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    1. Federal public budgetary educational institution of higher education “Altay State Medical University” of the Ministry of Healthcare of Russia (Barnaul, Russia)

    Keywords: peptide complex, peptic ulcer disease, experimental gastropathy, oxidative stress, cyclooxygenase, antioxidant activity

    Abstract:The aim was to investigate the influence of the peptide complex from pork kidney tissues on indicators of free radical oxidation and the expression of COX-1,2 in experimental Indometacine-induced gastropathy. Materials and methods: There were examined 67 male Wistar rats. Experimental peptic ulcer disease was reached by the injection into the stomach of 60mg/kg Indometacine. The experimental group had got 75mg/kg for 7 days up to the Indometacine injection. The concentration of enzymes COX-1, 2 in blood plasma and gastric homogenate were determined by the method of enzyme immunoassay. The activity of free radical oxidization processes was evaluated by the coloring intensity of the products of the corresponding biochemical reactions. Results: In the experimental group the concentration of COX-2 in the gastric mucosa was reduced by 26.5% comparing to the intact group. Thiobarbituric acid-reactive substances concentration was redused in 2,3 times comparing to the control group. Increased under the effect of indomethacin, the concentrations of superoxide dismutase and glutathione peroxidase were equal the concentrations of healthy rats. Conclusion: The injection of a peptide complex from pork kidney tissues for 7 days is accompanied by reducing of the inflammatory process in the gastric mucosa, as evidenced by a decrease in the concentration of COX-2 in the stomach homogenate, as well as reducing of oxidative damage to gastric cells and strengthening their enzyme antioxidant protection.

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      5. Shcherbatykh A. V., Kulinsky V. I., Bolsheshapov A. A., Sokolova S. V. lipid Peroxidation and antioxidant system in gastric ulcer, duodenal ulcer and postgastrectomy syndromes // Siberian scientific medical journal.. – 2005. – № 3. – P. 9–13.
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      7. Zharikova G. V., Zharikov A. Yu., Kiselev V. I. et al. The influence of peptide complex from the tissues of pig kidneys on the indicators of free radical oxidation in experimental urolithiasis // Siberian scientific medical journal 2017. – Vol. 37, № 2. – P. 17–21
      8. Stepanov Yu. M., Breslavets Yu. S. Dynamics of the content of COX-2 in the mucosa of the stomach and duodenum on the background of medicamentous correction of NSAID-gastropathy. Gastroenterology, 2013, volume 47 No. 1, C36–42
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    Full text is published :
    Lorents S. E., Zharikov A. Yu., Mazko O. N., Makarova O. G. et al. INFLUENCE OF THE PEPTIDE COMPLEX FROM PORK KIDNEYS TISSUES ON INDICATORS OF FREE RADICAL OXIDATION AND THE EXPRESSION OF COX-1,2 IN EXPERIMENTAL GASTROPATHY. Experimental and Clinical Gastroenterology Journal. 2018;154(06):81-85
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    1. N. V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Healthcare (Moscow, Russian Federation)

    Keywords: acetaminophen, intestinal microflora, experiment, rats

    Abstract:Objective: To study the qualitative and quantitative composition of microflora in the jejunum and the cecum in acetaminophen administration. Materials and methods: The experiments were carried out on 30 rats male Wistar rats weighing 400-450 g. The influence of intragastric administration of acetaminophen (500 mg/kg) on the microflora in the jejunum and cecum has been studied. Results: It is shown that administration of acetaminophen within 21 days no changes composition of the jejunal microbiota, but leads to decrease species composition and to significant inhibition of lactobacillus and bifidobacterium in the cecum..

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      7. Parmar S.R., Vashrambhai P. H., Kalia K. Hepatoprotective activity of some plants extract against paracetamol induced hepatotoxicity in rats // J Herbal Med Toxicol. –2010. – Vol. 4, № 2.-Р.101–106.
      8. Sivkov A. V., Sinyukhin V. N., Arzumanov S. V., Stetsyuk E. A., Korobova, T. A. Uremic toxins in blood of patients with end-stage renal failure with intestinal dysbiosis // Experimental and clinical urology. – 2014. – № 2. – P. 94–97.
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    Full text is published :
    Tropskaya N. S., Vilkova I. G., Kislykova E. A., Kislicina O. S. et al. THE CHANGE OF INTESTINAL MICROFLORA IN NONSTEROIDAL ANTI-INFLAMMATORY DRUG ACETAMINOPHEN ADMINISTRATION. Experimental and Clinical Gastroenterology Journal. 2018;154(06):86-89
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    1. Moscow clinical scientific and practical center. A. S. Loginov (Moscow, Russian Federation)
    2. Moscow Research and Practical Centre for Narcology of the Department of Public Health (Moscow, Russian Federation)
    3. Federal State Budgetary Educational Establishment of Higher Education Russian State University of Physical Education, Sport, Youth and Tourism (SCOLIPE) (Moscow, Russian Federation)
    4. Federal State-Funded Educational Institution of Higher Education "Financial University under the Government of the Russian Federation" (Moscow, Russian Federation)

    Keywords: Alcohol, rat, alcohol-associated internal injuries

    Abstract:Purpose. Experimentally determine the volume and time stages of damage formation associated with the use of low-alcohol (SAN) and energy drinks (EN) in rats. Material and methods. 45 white Wistar rats were used, the experimental animals were divided into three series consisting of three groups. The first a series of age - 1.5 month; the second a series of - 12 months. The third series-24 months. In each series of 3 groups: 1-I control (intact), animals had the free access to clean water and customary food. 2nd experimental group rats with free access to water and food was added to the drinking bowl with AL “Red Bull” or SAN “Black Russian”. Autopsy after 14 and 45 days, or if necessary, when the animals died from drinking. After the autopsy, the abdominal and thoracic cavities were examined. To assess the revealed injuries, the damage index (di) was calculated, which was calculated by the number of organs with injuries and divided by the number of animals in the group. Conclusion. Experimental animal studies have established a single pathogenetic mechanism and cause-and-effect relationship between blood flow disorders associated with alcohol and multiple (polymorbidity) internal injuries. Low-alcohol drinks (cocktails) are not harmless drinks, they cause multiple toxic damage to the internal organs in the “young” rats appear damage characteristic of the “old” animals. In this case, aging is not age, but disease. Low-alcohol and energy drinks are conducive to the use of stronger drinks (“Rare” - Red bull + vodka). Decrease in the instinct of self-preservation-refusal of food and drink in combination with polymorbidity of lesions of internal organs leads to death of animals. Easy access for young people and the widespread availability of low-alcohol and energy drinks (cocktails) are a subject of discussion and attention for educators and doctors.

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    Full text is published :
    Fedotova Т.F., Mikhalev I.V., Efremov L.I., Kleschev V.N. et al. ALCOHOL ASSOCIATED INTERNAL INJURY IN RATS. Experimental and Clinical Gastroenterology Journal. 2018;154(06):90-93
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