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ОБЗОР

    1. Федеральное государственное бюджетное научное учреждение «Федеральный исследовательский центр “Красноярский научный центр Сибирского отделения Российской академии наук”» (ФИЦ КНЦ СО РАН), обособленное подразделение «Научно-исследовательский институт медицинских проблем Севера» (НИИ МПС) (Красноярск, Россия)

    Ключевые слова: микробиом,микрофлора,желудок,H. pylori,патология

    Резюме: Публикация в 1984 г. в журнале Lancet австралийских авторов R. Warren и B. Marshall об обнаружении Helicobacter pylori стала первым этапом революционных изменений взглядов на развитие патологии желудка. Начало 21 века ознаменовалось доказательством существования в желудке большого количества других микроорганизмов. Второй этап революции верифицирован Киотским консенсусом по гастриту и европейским консенсусом Маастрихт 5, подтвердившими возможность жизнедеятельности и ассоциации с патологией желудка различных бактерий, вирусов и грибов.

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      3. Fraher M.H., O’Toole P.W., Quigley E.M. Techniques used to characterize the gut microbiota: a guide for the clinician. Nature Reviews Gastroenterology & Hepatology. 2012;9(6):312–322.
      4. Bik E.M., Eckburg P.B., Gill S.R., Nelson K.E., Purdom E.A., Francois F., Perez-Perez G., Blaser M.J., Relman D.A. Molecular analysis of the bacterial microbiota in the human stomach. Proc. Natl. Acad. Sci. USA. 2006;103(3):732–737.
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      6. Engstrand L., Lindberg M. Helicobacter pylori and the gastric microbiota. Best Practice & Research Clinical Gastroenterology. 2013;27(1):39-45.
      7. Delgado S., Cabrera-Rubio R., Mira A., Suárez A., Mayo B. Microbiological survey of the human gastric ecosystem using culturing and pyrosequencing methods. Microbial Ecology. 2013;65(3):763–772.
      8. Cao L., Yu J. Effect of Helicobacter pylori Infection on the Composition of Gastric Microbiota in the Development of Gastric Cancer. Gastrointestinal Tumors. 2015;2(1):14–25.
      9. Tan M.P., Kaparakis M., Galic M., Pedersen J., Pearse M., Wijburg O.L.C., Janssen P.H., Strugnell R.A. Chronic Helicobacter pylori infection does not significantly alter the microbiota of the murine stomach. Appl. Environ. Microbiol. 2007;73(3):1010–1013.
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      18. Dicksved J., Lindberg M., Rosenquist M., Enroth H., Jansson J.K., Engstrand L. Molecular characterization of the stomach microbiota in patients with gastric cancer and in controls. Journal of Medical Microbiology 2009. 58(4):509–516.
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    Для цитирования :
    Цуканов В.В., Каспаров Е.В., Васютин А.В., Тонких Ю.Л. РОЛЬ МИКРОБИОТЫ В РАЗВИТИИ ПАТОЛОГИИ ЖЕЛУДКА. Экспериментальная и клиническая гастроэнтерология. 2017;148(12):47-50
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    1. ФГБОУ ВО Дальневосточный государственный медицинский университет Минздрава Российской Федерации (Владивосток, Россия)

    Резюме: Проблема экстрагастродуоденальных проявлений инфекции Helicobacter pylori изучается более 20 лет. Значение Helicobacter pylori в развитии идиопатической тромбоцитопенической пурпуры, железодефицитной и B 12-дефицитной анемии, атеросклероза, ожирения, бронхиальной астмы, болезни Альцгеймера, болезни Паркинсона нашло отражение в V Маастрихтском соглашении. В обзоре приведены полученные в последние годы данные о взаимосвязи хеликобактерной инфекции с развитием сердечно-сосудистых, неврологических, гематологических, дерматологических заболеваний, а также с развитием сахарного диабета и метаболического синдрома.

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    Для цитирования :
    Алексеенко С.А., Колтунов А.С., Колтунов С.С. ЭКСТРАГАСТРОДУОДЕНАЛЬНЫЕ ПРОЯВЛЕНИЯ ХЕЛИКОБАКТЕРНОЙ ИНФЕКЦИИ. Экспериментальная и клиническая гастроэнтерология. 2017;148(12):51-55
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    1. Кубанский государственный медицинский университет (Краснодар, Россия)
    2. Краевая клиническая больница № 2 (Краснодар, Россия)

    Ключевые слова: эозинофильный эзофагит,диагностика

    Резюме: Эозинофильный эзофагит (ЭоЭ) - редко диагностируемое заболевание, протекающее с явлениями дисфагии, основной отличительной чертой которого является эозинофильная инфильтрация слизистой оболочки пищевода. Представлен клинический случай, демонстрирующий трудности дифференциальной диагностики ЭоЭ и гастроэзофагеальной рефлюксной болезни (ГЭРБ). ЭоЭ - болезнь, сходная по клинике с ГЭРБ, но отличная по этиопатогенезу, требующая принципиально иного подхода к лечению. Несмотря на четкие дифференциально-диагностические критерии, необходимо помнить, что для исключения ГЭРБ клиницист должен анализировать всю совокупностью клинических и гистологических данных, что позволит сделать правильное заключение и выбрать адекватную лечебную тактику.

