymphocytosis is established in comparison with other AGE. Conclusion: The established frequency of viral AGE in adults shows the need to develop and implement in clinical practice universal test systems for detection of the most common viral pathogens. The predominance of HNoV GII in the structure of viral diarrhea aims further research on the genetic diversity of the isolates circulating in the Novosibirsk region.

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Krasnova E.I., Kapustin D.V., Khokhlova N.I., Zhirakovskaia E.V. et al. ACUTE NOROVIRUS GASTROENTERITIS IN ADULTS. Experimental and Clinical Gastroenterology Journal. 2017;145(09):25-29
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1. «Novosibirsk State Medical University», Ministry of Health of Russia (Novosibirsk, Russian Federation)

Keywords: Crohn’s disease,ulcerative colitis,small intestinal bacterial overgrowth syndrome,quality of life

Abstract:Patients with inflammatory bowel disease (IBD) are characterized by chronic recurrent course, frequent attacks, the presence of extraintestinal manifestations and the occurrence of complications, which leads to a decrease in the quality of life. One of the concomitant conditions in patients with IBD is the small intestinal bacterial overgrowth syndrome (SIBO), which has common clinical manifestations. There is practically no research on the effect of concomitant SIBO in patients with IBD on the quality of life (QOL). Therefore, the study of QOL in patients with IBD with SIBO is an important task for optimizing treatment. Purpose: to study the quality of life in patients with IBD, depending on the presence of SIBO. Material and methods of the study: patients from the registry of inflammatory bowel diseases in Novosibirsk who underwent a hydrogen respiratory test (HBT) on the device «Gastro+». The QOL indicators were determined using the Russian version of the SF-36 and IBDQ questionnaire. Results: in 152 patients with IBD, in whom HBT was carried out, the prevalence of SIBO was 48.0 % (with ulcerative colitis - 45.7 %, with Crohn’s disease - 50.7 %). In the scales of the SF-36 and IBDQ questionnaire significant decrease in QOL values was revealed in patients with IBD with positive results of HBT in comparison with patients with negative results of HBT. After a 2-week course of rifaximin intake, values increased in almost all scales of the SF-36 and IBDQ questionnaires. Conclusion: The obtained data confirm the necessity of correction of SIBO as an independent clinical task that significantly affects QOL of patients with IBD.

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Kulygina Yu.A., Osipenko M.F. INDICATORS OF LIFE QUALITY IN PATIENTS WITH INFLAMMATORY DISEASES OF THE SMALL INTESTINAL BACTERIAL OVERGROWTH SYNDROME (ON THE DATA OF THE NOVOSIBIRSK REGISTER). Experimental and Clinical Gastroenterology Journal. 2017;145(09):30-34
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1. Novosibirsk State Medical University (Novosibirsk, Russian Federation)
2. IIPM - Branch of IC&G SB RA (Novosibirsk, Russian Federation)

Keywords: Hepatitis C virus,sexual transmission,epidemiology of hepatitis C,risk factors

Abstract:Data for the last and a half decade concerning the infection with hepatitis C virus in the population of Novosibirsk are presented. 173 patients infected with hepatitis C were questioned to find out the possibility of sexual transmission of the disease. Among the examined patients, 6.4 % were infected due to non-preserved sexual intercourse with partners using intravenous drugs. The risk factors have been estimated. The clinical example is given.

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Full text is published :
Khryanin A.A., Nemchaninova O.B., Lykova S.G., Reshetnikova T.B. et al. EPIDEMIOLOGY OF HEPATITIS C VIRUS AND SEXUAL TRANSMISSION. Experimental and Clinical Gastroenterology Journal. 2017;145(09):35-40
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1. Novosibirsk State Medical University (Novosibirsk, Russian Federation)

Abstract:Mycotic pathology was diagnosed clinically and confirmed with laboratory methods at 77,1 % from 368 patients with various forms chronic diffuse diseases of a liver, at the same time 817 cases of various nosological forms of fungic diseases are taped. Often mycoses proceeded is widespread and is combined, and also had a series of clinical features not inherent to them. The submitted data can be used both by gastroenterologists, and dermatologists.

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Full text is published :
Pozdnyakova O.N., Nemchaninova O.B., Lykova S.G., Reshetnikova T.B. et al. CLINICAL FEATURES OF FUNGAL INFECTIONS IN PATIENTS WITH CHRONIC DIFFUSE LIVER DISEASES. Experimental and Clinical Gastroenterology Journal. 2017;145(09):41-44
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1. Novosibirsk State Medical University (Novosibirsk, Russian Federation)

Keywords:Inflammatory bowel diseases,ulcerous colitis,Crohn’s disease,metabolic syndrome,arterial hypertension,obesity,steatohepatosis,GERD,gallstones,comorbid diseases

Abstract:The purpose of the review: to observe prevalence and features of such comorbidities as gastroesophageal reflux disease, nonalcoholic fatty liver disease, metabolic syndrome and it’s components in patients with inflammatory bowel diseases (IBD). Methods: as literature sources databases Pubmed and Medscape were used, also data from monographies and Russian and foreign journal publications was included. Results: Higher frequency of steatohepatosis in IBD patients and higher frequency of gallstones in patients with Crohn’s disease (CD) are demonstrated. A risk factors of this comorbid diseases are described. Also lower frequency of arterial hypertension among IBD patients was shown. Higher frequency of metabolic syndrome in patients with ulcerous colitis vs. patients with CD was demonstrated. Higher severity of gastroesophageal reflux symptoms in IBD patients vs. patients with irritable bowel syndrome was shown. Article describes possible pathophysiological substrate of this clinical features. Conclusion. Frequency and clinical features of described comorbidities were analyzed. Literature analysis showed a lack of data about clinical features of gastroesophageal reflux disease and metabolic syndrome in IBD patients at this moment, so an additional studies on this subject are necessary.

