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    1. First MSMU n. a. I. M. Sechenov

    Keywords:diffuse family polyposis,adenomatous polyposis,colorectal cancer,colonoscopy,autosomal dominant type of inheritance

    Abstract:It was performed the analysis of modern ideas about the features of etiopathogenesis, diagnosis and treatment of diffuse family polyposis. Diffuse family polyposis or familial adenomatous polyposis (FAP) refers to genetically conditioned multi-tumor syndromes, which represent a separate group of diseases characterized by polyps in the gastrointestinal tract and are considered as potentially malignant multifocal process. The most frequent clinical manifestations of pathology and methods of its diagnostics are described, features of monitoring of this category of patients are characterized. The methods of treatment of FAP are considered, while all the revealed colloctal polyps should be removed. The method of choice in this case is endoscopic polypectomy, with their location no more than 5-7 cm from the edge of the anus - transansal resection. The need for early diagnosis and treatment of this category of patients is indicated, while specialists should be informed about extraintestinal benign and malignant manifestations of FAP and associations between them. It was noted that a timely diagnosis of hereditary syndrome in patients with high-risk FAP, as well as dynamic monitoring of them, helps to recognize the presence of a malignant tumor and provides the possibility of sparing treatment in the early stages of the disease.

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    SCLINICAL-DIFFUSE FAMILY POLYPOSIS IN CHILDREN. Experimental and Clinical Gastroenterology Journal. 2018;149(01):61-67
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    1. The Research and Clinical Institute for Pediatrics n. a. Academician Yu. Veltischev of the Pirogov Russian National Research Medical University of the Russian Ministry of Health
    2. SPb Children’s City Polyclinic No. 8, Consultative and Diagnostic Center with a day hospital, Ministry of Health of Russia

    Keywords:thyrogastric syndrome,children,autoimmune gastritis,autoimmune thyroiditis

    Abstract:The term “thyrogastric syndrome” - combined thyroid and stomach damage, defines the association between autoimmune thyroid disease and atrophic gastritis. Today thyrogastric syndrome is considered as a manifestation of polyglandular autoimmune syndrome type IIIb, characterized by Hashimoto’s thyroiditis in combination with one or more endocrine and non-endocrine autoimmune diseases. The incidence of thyrogastric syndrome is high: among patients with autoimmune thyroiditis, 12-40 % of adults and one-third of children have antiparietal antibodies; among patients with atrophic gastritis, Hashimoto’s thyroiditis is diagnosed in 40 % of cases. In this paper we describe general genetic, embryological, immunological and infectious factors, the interaction of which leads to the formation of the disease.

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    Full text is published :
    CLINICAL-INSTRUMENTAL FEATURES OF THE COMPUTED DISEASES OF THE THYROID GLAND AND THE STOMACH IN CHILDREN. Experimental and Clinical Gastroenterology Journal. 2018;149(01):68-73
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    1. N. P. Ogarev National Research Mordovia State University

    Keywords:hemostasis,acute pancreatitis,remaxol,thrombelastography

    Abstract:A clinical and laboratory examination of 60 patients with acute severe pancreatitis divided into two groups was performed: the first (n = 30) patients who received standardized treatment, the second (n = 30) patients who were treated with remaxol: intravenous drip infusions of 400,0/daily for 6 days with a corresponding decrease in total infusion volume. Control (3rd) group - 30 healthy people. It was found, that the inclusion of remaxol in the therapy of the patients in the early stage of the disease leads to significant changes in the state of the coagulation-lytic system. It was noted, that the reliable effect of the remaxol on most of the studied parameters was recorded from the second day, and after four days of the study became near to normal level.

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    THROMBOELASTOGRAPHY IN EVALUATION OF HAEMOSTATIC-CORRECTIVE EFFECTS OF REMAXOL IN ACUTE SEVERE PANCREATITIS. Experimental and Clinical Gastroenterology Journal. 2018;149(01):74-79
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