1. State Scientifi c Center of Coloproctology, 123423, Moscow, Russia, st. Salam Adil, 2

Keywords: Antibiotic-associated diarrhea, Clostridium diffi cile, clostridial colitis

Abstract:Aim. To assess etiologic factor of Clostridium genus associated infection and its infl uence on the disease clinical course. Materials and methods. 549 in-hospital patients participated in the study. We evaluated clinical and biochemical parameters of blood, stool frequency or stoma function intensity, feces volume per day and length of in-hospital stay. We performed stool sampling three times: during 48 hours after admission, in case of diarrhea and prior discharge. We evaluated glutamate-dehydrogenase (GDH) and Clostridium diffi cile toxins A and B by means of immunological assays. All samples underwent cultivation in anaerobic conditions. Results. Analysis of clostridial infection ethiologic factor has revealed 38 (17,9%) cases of clostridial diarrhea associated with another Clostridium species. We discovered Clostridium perfringens in 32 (84%) cases, Clostidium novyi in 5 (13%) cases and Clostidium hathewayi in 1 (3%) patient. Diarrhea severity, clinical and laboratory infl ammation markers did not diff er signifi cantly depending on the isolated etiological agent of clostridial infection and its titer. Clostridial infection signifi cantly increased in-hospital post-surgery length of stay by 4 days (p < 0,01). Conclusions. Symptoms C. diffi cile-associated infection could occur not only in case of persisting C. diffi cile but also in cases of other Clostridium species. Clinical manifestation of C. diffi cile-associated infection increase in-hospital stay.

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Full text is published :
Achkasov S. I., Sukhina M. A., Sushkov O. I., Frolov S. A., Kashnikov V. N., Safi n A. L., Egorkin M. A. Clinical aspects of nosocomial diarrhea associated with Clostridium (Clostridioides) diffi cile in coloproctologic patients. Experimental and Clinical Gastroenterology. 2018;160(12): 58–63. (In Russ.) DOI: 10.31146/1682-8658-ecg-160-12-58-63
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