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    1. Federal State Budget Educational Institution of Higher Education «Novosibirsk State Medical University» of the Ministry of Heal th of Russia (FSBEI HE NSMU MOH Russia) (630091, Novosibirsk, Russia)

    Keywords:hyperemesis gravidarum, diagnostics, treatment

    Abstract:Hyperemesis gravidarum — one of the common diseases in during I and II trimesters of pregnancy. The review presents data concerning the prevalence, clinical manifestations, methods of diagnostic s and treatment, as prevention of hyperemesis gravidarum. The literature of 2015–2018 is analyzed.

      1. Bacak S. J., Th ornburg L. L. Liver failure in pregnancy. Crit Care Clin, 2016, vol.32, no.1, pp.61–72. doi: 10.1016/j. ccc.2015.08.005
      2. Tran T. T., Ahn J., Reau N. S. ACG clinical guideline: liver disease and pregnancy. Am J Gastroenterol, 2016, vol.111, no.2, pp.76–94. doi: 10.1038/ajg.2015.430
      3. American College of Obstetricians and Gynecologists. ACOG practice bulletin no. 189 Summary: nausea and vomiting of pregnancy. Obstet Gynecol, 2018, vol.131, no.1, pp.190–3. doi: 10.1097/AOG.0000000000002450
      4. Kontonika S. M., Grammatikopoulou M. G., Th eodor- idis X. et al. Evaluation of diet quality and hyperem- esis gravidarum in pregnant women according to in- come. Clin Nutr ESPEN, 2018, vol. 24, pp. 174–175. doi: 10.1016/j.clnesp.2018.01.015
      5. Shekhar S., Diddi G. Liver disease in pregnancy. Taiwan J Obstet Gynecol, 2015, vol. 54, no.5, pp. 475–82. doi: 10.1016/j.tjog.2015.01.004
      6. Topalahmetoğlu Y., Altay M. M., Akdağ Cırık D. Depres- sion and anxiety disorder in hyperemesis gravidarum: A prospective case-control study. Turk J Obstet Gynecol, 2017, vol. 14, no. 4, pp. 214–219. doi: 10.4274/tjod.78477
      7. Ng Q. X., Venkatanarayanan N., De Deyn MLZQ . A me- ta-analysis of the association between Helicobacter py- lori ( H. pylori ) infection and hyperemesis gravidarum. Helicobacter, 2018, vol. 23, no.1. doi: 10.1111/hel.12455
      8. Yeh C. C., Tsui K. H., Wang P. H. Hyperemesis grav- idarum. J Chin Med Assoc, 2017. doi: 10.1016/j. jcma.2017.09.001
      9. Dean C., Bannigan K., O’Hara M. et al. Recurrence rates of hyperemesis gravidarum in pregnancy: a systematic review protocol. JBI Database System Rev Implement Rep, 2017, vol. 15, no. 11, pp. 2659–2665. doi: 10.11124/ JBISRIR-2016–003271
      10. Grooten I. J., Koot M. H., van der Post J. A. et al. Early enteral tube feeding in optimizing treatment of hyperem- esis gravidarum: the Maternal and Off spring outcomes aft er Treatment of HyperEmesis by Refeeding (MOTH- ER) randomized controlled trial. Am J Clin Nutr, 2017, vol.106, no.3, pp.812–820. doi: 10.3945/ajcn.117.158931
      11. London V., Grube S., Sherer D. M., Abulafi a O. Hyper- emesis Gravidarum: A Review of Recent Literature. Pharmacology, 2017, vol.100, no.3–4, pp.161–171. doi: 10.1159/000477853
      12. Morgan S. R., Long L., Johns J. Are early pregnancy com- plications more common in women with hyperemesis gravidarum? J Obstet Gynaecol, 2017, vol.37, no.3, pp. 355–357. doi: 10.1080/01443615.2016.1256955
      13. Matthews A., Haas D. M., O’Mathuna D. Pet et al. In- terventions for nausea and vomiting in early pregnan- cy. Cochrane Database Syst Rev, 2015, vol.8, no.9. doi: 10.1002/14651858.CD007575.pub4
      14. American College of Obstetricians and Gynecologists. Practice bulletin no. 153: Nausea and vomiting of preg- nancy. Obstet Gynecol, 2015, vol. 126, no.3, pp. 12–24. doi: 10.1097/AOG.0000000000001048
      15. Mathew N. R., Menon S. G., Mathew M. Ocular mani- festations in a case of Wernicke’s encephalopathy due to hyperemesis gravidarum. Oman J Ophthalmol, 2018, vol.11. no.1, pp. 85–87. doi: 10.4103/ojo.OJO_137_2017
      16. Tan A., Lowe S., Henry A. Nausea and vomiting of preg- nancy: Eff e c t s on qu a l it y of l i fe a nd d ay-to - d ay f u nc t ion . Aust N Z J Obstet Gy naecol, 2017. doi: 10.1111/ajo.12714
      17. Kleine I., Da Silva A., Ahmed W. et al. Hospital admission for hyperemesis gravidarum in women at increased risk of spontaneous preterm birth. Birth, 2017, vol. 44, no.4, pp. 384 –389. doi: 10.1111/ bir t.12303
      18. Vikanes A., Trovik J. Adverse Maternal and Birth Out- comes in Women Hospitalised due to Hyperemesis grav- idarum. Paediatr Perinat Epidemiol, 2018, vol.32, no.1, pp.52–54. doi: 10.1111/ppe.12438
      19. Boelig R. C. Th e dilemma of hyperemesis gravidarum: more a n s wer s , a nd more que s t ion s . A m J C l i n Nut r, 2 017, vol.106, no.3, pp.711–712. doi: 10.3945/ajcn.117.164194
      20. Arshad M. F., Javed N., Bekhit M. Intractable hyperemesis gravidarum in a patient with type 1 diabetes. BMJ Case Rep, 2017. doi: 10.1136/bcr-2017–222403.

