1. E. A. Vagner Perm State Medical University (614990, Perm, Russia)
2. Regional children’s clinical hospital (614066, Perm, Russia)

Keywords: hereditary tyrosinemia, mutation p.Gln 64 His, FAH gene, liver cirrhosis

Abstract: Hereditary tyrosinemia is a rare genetic disease, the diagnosis of which is diffi cult. The clinical case of a 5-year-old child with hereditary tyrosinemia presented, with the mutation p.Gln 64 His in the FAH gene in the homozygous state. Clinical manifestations of the disease proceeded with cirrhosis and portal hypertension, kidney pathology and deformation of the bones.

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Full text is published :
Vinokurova L. N., Shadrina V. V., Furman E. G., Cheremnyh L. I., Prozumentik V. R. Tyrosinemia type B liver and kidney have a 5-year-old child. Experimental and Clinical Gastroenterology. 2018;156(8): 140–145.
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1. E. A. Vagner Perm State Medical University (614990, Perm, Russia)

Keywords: portal hypertension, pregnancy, hypersplenism, varicose veins of the esophagus and stomach

Abstract: At present, there is a tendency to increase the number of women with portal hypertension of diff erent genesis planning pregnancy. Extrahepatic portal hypertension, in most cases associated with congenital disorders of the portal vein thrombosis or vascular portal and forming pools of portal hypertension occurs in childhood. Patients with malformations of the portal vein during pregnancy have a higher risk of complications such as hypersplenism and bleeding from varicose veins of the esophagus and stomach, which is the main cause of maternal mortality in this pathology. The article presents a clinical case of a successful outcome of pregnancy in patients with extrahepatic portal hypertension due to congenital malformation of the portal vein and its branches, korregirovat (splenorenal anastomosis, double tunneling of the right lobe of the liver Isheninu) complicated with esophageal varices 1–2 items, portal gastropathy, splenomegaly, dvuhrostkovym hypersplenism (anemia, secondary thrombocytopenia provocative hemorrhagic syndrome).

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Full text is published :
Padrul M. M., Olina A. A., Sadykova G. K., Semyagina L. M., Turova E. V., Chirinkina E. V., Zaplatina V. S., Meteleva T. A., Sadykova D. K. The pregnancy in a patient with extrahepatic portal hypertension. Experimental and Clinical Gastroenterology. 2018;156(8): 146–151.
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1. Perm Regional Clinical Hospital (Perm, Russia)
2. E. A. Vagner Perm State Medical University (614990, Perm, Russia)

Keywords: Pregnancy, cirrhosis, portal hypertension, hypersplenism, delivery

Abstract: There are cases of diff erent outcomes of a pregnancy in women with a cirrhosis of a virus etiology complicated by portal hypertension presented in the article. An existence of the cirrhosis complicated by the accruing portal hypertension and a hypersplenism (thrombocytopenia) which led to formation and a rupture of a hematoma of a spleen are pregnancy failure factors. An existence only of a portal hypertension without hypersplenism at an early delivery gives chance of the successful outcome for mother and a fetus.

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  3. Shekhtman M. M. Khronicheskiy gepatit i tsirroz pecheni u beremennykh [Chronic hepatitis and cirrhosis in pregnant women]. Ginekologiya – [Gynecology], 2004, no 03, pp. 141–144.
  4. Borisov A. E., Kashchenko V. A. Tsirroz pecheni i portal’naya gipertenziya [Cirrhosis and portal hypertension]. SPb, Sintez Buk, 2009, 154. p.

Full text is published :
Padrul M. M., Semyagina L. M., Sadykova G. K., Turova E. V., Semyagin I. A. Outcomes of a pregnancy at the cirrhosis of a virus etiology complicated by portal hypertension. Experimental and Clinical Gastroenterology. 2018;156(8): 152–156.
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1. E. A. Vagner Perm State Medical University (614990, Perm, Russia)
2. Tumen state medical University (Tumen, Russia)
3. Federal State Bugetary Scientifi c Institution “The Research Institute of Obstetrics, Gynecology and Reproductology named after D. O. Ott”

Keywords: liver hemangioma, estrogen, menopausal hormone therapy, premature menopause

Abstract: Hemangioma of the liver is one of the most common benign liver tumors. The tumor has a mesenchymal origin and is a conglomerate of blood vessels. It is more common in women 30–60 years old. Risk factors also include the use of a number of medications (including estrogens) and high parity. This article describes a clinical case of a patient with liver hemangioma and prolonged menopausal hormone therapy at premature menopause.

