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    1. Federal State Budget Educational Institution of Higher Education «Novosibirsk State Medical University» of the Ministry of Heal th of Russia (FSBEI HE NSMU MOH Russia) (630091, Novosibirsk, Russia)

    Keywords:Klippel- Trenaunay syndrome, rectal bleeding, angiodysplasia

    Abstract: Purpose of the study . Description of the case of the Klippel-Trenone syndrome. Materials and methods . A short review of the literature on the problem of the Klippel-Trenone syndrome and a description of the clinical observation is presented. Results . The abdominal form of the Klippel-Trenone syndrome is a rare variant of this type of pathology. This report describes the observation of a 65-year-old patient, with the abdominal form of the Klippel- Trenone syndrome, manifesting rectal bleeding Сonclusion . Thus, the study of literature and our observation shows that in the pr esence of typical manifestations of the Klippel-Trenone syndrome, bleeding from the organs of the gastrointestinal tract can have the same vascular- malformational nature.

      1. Cha, S. H. Visceral manifestations of Klippel-Trénaunay syndrome / S. H. Cha, M. A. Romeo, J. A. Neutze. // Ra- diographics. – 2005 – Vol. 25 – P. 1694–1697.
      2. Baskerville, P. A. Th e etiology of the Klippel-Trenaunay syndrome. / P. A. Baskerville, J. S. Ackroyd, N. L. Browse. // Ann Surg. . – 1985 – Vol. 202 – P. 624–627.
      3. Arguedas, M. R. Congenital vascular lesions of thega- strointestinal tract: Blue rubber bleb nevus and Klip- pel-Trenaunay syndromes / M. R. Arguedas, G. Shore, C. M. Wilcox // South Med J. – 2001 – Vol. 94 – P. 405–410.
      4. Oduber, C. E. Klippel-Trenaunay syndrome: Diagnos- tic criteria and hypothesis on etiology. / C. E. Oduber, C.M. van der Horst, R. C. Hennekam. // Ann Plast Surg. – 2008 – Vol. 60 – P. 217–223.
      5. Mussack, T. Klippel-Trenaunay syndrome with involve- ment of coecum and rectum: A rare cause of lower- gastrointestinal bleeding. / T. Mussack, J. T. Siveke, K. J. Pfeifer, C. Folwaczny. // Eur J Med Res. – 2004 – Vol. 11 – P. 515–517.
      6. Levitan, B.N., Popov E. A., Timoshenko N. V. Klippel’s syn- drome – Trenone (SCT) as a cause of recurrent gastrointesti- nal bleeding. Rossijskij zhurna l gastroe`nterologii, gepatologii, koloproktologii. Prilozhenie. 2005, vol. 15, pp. 515–517.
      7. Schmitt, B. Severe hemorrhage from intestinal heman- giomatosis in Klippel-Trenaunay syndrome: Pitfalls in diagnosis and management / B. Schmitt, H. G. Posselt, K. L. Waag, et al. // J Pediatr Gastroenterol Nut. – 1986 – Vol. 5 – P. 155–158
      8. Wang , Z . K . Klippel-Trenaunay syndrome withgastroin- testinal bleeding, splenic hemangiomas and left inferior vena cava. / Z. K. Wang, F. Y. Wang, R. M. Zhu, J. Liu. // World J Gastroenterol. – 2010 – Vol. 16 – P. 1548–1552.

    Full text is published :
    Chekanov А. M., Chekanov M. N., Osipenko M. F., Shtofi n S. G. , Shamray A. B., Blagitko E. M. Abdominal form of Klippel-Trenau nay syndrome (case report). Experimental and Clinical Gastroenterology. 2018;155(7): 155–157.
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    1. Federal State Budget Educational Institution of Higher Education «Novosibirsk State Medical University» of the Ministry of Heal th of Russia (FSBEI HE NSMU MOH Russia) (630091, Novosibirsk, Russia)
    2. Center for New Medical Technologies (Novosibirsk, Russia)

    Keywords: viral hepatitis C, antiviral therapy, resistance

    Abstract: A clinical case of a virologic breakthrough in a patient with a 1b genotype after a 12-week therapy with ombitasvir + pari- trapeprivir / ritonavir + dasabuvir, due to signifi cant mutations in the NS3, NS5a, and NS5b region of the virus is presented.

      1. EASL Recommendations on Treatment of Hepatitis C2018 // J. Hepatol, 2018, [Epub ahead of print].
      2. Messina J.P., Humphreys I., Flaxman A. et al. Global dis- tribution and prevalence of hepatitis C virus genotypes // Hepatology, 2015, Vol. 61, no. 1, pp. 77–87.
      3. Perelló C., Carrión J. A., Ruiz-Antorán B. et al. Eff ectiveness and safety of ombitasvir, paritaprevir, ritonavir ± dasabuvir ± ribavirin: an early access programme for Spanish patients with genotype 1/4 chronic hepatitis C virus infection // J. Viral Hepat, 2017, Vol. 24, no. 3, pp. 226–237.
      4. Muñoz-Gómez R., Rincón D., Ahumada A. et al. Th erapy with ombitasvir/paritaprevir/ritonavir plus dasabuvir is eff ective and safe for the treatment of genotypes 1 and 4 hepatitis C virus (HCV) infection in patients with severe renal impairment: a multicentre experience // J. Viral Hepat, 2016 [Epub ahead of print].
      5. Sarrazin C, Zeuzem S. Resistance to direct antiviral agents in patients with hepatitis C virus infection. // Gastroenterology, 2010, Vol. 138, pp. 447–462.
      6. Sarrazin C, Dvory-Sobol H, Svarovskaia ES, et al. Prev- alence of resistance-associated substitutions in HCV NS5A, NS5B, or NS3 and outcomes of treatment with ledipasvir and sofosbuvir. // Gastroenterology. 2016 [Epub ahead of print ].

