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    1. Public budgetary educational institution of higher education “Ogarev Mordovia State University” of Ministry of Education of Russia (Saransk, Russian Federation)

    Keywords: nausea, vomiting, diagnostics, treatment

    Abstract:The article is devoted to the problem of the emetic syndrome. Details are presented etiology, basic variants and diagnostic criteria for the disease. The article focuses on the aspects of treatment of patients with an emetic syndrome.

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    Strokova О. А., Ereminа E. Yu. EMETIC SYNDROME: PRINCIPLES OF DIAGNOSIS AND TREATMENT. Experimental and Clinical Gastroenterology Journal. 2018;154(06):116-121
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    1. Scientific Research Institute of Molecular Biology and Medicine (Bishkek, Kyrgyzstan)
    2. Kyrgyz State Medical Academy named after I. K. Akhunbayev (Bishkek, Kyrgyzstan)
    3. Kyrgyz Russian Slavic University named after the First President of Russia B. N. Yeltsin (Bishkek, Kyrgyzstan)
    4. FSAEI HE First Moscow State Medical University named after I. M. Sechenov (Moscow, Russian Federation)
    5. Family Medicine Center № 7 (Bishkek, Kyrgyzstan)

    Keywords: gut microbiota, dysbiosis, epigenome, regulation

    Abstract:The development and introduction of high-performance molecular genetic methods into practice allowed us, in recent years, to increase our knowledge of the epigenome and microbiome, which shed light on the mechanisms of development of various pathologies, such as cancer, immune-mediated, metabolic and cardiovascular diseases. It was found that the dysbiosis of gut microbiota (GM), which often accompanies these diseases, can affect the epigenetic mechanisms of the regulation of the activity of individual genes either directly through a change in the composition of GM, or indirectly, through changes in metabolites, which are various biologically active substances (short-chain fatty acids, biotin, folic acid and other biologically active molecules). Indeed, correlations between epigenetic mechanisms regulating the activity of host genes, on one hand, and changes in the composition of its gut microbiota or metabolites produced by intestinal microorganisms, on the other, have been established in certain diseases. It served as the basis for assuming that GM can become a diagnostic marker for certain diseases, and that treating the intestinal dysbiosis by transplanting healthy microflora is an effective therapeutic strategy. In this article, we discuss the relationship between dysbiosis of the gut microbiota and the host’s epigenome, as well as the possibility of using the microbiome and epigenome as diagnostic and therapeutic targets.

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    Aitbaev K.A., Murkamilov I.T., Fomin V.V., Murkamilova Zh.A. INFLUENCE OF GUT MICROBIOTA ON EPIGENETICS: MECHANISMS, ROLE IN THE DEVELOPMENT OF DISEASES, DIAGNOSTIC AND THERAPEUTIC POTENTIAL. Experimental and Clinical Gastroenterology Journal. 2018;154(06):122-129
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    1. Peoples’ Friendship University of Russia (Moscow, Russian Federation)
    2. Volgograd State Medical University (Volgograd, Russian Federation)

    Keywords: Oddi’s sphincter, dysfunction, “biliary pain”, “pancreatic pain”, diagnostics, treatment

    Abstract:This article is devoted to the clinical picture, approaches to diagnosis and treatment of Oddi´s sphincter dysfunction.

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    Khalilova U. A., Skvortsov V. V., Lunkov M. V. DIAGNOSIS AND TREATMENT OF ODDI´S SPHINCTER DYSFUNCTION. Experimental and Clinical Gastroenterology Journal. 2018;154(06):130-133
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