    Full text is published :
    Marinkin I. O., Sokolova T. M., Kiseleva T. V., Kuleshov V. al . Hyperemesis gravidarum. Experimental and Clinical Gastroenterology. 2018;155(7): 142–145.
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    1. Izhevsk State Medical Academy (Izhevsk, Russia)
    2. Perm State Medical University named after E. A. Wagner (PSMU) of the Ministry of Healthcare of the Russian Feaderation (Perm, R ussia)
    3. State budgetary institution of health care of the Perm region “City Clinical Polyclinic No 5” (Perm, Russia)

    Keywords:pregnancy, organic and functional dyspepsia

    Abstract:A research objective was assessment of a current and the result of pregnancy at women with various types of dispepsia. 175 pregnant women are examined: 73 — with dyspepsia during pregnancy, but without that before a gestation, 46 pregnant women — with chronic gastrointestinal diseases before pregnancy and 56 pregnant women who had no dyspepsia as pregnancies in time, and in the anamnesis. The conducted research refl ects negative impact of gastrointestinal disorders of functional and organic genesis on a current of a gestation: increase in frequency of an early gestoz, placentary insuffi ciency, infections of urinary tract, anemias, deterioration in indicators of health of newborns on a scale Apgar. Dyspepsia also lead to increase in complications of childbirth and the postnatal period — epiziotomiya, postnatal endometritis. Thus, dyspepsia during pregnancy should be considered as risk factor of the complicated course of pregnancy, childbirth and the postnatal period demanding adequate correction.