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  3. Xacko V. V., Kuz’menko A.E., Vojtjuk V. N., Matvienko V. A. ets. Diagnosis and treatment of hemangiomas of the liver. Ukrainian Journal of Surgeryю 2014; 3–4(26– 27):131–135.
  4. Panay N., hamoda H., Arya R., Savvas M. Th e 2013 British Menopause Society, Women Health Concern recommendation on hormone replacement therapy//Menopause Int. 2013. – 19(2). – С. 59–68.

Full text is published :
Olina A. A., Meteleva T. A.1, Sadykova G. K., Shevlyukova T. P. Hemangioma liver and premature menopause. Experimental and Clinical Gastroenterology. 2018;156(8): 157–159.
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1. E. A. Vagner Perm State Medical University (614990, Perm, Russia)

Keywords: toxocarosis, ferret, newborn

Abstract: The paper presents clinical observation of acquired toxocariasis in an infant in the period of newborns. Infection occurred from 5 to 22 days of life. The source of the invasion was a ferret, a female at the age of 2 years. It lived in the apartment as the pet. From the 23rd day of life the clinic developed in the form of 3 syndromes: dyspeptic, intoxication and catarrhal. In the blood test in 27 days of life, eosinophilia 25% (abs. 4250 cells), leukocytosis 17.0 x109/L. At the age of 1 month 20 days eosinophilia was 41%. The titer of antibodies to toxocarosis in the infant was 1:1600 in three analyzes. At the mother of the infant, the result of ELISA was negative twice. Therefore, we made the conclusion about the acquired nature of the invasion. At the time of diagnosis of toxocarosis at the age of 1.5 months, we decided to refrain from specifi c antinematodic therapy. This therapy can give the high risk of fulminant form of toxic hepatitis in infants. At the age of 4 months, the result of the control ELISA was negative. We can suppose self-healing, the natural sanitation of the child’s body from helminthic invasion. In catamnesis in 2 years 4 months was recommended to repeat ELISA on toxocarosis.

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  2. Yuhimenko G. G., Maydannik V. G. Toksokaroz u detey [Toxocariasis in children]. Mezhdunarodnyy zhurnal pediatrii, akusherstva i ginekologii – [International journal of Pediatrics, obstetrics and gynecology], 2012, vol. 2, no. 1, pp. 124–134.
  3. Denisov M. Yu. Parazitarnye bolezni organov pishchevareniya [Parasitic diseases of the digestive system]. Bolezni organov pishchevareniya u detey i podrostkov [Digestive diseases in children and adolescents]. Rostov-na-Donu, Feniks Publ., 2005. 607 p.
  4. Nazarenko S. I., Mozgova L. A., Nazarenko L. V. Vyyavlennyy sluchay vrozhdennogo toksokaroza [Revealed case of congenital toxocarosis]. Informacionnyy byulleten Novosti «Vektor-Best» [Newsletter news “Vector-best»], 2000, vol. 16, no. 2, pp. 5–6.
  5. Zaharchuk A. I. Toksokaroz u mladencev (Kliniko-laboratornoe i serologicheskoe obsledovanie) [Toxocarosis in infants (Clinical, laboratory and serological examination)]. Molodoy uchenyy – [Young scientist], 2014, no. 2, pp. 329–337.
  6. Lebedeva O. V. Epidemiologiya toksokaroza v Sankt-Peterburge. Diss. kand. med. nauk [Epidemiology of toxocarosis in St. Petersburg. Cand. med. sci. diss.]. S.-Ptb., 2006, 24 p.
  7. Botkina A. S., Dubrovskaya M. I. Larvalnye gelmintozy. Toksokaroz v pediatricheskoy praktike [Larva migrans. Toxocariasis in a pediatric practice]. Lechashchiy vrach – [Treating physician], 2016, no. 6, pp. 29–33.
  8. Kornienko E. A., Shabalov N. P., Erman L. V. Zabolevaniya organov pishchevareniya [Diseases of the digestive system]. «Detskie bolezni» pod red. N. P. Shabalov [Children’s diseases ed. N. Shabalov], 2008, vol. 1, pp. 638–844.

Full text is published :
: Vshivtceva N. B., Repetckaya M. N., Toropova E. A. Acquired toxocariasis in a newborn. Experimental and Clinical Gastroenterology. 2018;156(8): 160–163.
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