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      2. Gonsalves N., Policarpio–Nicolas M., Zhang Q., Rao M.S., Hirano I. Histopathologic variability and endoscopic correlates in adults with eosinophilic esophagitis. Gastrointestinal Endoscopy. 2006;64(3):313-322.
      3. Dellon E.S., Gibbs W.B., Fritchie K.J., Rubinas T.C., Wilson L.A., Woosley J.T., Shaheen N.J. Clinical, endoscopic, and histologic findings distinguish eosinophilic esophagitis from gastroesophageal reflux disease. Clinical Gastroenterology and Hepatology. 2009;7(12):1305-1313.
      4. Liacouras C., Furuta G., Hirano I., Atkins D., Attwood S.E., Bonis P.A., Burks A.W., Chehade M., Collins M.H., Dellon E.S., Dohil R., Falk G.W., Gonsalves N., Gupta S.K., Katzka D.A., Lucendo A.J., Markowitz J.E., Noel R.J., Odze R.D., Putnam P.E., Richter J.E., Romero Y., Ruchelli E., Sampson H.A., Schoepfer A., Shaheen N.J., Sicherer S.H., Spechler S., Spergel J.M., Straumann A., Wershil B.K., Rothenberg M.E., Aceves S.S. Eosinophilic esophagitis: updated consensus recommendations for children and adults. The Journal of Allergy and Clinical Immunology. 2011;128(1):3-20.
      5. Ivashkin V.T., Baranskaya E.K., Kaibysheva V.O. et al. Klinicheskie rekomendatsii po diagnostike i lecheniyu eozinofil'nogo ezofagita. Moscow, 2013. 38 p.
      6. Langdon D. E. Congenital esophageal stenosis, corrugated ringed esophagus, and eosinophilic esophagitis. Am. J. Gastroenterol. 2000;95:2123-2124.
      7. Lim J., Gupta S., Fitzgerald J. et al. White specks in esophageal mucosa: a true endoscopic manifestation of severe eosinophilic esophagitis in children. J. Pediatr. Gastroenterol. Nutr. 2001;33:411.
      8. Krarup A., Villadsen G., Mejlgaard E., Olesen S.S., Drewes A.M.,Funch-Jensen. Acid hypersensitivity in patients with eosinophilic esophagitis. Scandinavian Journal of Gastroenterology. 2010;45(3):273-281.
      9. Markowitz J., Liacouras C. Eosinophilic esophagitis. Gastroenterology Clinics of North America. 2003;32(3):949-966.
      10. Foroutan M., Norouzi A., Molaei M., Mirbagheri S.A., Irvani S., Sadeghi A., Derakhshan F., Tavassoli S., Besharat S., Zali M. Eosinophilic esophagitis in patients with refractory gastroesophageal reflux disease. Digestive Diseases and Science. 2010;55(1):28-31.
      11. Landres R., Kuster G., Strum W. Eosinophilic esophagitis in a patient with vigorous achalasia. Gastroenterology. 1978;74:1298-301.
      12. Prasad G.A., Alexander J.A., Schleck C.D., Zinsmeister A.R., Smyrk T.C., Elias R.M., Locke G.R., Talley N.J. Epidemiology of eosinophilic esophagitis over three decades in Olmsted county, Minnesota. Clin. Gastroenterol. Hepatol. 2009;7(10):1055-1116.
      13. Straumann A., Spichtin H., Bernoulli R. Loosli J., Vögtlin J. Idiopathic eosinophilic esophagitis: a frequently overlooked disease with typical clinical aspects and discrete endoscopic findings (in German). Schweiz. Med. Wochenschr. 1994;Vol.124:1419-1429.
      14. Ahmad M., Soetikno R., Ahmed A. The differential diagnosis of eosinophilic esophagitis. Journal of Clinical Gastroenterology. 2000;30(3):242-244.
      15. Bohm M., Richter J., Kelsen S., Thomas R. Esophageal dilation: simple and effective treatment for adults with eosinophilic esophagitis and esophageal rings and narrowing. Diseses of the Esophagus. 2010;23(5):377-385.
      16. Furuta G. T. Eosinophilic esophagitis: Update on clinicopathological manifestations and pathophysiology. Curr. Opin. Gastroenterol. 2011;27(4):383-388.


    Для цитирования:
    Серикова С.Н., Корочанская Н.В. ТРУДНОСТИ ДИФФЕРЕНЦИАЛЬНОЙ ДИАГНОСТИКИ ЭОЗИНОФИЛЬНОГО ЭЗОФАГИТА И ГАСТРОЭЗОФАГЕАЛЬНОЙ РЕФЛЮКСНОЙ БОЛЕЗНИ. Экспериментальная и клиническая гастроэнтерологияl. 2017;148(12):56-59
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