1. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation, Institute for regenerative medicine (Moscow, Russian Federation)

Keywords: cholelithiasis, cholangiopathy, toll-like receptors, gallstone disease, gallstones

Abstract:It is believed that gallstone formation in the biliary tree is a disease associated with alterations of the normal functioning of the organism, and often accompanied by metabolic dysfunction. Recent scientific data allow us to take a fresh look at the problem by proposing an original hypothesis about gallstone formation as a protective immunological reaction of the biliary three cells aimed to isolate exogenous microorganisms and to stop overexpression of toll-like receptors (TLR). In this paradigm, the cholelithiasis appears to be an autoimmune cholangiopathy, therapy of which is associated with the normalization of the immune status of cholangiocytes and down-regulation of its membrane receptors.

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Full text is published :
Klabukov I. D., Krasilnikova O. A., Lyundup A. V., Dyuzheva T. G. IMMUNOLOGICAL CAUSES OF GALLSTONE DISEASE (ORIGINAL HYPOTHESIS). Experimental and Clinical Gastroenterology Journal. 2018;154(06):134-142
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