      1. Sokolova M. Yu. Ekstragenitalnaya pathology at preg- nant women. Moscow, MEDPress-inform Publ., 2011.
      2. Zhukovskaya I. G., Sandakova E. A. Condition of somatic health of patients with chronic infl ammatory diseases// PMG. 2011;28 (5): 18 –25.
      3. Zhukovskaya I. G., Shireva Yu.V., Sandakova E. A. Cause and eff ect interrelations of chronic infl ammatory diseas- es of genita ls at women w it h t he accompany ing pat holo- gy// Ural medical article.2010; 3(68):70–73.
      4. Konyshko N. A. Gastrointestinal symptoms as markers of for- mation of somatic pathology at pregnant women// Bulletin of the Smolensk medical academy. 2011, no.1, pp.139–141.
      5. ASGE Standard of Practice Committee. Guidelines for endoscopy in pregnant and lactating women / A. K. Sher- g i l l [e t a l .] // G a s t roi nte s t . E ndo s e . 2 012 . Vol . 76 (1): 18 –2 4 .
      6. Romanova V. V., Shmakov R. G. Dyskinesia of a thick gut during pregnancy// Obstetrics and gynecology. 2013, no.11, pp.83–86.
      7. Sokur T. N., Dubrovina N. V. Application of a laktuloza at treatment of locks at pregnant women and in the postnatal period //Obstetrics and gynecology. 2013, no. 8, pp.103–107.
      8. Mubarakshina O. A., Somova M. N., Mubarakshin E. A. A role of alginates in pharmacotherapy of GERD during pregnancy //Obstetrics and gynecology. 2015, no. 5, pp. 96–100.
      9. Eremina E. Yu. He a r t bu r n at pre g na nt women : s a fe t re at- ment//Doctor. 2016, no. 10, pp. 17–21.
      10. Lopatina T. V., Krasnova N. A. Th e choice of antacid-drug at pregnant women //Obstetrics and gynecology. 2011, no. 6, pp.117–119.
      11. Chukhareva N. A. Heartburn pharmacotherapy at preg- nancy: safety of use of drugs of a reserve//Obstetrics and gynecology. 2016, no. 6, pp.67–72.
      12. Savas N. Gastroitestinal endoscopy in pregnency // World Y. Gastrenterol. 2014 Vol. 20. (41):15241–52.
      13. Katz P.O., Gerson L. B., Vela M. F. Guidelines for the di- agnosis and management of gastroesophageal refl ux dis- ease // Am Y. Gastroenterol. 2013, Vol. 108, no. 3, 308–28.
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    Full text is published :
    Zhukovskaya I. G., Sandakova E. A., Khlynova O. V., Sadovniche nko E. A. Peculiarities of the current and prediction of the pr egnancy in women with diff erent types of dyspeptic disorders. Experimental and Clinical Gastroenterology. 2018;155(7): 146–150.
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    1. Public budgetary educational institution of higher education “St. Petersburg State Pediatric Medical University ” of the Minist ry of Healthcare of the Russia (St. Petersburg, Russia)
    2. St.Petersburg public budgetary Health care institution “Children's Сity Policlinic No 8” of the Ministry of Healthcare of the Ru ssia (St. Petersburg, Russia)
    3. Pirogov Russian National Research Medical University of the Mi nistry of Health, Moscow, Russian Federation (Moscow, Russia)

    Keywords:thyroid peroxidase antibodies, thyroglobulin antibodie s, thyroid status, atopy, children, gastroduodenitis

    Abstract: The aim was to investigate the thyroid status in children with chronic gastroduodenitis in combination with such atopic diseases as bronchial asthma and atopic dermatitis. Materials and мethods . 39 children of pre-pubertal age that have a morphologically confi rmed diagnosis of chronic gas- troduodenitis-CGD were examined with an ELISA. The children were divided into 2 groups: 1 — a group of 16 children with HGD only; the second is 23 children with CGD and atopy. Results . In both groups, the mean T3, T4, T4cb, TTG levels and the number of patients with normal levels of thyroid hormones in the blood serum were the same . A higher level of antibodies to thyrog lobulin was found in patients with CGD and atopy and a higher level of antibodies to thyroid peroxidase in patients with CGD only. The mechanism of the revealed diff erences requires additional study.

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    Full text is published :
    Listopadova A. P., Zemskova Е. А., Zamyatina Yu.E., Tyrtova L. V. et al. Thyroid status in children with chronic gastroduodenitis and related atopic diseases. Experimental and Clinical Gastroenterology. 2018;155(7): 151–154.
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