1. E. A. Vagner Perm State Medical University (614990, Perm, Russia)

Keywords: narcotic intoxication, hepatitis, fi brosis

Abstract: World statistics shows a widespread and steady increase in the number of patients with addiction among whom, according to many domestic and foreign authors, an increasing proportion falls on patients with diseases caused by the use of drugs from the opium group. The article presents an overview of scientifi c publications devoted to the peculiarities of reactive liver changes in people who use acetylated opiates — heroin. The features of the course, progression of the pathological process during narcotic intoxication, as well as mixed variants in combination with viral hepatitis are considered.

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Full text is published :
Shchekotova A. P., Nevzorova M. S., Bulatova I. A., Chepkasova N. I., Botalov N. S. Features of liver disease in narcotic intoxication. Experimental and Clinical Gastroenterology. 2018;156(8): 88–93.
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1. E. A. Vagner Perm State Medical University (614990, Perm, Russia)

Keywords: morphology, nonparasitic liver cysts, dysembryogenesis, liver

Abstract: Literature review refl ects modern view on morphogenesis of nonparasitic liver cysts. Morphological characteristic and embryogenesis varies with diff erent variants of dysontogenetic cysts are presented.

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Full text is published :
Freynd G. G., Zhivaeva E. V. Morphogenetic variants of nonparasitic liver cysts. Experimental and Clinical Gastroenterology. 2018;156(8): 94–98.DOI: 10.31146/1682-8658-ecg-156-8-94-98
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1. E. A. Vagner Perm State Medical University (614990, Perm, Russia)
2. Perm Krai Clinical Hospital

Keywords: liver resection, bile leakage, biliary complications

Abstract: The aim of the literature review was to present the modern statement of frequency, classifi cations, management and risk factors of bile leakage after hepatectomy. Objectives. Our retrospective study includes 363 consecutive patients that underwent liver resection. Results. The incidence of bile leakage was found to be 7,7%: bilomas appeared in 5,2% and external bile fi stulas — in 2,5%. Ten from 19 bilomas were treated by percutaneous puncture under ultrasound control. Procedure was repeated from one to four times. Nine patients were treated with percutaneous drainage. After that 8 external bile leakages were stopped during 4–12 weeks. One patient had the dilatation of common bile duct. She underwent endoscopic papillotomy. Among nine patients with external bile leakage six were treated conservatively. Central type leakage (2) that was in communication with bile duct of the fourth segment was treated with endoscopic retrograde 7 and 10 Fr stent with 9 and 11 cm length. Stent was placed to left and common bile ducts. Bile leakage stopped during 2–3 days. One patient was reoperated. Multivariate analysis indentifi ed only one independent factor that was signifi cantly correlated with the occurrence of bile leakage: right hepatectomy. More meticulous management is needed to prevent bile leakage in high-risk patients. Conclusion. Endoscopic retrograde stent appeared quick and successful in cases of central type leakage that was in communication with segmental bile duct.

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Kotelnikova L. P., Grebenkina S. V., Trushnikov D. V. Bile leakage after liver resection. Experimental and Clinical Gastroenterology. 2018;156(8): 99–106.
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1. Federal public budgetary educational institution of higher education “Omsk State Medical University” of the Ministry of Healthcare of the Russia (Omsk, Russia)
2. Omsk State Agrarian University P. A. Stolypin (Omsk, Russia)

Keywords: liver transplantation, risk factors, diabetes mellitus

Abstract: There is a higher prevalence of performed transplants of solid organs in Russia. Liver transplantation (LT) is the most eff ective way to treat liver diseases at advanced stages, and for many patients –the only eff ective one. Marked improvement in the surgery leads to the advances in LT techniques and the increase of overall number of LTs performed. However the number of recipients with metabolic disorders requiring medical interventions increases as well. LT can be accompanied by several complications. The most common one is diabetes mellitus (DM). New onset DM after LT increases the risk of transplant rejection, infection, adverse cardiovascular outcomes and reduces the survival of patients. An early diagnostics of carbohydrate metabolism disturbances in patients who underwent LT might be achieved with rigorous identifi cation of the risk factors associated with DM development after and proper screening performed before the intervention. Beyond these, in a particular group of solid organs recipients a rational administration of drug therapy for DM, which is based on evidence of treatment outcome, safety and drug interactions with immunosuppressive therapy, should improve the number of adverse outcomes and contribute to eff ective blood glucose control in a postoperative period after LT.

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Druk I. V., Drokina O. V., Lyalyukova E. A., Ryapolova E. A., Vysokogorskiy V. E., Moliboga E. A. New-onset diabetes after liver transplantation: epidemiology, risk factors, medical therapy at the outpatient stage. Experimental and Clinical Gastroenterology. 2018;156(8): 107–115.DOI: 10.31146/1682-8658-ecg-156-8-107-115
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