1. FRC CSC RAS, Institute of Pharmacoinformatics, 119333, Moscow, Vavilova, 42, Russia
2. Big Data Storage and Analysis Center (CCHD), Moscow State University, Moscow, Russia
3. Federal State Budgetary Educational Institution of Further Professional Education “Russian Medical Academy of Continuous Professional Education” of the Ministry of Healthcare of the Russian Federation, Moscow, Russia

Keywords: prebiotics, lactitol, microbiome, human microbiota, area under the growth curve, chemoinformatics, data mining, system biology

Abstract: Recently, more attention has been paid to studying the relationship between the state of the intestinal microbiome and the state of both the intestine itself and other human organs. In this connection, interest arises in studying the effect on the microbiome of both well-known molecules with a prebiotic effect and the lactose derivative, lactitol, which is relatively recently used in clinical practice. Prebiotic molecules differ significantly in their effects on the microbiome of the human intestine. A systematic study of this issue has not been conducted previously. This work presents the results of a comparative chemomicrobiome analysis of lactitol, lactulose, sorbitol, xylitol and fructose, carried out using modern technologies for the analysis of "big data". For each of the molecules studied, estimates of the area under the growth curve were obtained for a representative sample of human microbiota, including 36 commensal bacteria, including bifidobacteria and lactobacilli. It is shown that lactitol stimulates the growth of the population of bifidobacteria and beneficial eubacteria, as well as microorganisms producing butyric acid, to a greater extent than comparison molecules, and thus, to a greater extent than comparison molecules, it improves the condition of the colon.

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Full text is published :
Torshin I. Yu., Gromova O. A., Zakcharova I. N., Maximov V. A. Hemomikrobiomny lactitol analysis. Experimental and Clinical Gastroenterology. 2019;164(4): 111–121. (In Russ.) DOI: 10.31146/1682-8658-ecg-164-4-111-121
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