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Full text is published :
Krasner Ya.A., Osipenko M.F., Mamontova E.P., Bikbulatova E.A. INCIDENCE AND FEATURES OF CLINICAL COURSE OF UPPER GASTROINTESTINAL TRACT DISEASES AND METABOLIC SYNDROME IN IBD PATIENTS. Experimental and Clinical Gastroenterology Journal. 2017;145(09):45-51
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1. Novosibirsk State Medical University (Novosibirsk, Russian Federation)

Keywords:nutritional status,adipokines,arterial hypertension,chronic obstructive pulmonary disease,comorbidity

Abstract:The state of nutritional status was studied in 161 patients with arterial hypertension (AH) in combination with chronic obstructive pulmonary disease (COPD), divided in three groups: 1st (54) - with AH, 2nd (52) - with COPD, 3rd (55) - with AH in combination with COPD. Based on the assessment of actual nutrition, anthropometric survey data, lipid, protein and carbohydrate metabolism, the level of adipokines and cytokines, it was determined that the nutritional features of patients with AH in combination with COPD are: high values of the index waist circumference / circumference of hips, increased fat mass and extracellular fluid, decrease in muscle component of the body, increased levels of total cholesterol and its atherogenic fractions, reducing the concentration of prealbumin, increased levels of leptin and resistin on the background of decreased adiponectin and leptin-binding receptor and increasing concentrations of the studied cytokines IL-1, IL-6, IL-18 and TNF-α. It was found that patients with AH in combination with COPD index waist circumference / circumference of hips for assessment of nutritional status has a greater diagnostic value than body mass index. Timely detection and correction of nutritional disorders will improve the effectiveness of treatment of patients.

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Full text is published :
Gerasimenko O.N., Drobyshev V.A., Shpagin I.S., Sukhoterina N.A. et al. FEATURES OF NUTRITIONAL STATUS IN PATIENTS WITH ARTERIAL HYPERTENSION IN COMBINATION WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE. Experimental and Clinical Gastroenterology Journal. 2017;145(09):52-55
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1. Novosibirsk State Medical University (Novosibirsk, Russian Federation)

Keywords:diabetes mellitus type 2,dyspepsia,functional dyspepsia,autonomic function,anxiety,quality of life

Abstract:The research of 75 patients with diabetes mellitus type 2 and 33 patients with functional dyspepsia was conducted. The aim was to study relationship between dyspepsia and the level of autonomic function, general anxiety and quality of life in patients with diabetes mellitus type 2. The level of autonomic function was higher in patients with diabetes mellitus type 2 in the presence of dyspepsia, but did not reach indexes in patients with functional dyspepsia. The level of general anxiety in patients with diabetes mellitus type 2 was increased, did not depend on the presence of dyspepsia and did not differ from those with functional dyspepsia. Dyspepsia syndrome aggravated the reduced quality of life in patients with diabetes mellitus type 2, and its level was worser, than in patients with functional dyspepsia. Statistical analysis demonstrated negative correlation between the quality of life and the level of autonomic function and anxiety indexes.

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Full text is published :
Zhuk E.A., Medvedeva O.V., Shakaliter Yu.D., Voroncova E.S. DYSPEPSIA SYNDROME, LEVELS OF AUTONOMIC FUNCTION, ANXIETY AND QUALITY OF LIFE IN PATIENTS WITH DIABETES MELLITUS TYPE 2. Experimental and Clinical Gastroenterology Journal. 2017;145(09):56-59
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1. Novosibirsk state medical University (Novosibirsk, Russian Federation)

Keywords:gastrointestinal tract,tumors,precancerous conditions,inflammatory diseases,biopsy

Abstract:The aim of the study was to study the frequency, prevalence and nosological structure of pre-tumoral and tumor processes in the gastrointestinal tract on the basis of morphological study data. Materials and metods: 1294 specimens of biopsy specimens from the stomach and intestines were studied for the period 2014-2016. Results. Of the 1,294 specimens examined, the stomach accounted for 58 % of the small and large intestine - 42 %. Of 750 stomach biopsies, inflammatory diseases were detected in 61.7 %, hyperplastic processes in 19.6 %, tumors in 10 %, biopsy from gastroanastomoses - 7.73 %. Of the 544 biopsies of the intestine, 20.2 % of cases of small intestinal disease, 78.2 % of the large intestine, and 1.6 % of intestinal anastomoses. In biopsies of the small intestine, inflammatory processes prevailed (71.8 %), hyperplastic processes - 18.2 %, tumors - 6.4 %. When studying the nosological structure of the lesion of the large intestine: inflammatory diseases of the large intestine - 24.9 %, hyperplastic processes -17.5 %, tumors - 48.1 %, other processes -7.4 % and biopsies from intestinal anastomoses -2.1 %. Conclusions. Inflammatory diseases prevailed in the structure of pathological processes of the stomach (61.73 %) and the small intestine (71.8 %). The most frequent localization of tumors of the gastrointestinal tract was the large intestine (48.1 %), and the most common histological variant of malignant tumors was adenocarcinoma (94 %). Tumors of the stomach accounted for 10 % of the total number of pathological processes, and among the histological variants the most common was adenocarcinoma (64.1 %).

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Full text is published :
Nadeev A.P., Kozaev M.A., Porotnikova E.V., Sadykova A.M. NOSOLOGICAL STRUCTURE OF THE GASTRO-INTESTINAL TRACT DISEASES ACCORDING TO BIOPSY STUDIES. Experimental and Clinical Gastroenterology Journal. 2017;145(09):60-64
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