    Full text is published :
    Voloshinа N. B., Voloshina I. O., Cholin S. I. Virological breakthrough after therapy with ombitasvir + paritaprevir / ritona vir + dasabuwir in a patient with the 1B genotype of viral hepatitis C. Experi mental and Clinical Gastroenterology. 2018;155(7): 158–160.
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    1. Federal State Budget Educational Institution of Higher Education «Novosibirsk State Medical University» of the Ministry of Heal th of Russia (FSBEI HE NSMU MOH Russia) (630091, Novosibirsk, Russia)

    Keywords: damage of bile duct, bowel fi stul as, reconstuctive surgery, nitinol

    Abstract: The study describes a case of a two-stage reconstructive surgical reconstruction in a patient with with damage of common bile duct and unformed bowel fi stu las.


    Full text is published :
    Shtofi n S. G., Atamanov K. V., Shtofi n G. S., Shumkov O. A., Egorov V. A. Surgical reconstruction in patient with damage of c ommon bile duct and unformed bowel fi stulas. Experimental and Clinical Gastroenterology. 2018;155(7): 161–162.
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    1. Federal State Budget Educational Institution of Higher Education «Novosibirsk State Medical University» of the Ministry of Heal th of Russia (FSBEI HE NSMU MOH Russia) (630091, Novosibirsk, Russia)

    Keywords: Infl ammatory bowel disease, ulcerative colitis, Crohn’s disease, bacterial overgrowth syndrome

    Abstract: Infl ammatory bowel diseases (IBD) — ulcerative colitis (UC) and Cr ohn’s disease (CD) are characterized by a specifi c clinic: diarrhea, the presence of blood in the stool, abdominal pain, general weakness. However, IBD can be combined with other bowel diseases, for example, with the bacterial overgrowth syndrome (BOS). BOS may not be suspected due to the similarity of symptoms with manifestations of exacerbation of CD or UC, the symptoms of BOS can be regarded only as a manifesta- tion of IBD, which leads to incorrect treatment tactics. In this article, we demonstrate the clinical case of such a combinatio n.

      1. Osipenko M. F., Valuyskih E. Y., Svetlova I. O., Kuly- gina Y. A., Skalinskaya M. I., Bikbulatova E. A., Kras- ner Y. A. Registr vospalitelnich zabolevanii kishech- nika v g.Novosibirske: itogi 2016. Sibirckii nauchnii medicinckii gurnal. 2017, t 37, No 1, S61–67.
      2. Long M,, Hutfl ess S., Kappelman M. D., et al. Challenges in Designing a National Surveillance Program for In- fl ammatory Bowel Disease in the United States. Infl amm Bowel Dis. 2014, vol 20 (2), pp. 398–415.
      3. Ye Y., Pang Z., Chen W., Ju S, et al. Th e epidemiology and risk factors of infl ammatory bowel disease. Int J Clin Exp Med. 2015, vol.8 (12), pp. 22529–22542.
      4. Simian D., Fluxá D., Flores L., et al. Infl ammatory bowel disease: A descriptive study of 716 local Chilean patients. World J Gastroenterol. 2016, June 14, vol. 22 (22), pp. 5267–5275.
      5. Maev I. V., Ivashkina I. U., Kucheryavii U. A., Oga- nesyan T. Diagnostika b lechenie sindroma izbitochnogo bakterialnogo rosta v tonkoi kishke [Diagnosis and treat- ment of excess bacterial growth syndrome in the small intestine]. Experimental and Clinical Gastroenterology Journal. 2011, no. 3, pp. 125–129.
      6. Balabantseva A. P., Kliaritskaia I. L. Sovremennie pod- chodi k diagnostike sindroma izbitochnogo bakterial- nogo rosta. . КТ, 2015, No 4, s 19–27.
      7. Fava F., Danese S. Intestinal microbiota in infl ammatory bowel disease: Friend of foe? World J Gastroenterol. 2011, 17(5), pp 557–566.
      8. Lee S. Intestinal Permeability Regulation by Tight Junc- tion: Implication on Infl ammatory Bowel Diseases. Intest Res. 2015, 13(1), pp11–18
      9. Andrei M., Gologan S., Stoicescu A., et al. Small Intestinal Bacterial Overgrowth Syndrome Prevalence in Roma- nian Patients with Infl ammatory Bowel Disease. World J Gastroenterol. 2014, 20(10), pp 2482–2491.
      10. Kulygina Y. A., Makarova Y. V., Osipenko M. F. Chastota sindroma izbitochnogo bakterialnogo rosta u bolnich rasnich gastroenterologicheskich grup. Medicina I obra- sovanie v Sibiri. 2014. No 3. s. 68–76.
      11. Klaus J, Spaniol U, Adler G, et al. Small intestinal bac- terial overgrowth mimicking acute fl are as a pitfall in patients with Crohn’s Disease. BMC G astroenterol. 2009, 9, pp 61.
      12. Sánchez-Montes C, Ortiz V, Bastida G, et al. Small intes- tinal bacterial overgrowth in inactive Crohn’s disease: infl uence of thiopurine and biological treatment. World J Gastroenterol. 2014, no. 20(38), pp. 13999–4003.
      13. Quigley EM. Bacteria: a new player in gastrointestinal motility disorders-infections, bacterial overgrowth, and probiotics. Gastroenterol. Clin. North Am. 2007, 36, pp 735–748.

    Full text is published :
    Kulygina Y. A., Osipenko M. F., Bikbulatova E. A. Bacterial overgrowth syndrome in 34-year-old patient with Crohn’s disease. Experimental and Clinical Gastroenterology. 2018;155(7): 163–165.
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